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Blakely, Randy D.
Allan D. Bass Professor of Pharmacology and Psychiatry
Director, Silvio O. Conte Center for Neuroscience Research

Selected Publications

Biotin tethered homotryptamine derivatives: High affinity probes of the human serotonin transporter (hSERT). Tomlinson, ID; Iwamoto, H; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 1678-1682 , (2011)

Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans. Kohli, U; Hahn, MK; English, BA; Sofowora, GG; Muszkat, M; Li, C; Blakely, RD; Stein, CM; Kurnik, D, PHARMACOGENETICS AND GENOMICS, 21, 171-178 , (2011)

Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Thompson, BJ; Jessen, T; Henry, LK; Field, JR; Gamble, KL; Gresch, PJ; Carneiro, AM; Horton, RE; Chisnell, PJ; Belova, Y; McMahon, DG; Daws, LC; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 3785-3790 , (2011)

Antidepressant Action: From Molecule to Mouse to Man. Blakely, R, BIOLOGICAL PSYCHIATRY, 67, 1 , (2010)

Dependence of Serotonergic and Other Nonadrenergic Enteric Neurons on Norepinephrine Transporter Expression. Li, ZS; Caron, MG; Blakely, RD; Margolis, KG; Gershon, MD, JOURNAL OF NEUROSCIENCE, 30, 16730-16740 , (2010)

Dysregulation of Dopamine Transporters via Dopamine D-2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder. Bowton, E; Saunders, C; Erreger, K; Sakrikar, D; Matthies, HJ; Sen, N; Jessen, T; Colbran, RJ; Caron, MG; Javitch, JA; Blakely, RD; Galli, A, JOURNAL OF NEUROSCIENCE, 30, 6048-6057 , (2010)

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters. Zhu, CB; Lindler, KM; Owens, AW; Daws, LC; Blakely, RD; Hewlett, WA, NEUROPSYCHOPHARMACOLOGY, 35, 2510-2520 , (2010)

Monoamine Oxidase A-Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload. Kaludercic, N; Takimoto, E; Nagayama, T; Feng, N; Lai, EW; Bedja, D; Chen, K; Gabrielson, KL; Blakely, RD; Shih, JC; Pacak, K; Kass, DA; Di Lisa, F; Paolocci, N, CIRCULATION RESEARCH, 106, 193-U401 , (2010)

MOTOR NEURON-SPECIFIC OVEREXPRESSION OF THE PRESYNAPTIC CHOLINE TRANSPORTER IMPACT ON MOTOR ENDURANCE AND EVOKED MUSCLE ACTIVITY. Lund, D; Ruggiero, AM; Ferguson, SM; Wright, J; English, BA; Reisz, PA; Whitaker, SM; Peltier, AC; Blakely, RD, NEUROSCIENCE, 171, 1041-1053 , (2010)

Rab11 Supports Amphetamine-Stimulated Norepinephrine Transporter Trafficking. Matthies, HJG; Moore, JL; Saunders, C; Matthies, DS; Lapierre, LA; Goldenring, JR; Blakely, RD; Galli, A, JOURNAL OF NEUROSCIENCE, 30, 7863-7877 , (2010)

Transmembrane Domain 6 of the Human Serotonin Transporter Contributes to an Aqueously Accessible Binding Pocket for Serotonin and the Psychostimulant 3,4-Methylene Dioxymethamphetamine. Field, JR; Henry, LK; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 11270-11280 , (2010)

Ultrastructural Localization of High-Affinity Choline Transporter in the Rat Anteroventral Thalamus and Ventral Tegmental Area: Differences in Axon Morphology and Transporter Distribution. Holmstrand, EC; Asafu-Adjei, J; Sampson, AR; Blakely, RD; Sesack, SR, JOURNAL OF COMPARATIVE NEUROLOGY, 518, 1908-1924 , (2010)

A MODEL OF COGNITIVE DYSFUNCTION: CONSTRAINED DEMANDS ON CHOLINERGIC TRANSMISSION AND ATTENTIONAL CAPACITIES IN CHT+/- MICE. Parikh, V; Young, D; Cheema, A; Blakely, RD; Sarter, M, JOURNAL OF NEUROCHEMISTRY, 108, 71-72 , (2009)

Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. English, BA; Hahn, MK; Gizer, IR; Mazei-Robison, M; Steele, A; Kurnik, DM; Stein, MA; Waldman, ID; Blakely, RD, JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 1, 252-263 , (2009)

Enhanced activity of human serotonin transporter variants associated with autism. Prasad, HC; Steiner, JA; Sutcliffe, JS; Blakely, RD, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 364, 163-173 , (2009)

Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Carneiro, AMD; Airey, DC; Thompson, B; Zhu, CB; Lu, L; Chesler, EJ; Erikson, KM; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 2047-2052 , (2009)

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Veenstra-VanderWeele, J; Jessen, TN; Thompson, BJ; Carter, M; Prasad, HC; Steiner, JA; Sutcliffe, JS; Blakely, RD, JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 1, 158-171 , (2009)

Monoamine Oxidase A Promoter Gene Associated With Problem Behavior in Adults With Intellectual/Developmental Disabilities. May, ME; Srour, A; Hedges, LK; Lightfoot, DA; Phillips, JA; Blakely, RD; Kennedy, CH, AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES, 114, 269-273 , (2009)

NOREPINEPHRINE TRANSPORTER POLYMORPHISMS AFFECT BLOOD PRESSURE RESPONSE TO EXERCISE. Kohli, U; Hahn, MK; English, BA; Muszkat, M; Sofowora, GG; Blakely, RD; Stein, CM; Kurnik, D, CLINICAL PHARMACOLOGY & THERAPEUTICS, 85, S36-S37 , (2009)

NOREPINEPHRINE TRANSPORTER POLYMORPHISMS AFFECT BLOOD PRESSURE RESPONSE TO EXERCISE.. Kohli, U; Hahn, MK; English, BA; Muszkat, M; Sofowora, GG; Blakely, RD; Stein, CM; Kurnik, D, CLINICAL PHARMACOLOGY & THERAPEUTICS, 85, S2-S2 , (2009)

Psychiatric profile and attention deficits in postural tachycardia syndrome. Raj, V; Haman, KL; Raj, SR; Byrne, D; Blakely, RD; Biaggioni, I; Robertson, D; Shelton, RC, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80, 339-344 , (2009)

Serotonin Rising. Anderson, GM; Cook, EH; Blakely, RD, NEW ENGLAND JOURNAL OF MEDICINE, 360, 2580-2580 , (2009)

Serotonin Transporter Expression Levels Differentially Regulate P-Selectin and Glycoprotein GpIIbIIIa. Carneiro, AM; Holinstat, M; Blakely, RD; Hamm, H, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29, E50-E50 , (2009)

Structural determinants of species-selective substrate recognition in human and Drosaphila serotonin transporters revealed through computational docking studies. Kaufmann, KW; Dawson, ES; Henry, LK; Field, JR; Blakely, RD; Meiler, J, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 74, 630-642 , (2009)

Subcellular localization of the antidepressant-sensitive norepinephrine transporter. Matthies, HJG; Han, Q; Shields, A; Wright, J; Moore, JL; Winder, DG; Galli, A; Blakely, RD, BMC NEUROSCIENCE, 10, 65 , (2009)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice. Misawa, H; Fujigaya, H; Nishimura, T; Moriwaki, Y; Okuda, T; Kawashima, K; Nakata, K; Ruggiero, AM; Blakely, RD; Nakatsu, F; Ohno, H, EUROPEAN JOURNAL OF NEUROSCIENCE, 27, 3109-3117 , (2008)

Anomalous dopamine release associated with a human dopamine transporter coding variant. Mazei-Robison, MS; Bowton, E; Holy, M; Schmudermaier, M; Freissmuth, M; Sitte, HH; Galli, A; Blakely, RD, JOURNAL OF NEUROSCIENCE, 28, 7040-7046 , (2008)

Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Hoard, JL; Hoover, DB; Mabe, AM; Blakely, RD; Feng, N; Paolocci, N, NEUROSCIENCE, 156, 129-142 , (2008)

Distinctions between dopamine transporter antagonists could be just around the bend. Henry, LK; Blakely, RD, MOLECULAR PHARMACOLOGY, 73, 616-618 , (2008)

Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Carvelli, L; Blakely, RD; DeFelice, LJ, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 14192-14197 , (2008)

Functional gene variation in the human norepinephrine transporter - Association with attention deficit hyperactivity disorder. Kim, CH; Waldman, ID; Blakely, RD; Kim, KS, MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION, 1129, 256-260 , (2008)

Going with the flow: Trafficking-dependent and -independent regulation of serotonin transport. Steiner, JA; Carneiro, AMD; Blakely, RD, TRAFFIC, 9, 1393-1402 , (2008)

Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism. Zhao, JL; Matthies, DS; Botzolakis, EJ; Macdonald, RL; Blakely, RD; Hedera, P, JOURNAL OF NEUROSCIENCE, 28, 13938-13951 , (2008)

Interactions between integrin alpha IIb beta 3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro, AMD; Cook, EH; Murphy, DL; Blakely, RD, JOURNAL OF CLINICAL INVESTIGATION, 118, 1544-1552 , (2008)

Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Hahn, MK; Blackford, JU; Haman, K; Mazei-Robison, M; English, BA; Prasad, HC; Steele, A; Hazelwood, L; Fentress, HM; Myers, R; Blakely, RD; Sanders-Bush, E; Shelton, R, GENES BRAIN AND BEHAVIOR, 7, 487-495 , (2008)

Peripheral cytokine-inducers, LPS and poly I : C, upregulate CNS serotonin transporter (SERT) activity and induce depression-like Behavior in the mouse via a p38 mitogen-activated protein kinase (p38 MAPK) - Dependent mechanism. Zhu, CB; Blakely, RD; Hewlett, WA, BIOLOGICAL PSYCHIATRY, 63, 153 , (2008)

Quantum dot ex vivo labeling of neuromuscular synapses. Orndorff, RL; Warnement, MR; Mason, JN; Blakely, RD; Rosenthal, SJ, NANO LETTERS, 8, 780-785 , (2008)

Targetting the Human Serotoin Tranporter (hSERT) with Quantum Dots. Tomlinson, ID; Chang, J; Iwamoto, H; DeFelice, LJ; Blakely, RD; Rosenthal, SJ, PROCEEDINGS - SPIE, 6866, 6866-30 , (2008)

All aglow about presynaptic receptor regulation of neurotransmitter transporters. Blakely, RD; DeFelice, LJ, MOLECULAR PHARMACOLOGY, 71, 1206-1208 , (2007)

Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Dipace, C; Sung, U; Binda, F; Blakely, RD; Galli, A, MOLECULAR PHARMACOLOGY, 71, 230-239 , (2007)

Bound to be different: Neurotransmitter transporters meet their bacterial cousins. Henry, LK; Meiler, J; Blakely, RD, MOLECULAR INTERVENTIONS, 7, 306-309 , (2007)

Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A. Sung, U; Blakely, RD, MOLECULAR AND CELLULAR NEUROSCIENCE, 34, 251-260 , (2007)

Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice. Bazalakova, MH; Wright, J; Schneble, EJ; McDonald, MP; Heilman, CJ; Levey, AI; Blakely, RD, GENES BRAIN AND BEHAVIOR, 6, 411-424 , (2007)

Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. Mason, JN; Deecher, DC; Richmond, RL; Stack, G; Mahaney, PE; Trybulski, E; Winneker, RC; Blakely, RD, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 323, 720-729 , (2007)

Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Williams, J; Owens, WA; Turner, GH; Saunders, C; Dipace, C; Blakely, RD; France, CP; Gore, JC; Daws, LC; Avison, ML; Galli, A, PLOS BIOLOGY, 5, 2369-2378 , (2007)

Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Williams, JM; Owens, WA; Turner, GH; Saunders, C; Dipace, C; Blakely, RD; France, CP; Gore, JC; Daws, LC; Avison, MJ; Galli, A, JOURNAL OF NEUROCHEMISTRY, 102, 9-10 , (2007)

Imaging Ligand-Gated Ion Channels with Quantun Dots. Tomlinson, ID; Orndorff, RL; Gussin H; Mason, JN; Blakely, RD; Pepperberg, DR; Rosenthal, SJ, PROCEEDINGS - SPIE, 6448, 64480X , (2007)

Model-guided exploration of the serotonin transporter: Evaluation of residues engaged in substrate binding and selectivity. Field, JR; Kaufmann, KW; Meiler, J; Blakely, RD, JOURNAL OF NEUROCHEMISTRY, 102, 45-45 , (2007)

Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. Zhu, CB; Steiner, JA; Munn, JL; Daws, LC; Hewlett, WA; Blakely, RD, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 322, 332-340 , (2007)

Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): A high affinity SERT ligand for conjugation to quantum dots. Tomlinson, ID; Warnerment, MR; Mason, JN; Vergne, MJ; Hercules, DM; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17, 5656-5660 , (2007)

Tegaserod inhibits the serotonin transporter SERT. Ismair, MG; Kullak-Ublick, GA; Blakely, RD; Fried, M; Vavricka, SR, DIGESTION, 75, 90-95 , (2007)

The dopamine transporter: A rare opportunity for progress in ADHD. Blakely, RD; Mazei-Robison, MM; Bowton, EA; Sakrikar, D; Gill, M; Freissmuth, M; Sitte, HH, BIOLOGICAL PSYCHIATRY, 61, 71 , (2007)

The functional impact of SLC6 transporter genetic variation. Hahn, MK; Blakely, RD, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 47, 401-441 , (2007)

Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. McDonald, PW; Hardie, SL; Jessen, TN; Carvelli, L; Matthies, DS; Blakely, RD, JOURNAL OF NEUROSCIENCE, 27, 14216-14227 , (2007)

A critical site in the human serotonin transporter defines Na plus and Cl-dependence. Henry, LK; Iwamoto, H; Dawson, E; Defelice, LJ; Blakely, RD, FASEB JOURNAL, 20, A242-A242 , (2006)

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Kim, CH; Hahn, MK; Joung, Y; Anderson, SL; Steele, AH; Mazei-Robinson, MS; Gizer, I; Teicher, MH; Cohen, BM; Robertson, D; Waldman, ID; Blakely, RD; Kim, KS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 19164-19169 , (2006)

Accelerated degradation of kinase proteins in depression. Shelton, R; Manier, DH; Blakely, R; Sanders-Bush, E, NEUROPSYCHOPHARMACOLOGY, 31, S257-S258 , (2006)

Activation of serotonin transporters by pro-inflamatory cytokines interleukin-1beta and tumor necrosis factor-alpha: A role of p38 MAPK. Zhu, CB; Hewlett, W; Blakely, R, ACTA PHARMACOLOGICA SINICA, 27, 358-358 , (2006)

Autism-associated serotonin transporter variants confer gain of function phenotypes arising through distinct mechanisms. Prasad, HC; Blakely, RD; Sutcliffe, JS, NEUROPSYCHOPHARMACOLOGY, 31, S82-S83 , (2006)

Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. Miner, LH; Jedema, HP; Moore, FW; Blakely, RD; Grace, AA; Sesack, SR, JOURNAL OF NEUROSCIENCE, 26, 1571-1578 , (2006)

Dopamine signaling architecture in Caenorhabditis elegans. McDonald, PW; Jessen, T; Field, JR; Blakely, RD, CELLULAR AND MOLECULAR NEUROBIOLOGY, 26, 593-618 , (2006)

Gene-gene interaction associated with drug response in unipolar major depression disorder. Motsinger, A; Haman, K; Hahn, M; Steele, A; English, B; Fentress, H; Myers, R; Hazelwood, L; Mazei, M; Sanders-Bush, E; Blakely, R; Ritchie, M; Shelton, R, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 141B, 706-707 , (2006)

Getting the message across: A recent transporter structure shows the way. Henry, LK; DeFelice, LJ; Blakely, RD, NEURON, 49, 791-796 , (2006)

High affinity inhibitors of the dopamine transporter (DAT): Novel biotinylated ligands for conjugation to quantum dots. Tomlinson, ID; Mason, JN; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 4664-4667 , (2006)

Identification of residues in the serotonin transporter engaged in high affinity recognition of antidepressants and cocaine. Field, JR; Henry, LK; Dawson, ES; Blakely, RD, FASEB JOURNAL, 20, A683-A683 , (2006)

Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: The proton inactivation hypothesis of hCHT in synaptic vesicles. Iwamoto, H; Blakely, RD; De Felice, LJ, JOURNAL OF NEUROSCIENCE, 26, 9851-9859 , (2006)

Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Keller, NR; Diedrich, A; Appalsamy, M; Miller, LC; Caron, MG; McDonald, MP; Shelton, RC; Blakely, RD; Robertson, D, NEUROSCIENCE, 139, 931-946 , (2006)

Proteomic analysis of human norepinephrine transporter complexes as a tool to identify biomarkers for antidepressant development. Sung, U; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 31, S236-S236 , (2006)

Regulation of serotonin transporters via cell signaling pathways and interacting proteins. Blakely, RD, ACTA PHARMACOLOGICA SINICA, 27, 49-49 , (2006)

Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro, AMD; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 24769-24780 , (2006)

The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. Matthies, DS; Fleming, PA; Wilkes, DM; Blakely, RD, JOURNAL OF NEUROSCIENCE, 26, 6200-6212 , (2006)

The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current. Binda, F; Lute, BJ; Dipace, C; Blakely, RD; Galli, A, NEUROPHARMACOLOGY, 50, 354-361 , (2006)

Turnover of kinase proteins in melancholic depression. Shelton, RC; Manier, DH; Blakely, R; Sanders-Bush, E, BIOLOGICAL PSYCHIATRY, 59, 809 , (2006)

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. Henry, LK; Field, JR; Adkins, EM; Parnas, ML; Vaughan, RA; Zou, MF; Newman, AH; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 2012-2023 , (2006)

A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. Nass, R; Hahn, MK; Jessen, T; McDonald, PW; Carvelli, L; Blakely, RD, JOURNAL OF NEUROCHEMISTRY, 94, 774-785 , (2005)

Allelic heterogeneity at the serotonin transporter gene confers risk for autism and rigid-compulsive behaviors. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; Han, Q; Jiang, L; Folstein, SE; Blakely, RD, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 138B, 71-71 , (2005)

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; McCauley, JL; Han, Q; Jiang, L; Li, C; Folstein, SE; Blakely, RD, AMERICAN JOURNAL OF HUMAN GENETICS, 77, 265-279 , (2005)

Amphetamine induces dopamine efflux through a dopamine transporter channel. Kahlig, KM; Binda, F; Khoshbouei, H; Blakely, RD; McMahon, DG; Javitch, JA; Galli, A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 3495-3500 , (2005)

Biogenic amine neurotransmitter transporters: Just when you thought you knew them. Blakely, RD; DeFelice, LJ; Galli, A, PHYSIOLOGY, 20, 225-231 , (2005)

Developmental expression of the high affinity choline transporter in cholinergic sympathetic neurons. Guidry, G; Willison, BD; Blakely, RD; Landis, SC; Habecker, BA, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 123, 54-61 , (2005)

Dysfunction of critical regulators of serotonergic signaling confers autism susceptibility. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; Han, Q; Jiang, L; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 30, S157-S157 , (2005)

Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Jayanthi, LD; Samuvel, DJ; Blakely, RD; Ramamoorthy, S, MOLECULAR PHARMACOLOGY, 67, 2077-2087 , (2005)

Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala. Mazei-Robison, MS; Blakely, RD, NEUROPHARMACOLOGY, 49, 737-749 , (2005)

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad, HC; Zhu, CB; McCauley, JL; Samuvel, DJ; Ramamoorthy, S; Shelton, RC; Hewlett, WA; Sutcliffe, JS; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 11545-11550 , (2005)

Inhibitors of the serotonin transporter protein (SERT): The design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots. Tomlinson, ID; Mason, JN; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15, 5307-5310 , (2005)

Labeling cell surface proteins via antibody quantum dot streptavidin conjugates. Mason, J; Tomlinson, I; Rosenthal, SJ; Blakely, R, NANOBIOTECHNOLOGY PROTOCOLS, Methods in Molecular Biology, 303, , (2005)

Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Egli, RE; Kash, TL; Choo, K; Savchenko, V; Matthews, RT; Blakely, RD; Winder, DG, NEUROPSYCHOPHARMACOLOGY, 30, 657-668 , (2005)

Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. Mason, JN; Farmer, H; Tomlinson, ID; Schwartz, JW; Savchenko, V; DeFelice, LJ; Rosenthal, SJ; Blakely, RD, JOURNAL OF NEUROSCIENCE METHODS, 143, 3-25 , (2005)

Overview: A rare opportunity or just one less reason to be depressed. Blakely, RD, NEURON, 48, 701-702 , (2005)

p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. Zhu, CB; Carneiro, AM; Dostmann, WR; Hewlett, WA; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 15649-15658 , (2005)

Peptide-conjugated quantum dots: imaging the angiotensin type 1 receptor in living cells. Tomlinson, ID; Mason, J; Blakely, RD; Rosenthal, SJ, NANOBIOTECHNOLOGY PROTOCOLS, Methods in Molecular Biology, 303, , (2005)

Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins. Sung, U; Jennings, JL; Link, AJ; Blakely, RD, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 333, 671-678 , (2005)

Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Mazei-Robison, MS; Couch, RS; Shelton, RC; Stein, MA; Blakely, RD, NEUROPHARMACOLOGY, 49, 724-736 , (2005)

Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. Fukumoto, T; Blakely, R; Levin, M, DEVELOPMENTAL NEUROSCIENCE, 27, 349-363 , (2005)

Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation. Hahn, MK; Mazei-Robison, MC; Blakely, RD, MOLECULAR PHARMACOLOGY, 68, 457-466 , (2005)

Surface modification to reduce nonspecific binding of quantum dots in live cell assays. Bentzen, EL; Tomlinson, ID; Mason, J; Gresch, P; Warnement, MR; Wright, D; Sanders-Bush, E; Blakely, R; Rosenthal, SJ, BIOCONJUGATE CHEMISTRY, 16, 1488-1494 , (2005)

The Quantum Dot Nanoconjugate Toolbox. Tomlinson, ID; Wright, DW; Giorgio, TD; Blakely, RD; Pennycook, SJ; Hercules, D; Bentzen, L; Smith, RA; McBride, J; Vergne, MJ; Rosenthal, SJ, PROGRESS IN BIOMEDICAL OPTICS AND IMAGING, 199, 5705 , (2005)

The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics. Meredith, EJ; Holder, MJ; Chamba, A; Challa, A; Lee, AD; Bunce, CM; Drayson, MT; Pilkington, G; Blakely, RD; Dyer, MJS; Barnes, NM; Gordon, J, FASEB JOURNAL, 19, 1187-+ , (2005)

A regulated association of the LIM domain protein Hic-5 with the antidepressant-sensitive serotonin transporter (SERT) in native tissues. Carneiro, AM; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 29, S177-S177 , (2004)

Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Proskocil, BJ; Sekhon, HS; Jia, YB; Savchenko, V; Blakely, RD; Lindstrom, J; Spindel, ER, ENDOCRINOLOGY, 145, 2498-2506 , (2004)

Adenosine receptor, protein kinase G and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu, CB; Hewlett, WA; Feoktistov, I; Biaggioni, I; Blakely, RD, MOLECULAR PHARMACOLOGY, 65, 1462-1474 , (2004)

Dopamine transporters depolarize neurons by a channel mechanism. Carvelli, L; McDonald, PW; Blakely, RD; DeFelice, LJ, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 16046-16051 , (2004)

Genotype-phenotype associations in unipolar major depression. Mazei-Robinson, M; Hazelwood, L; Myers, R; Prasad, H; Ritchie, M; Sanders-Bush, E; Shelton, R; Blakely, R, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B, 37-37 , (2004)

Identification and characterization of single nucleotide polymorphisms in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Mazei-Robison, MS; Blakely, RD, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B, 153-153 , (2004)

Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Ferguson, SM; Bazalakova, M; Savchenko, V; Tapia, JC; Wright, J; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 8762-8767 , (2004)

Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. McCauley, JL; Olson, LM; Dowd, M; Amin, T; Steele, A; Blakely, RD; Folstein, SE; Haines, JL; Sutcliffe, JS, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 127B, 104-112 , (2004)

Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Hoover, DB; Ganote, CE; Ferguson, SM; Blakely, RD; Parsons, RL, CARDIOVASCULAR RESEARCH, 62, 112-121 , (2004)

Modeling presynaptic cholinergic hypofunction: Pharmacological and behavioral studies in choline transporter heterozygous mice. Bazalakova, MH; Ferguson, SM; Wright, J; McDonald, MP; Blakely, RD, NEUROBIOLOGY OF AGING, 25, S248-S248 , (2004)

Monoamine genotype-phenotype relationships in depressed patients. Shelton, RC; Myers, R; Fentress, H; Mazei, MS; Prasad, H; Sanders-Bush, E; Blakely, R, BIOLOGICAL PSYCHIATRY, 55, 565 , (2004)

Regulation of choline transporter surface expression and phosphorylation by protein kinase C and protein phosphatase 1/2A. Gates, J; Ferguson, SM; Blakely, RD; Apparsundaram, S, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 310, 536-545 , (2004)

Serotonin transporter regulation: The inside story. Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 29, S37-S37 , (2004)

Signaling pathways supporting adenosine receptor-mediated 5-HT transport: trafficking dependent and independent modes. Zhu, CB; Hewlett, WA; Biaggioni, I; Feoktistov, I; Blakely, RD, FASEB JOURNAL, 18, A207-A207 , (2004)

Single channel recording in primary culture of C-elegans dopaminergic neurons.. Carvelli, L; Nass, R; McDonald, P; Blakely, RD; DeFelice, LJ, BIOPHYSICAL JOURNAL, 86, 548A-548A , (2004)

Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. Zhu, CB; Hewlett, WA; Francis, SH; Corbin, JD; Blakely, RD, EUROPEAN JOURNAL OF PHARMACOLOGY, 504, 1-6 , (2004)

The choline transporter resurfaces: New roles for synaptic vesicles?. Ferguson, SM; Blakely, RD, MOLECULAR INTERVENTIONS, 4, 22-37 , (2004)

The high-affinity choline transporter (CHT) functional variant 189v in Alzheimer's disease: An association study. Lee, SL; Lynch, B; Wang, J; Schnetz-Boutaud, N; Pericak-Vance, MA; Blakely, RD; Haines, JL, NEUROBIOLOGY OF AGING, 25, S516-S516 , (2004)

Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Liprando, LA; Miner, LH; Blakely, RD; Lewis, DA; Sesack, SR, SYNAPSE, 52, 233-244 , (2004)

Fluorescent nanocrystal probes for cell surface receptors.. Rosenthal, SJ; Tomlinson, I; Burton, J; Grey, J; Mason, J; Gresch, P; Sanders-Bush, E; DeFelice, L; Blakely, R, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 225, U522-U522 , (2003)

The design and synthesis of novel derivatives of the dopamine uptake inhibitors GBR 12909 and GBR 12935. High-affinity dopaminergic ligands for conjugation with highly fluorescent cadmium selenide/zinc sulfide core/shell nanocrystals. Tomlinson, ID; Mason, J; Burton, JN; Blakely, R; Rosenthal, SJ, TETRAHEDRON, 59, 8035-8047 , (2003)

Targeting cell surface receptors with ligand-conjugated nanocrystals. Rosenthal, SJ; Tomlinson, A; Adkins, EM; Schroeter, S; Adams, S; Swafford, L; McBride, J; Wang, YQ; DeFelice, LJ; Blakely, RD, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124, 4586-4594 , (2002)

Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Apparsundaram, S; Ferguson, SM; Blakely, RD, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 711-716 , (2001)


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