Click to return to the VINSE homepage
REU
Browse by Category:

Blakely, Randy D.
Allan D. Bass Professor of Pharmacology
Director, Silvio O. Conte Center for Neuroscience Research;
Vanderbilt Postdoctoral Training Program in Neurogenomics

Research Information

My laboratory explores the molecular basis for neurotransmitter transporter structure, function and regulation. We use chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. We are evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. We are also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.


Selected Publications

Biotin tethered homotryptamine derivatives: High affinity probes of the human serotonin transporter (hSERT). Tomlinson, ID; Iwamoto, H; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 1678-1682 , (2011)

Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans. Kohli, U; Hahn, MK; English, BA; Sofowora, GG; Muszkat, M; Li, C; Blakely, RD; Stein, CM; Kurnik, D, PHARMACOGENETICS AND GENOMICS, 21, 171-178 , (2011)

Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter. Thompson, BJ; Jessen, T; Henry, LK; Field, JR; Gamble, KL; Gresch, PJ; Carneiro, AM; Horton, RE; Chisnell, PJ; Belova, Y; McMahon, DG; Daws, LC; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 3785-3790 , (2011)

Antidepressant Action: From Molecule to Mouse to Man. Blakely, R, BIOLOGICAL PSYCHIATRY, 67, 1 , (2010)

Dependence of Serotonergic and Other Nonadrenergic Enteric Neurons on Norepinephrine Transporter Expression. Li, ZS; Caron, MG; Blakely, RD; Margolis, KG; Gershon, MD, JOURNAL OF NEUROSCIENCE, 30, 16730-16740 , (2010)

Dysregulation of Dopamine Transporters via Dopamine D-2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder. Bowton, E; Saunders, C; Erreger, K; Sakrikar, D; Matthies, HJ; Sen, N; Jessen, T; Colbran, RJ; Caron, MG; Javitch, JA; Blakely, RD; Galli, A, JOURNAL OF NEUROSCIENCE, 30, 6048-6057 , (2010)

Interleukin-1 Receptor Activation by Systemic Lipopolysaccharide Induces Behavioral Despair Linked to MAPK Regulation of CNS Serotonin Transporters. Zhu, CB; Lindler, KM; Owens, AW; Daws, LC; Blakely, RD; Hewlett, WA, NEUROPSYCHOPHARMACOLOGY, 35, 2510-2520 , (2010)

Monoamine Oxidase A-Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload. Kaludercic, N; Takimoto, E; Nagayama, T; Feng, N; Lai, EW; Bedja, D; Chen, K; Gabrielson, KL; Blakely, RD; Shih, JC; Pacak, K; Kass, DA; Di Lisa, F; Paolocci, N, CIRCULATION RESEARCH, 106, 193-U401 , (2010)

MOTOR NEURON-SPECIFIC OVEREXPRESSION OF THE PRESYNAPTIC CHOLINE TRANSPORTER IMPACT ON MOTOR ENDURANCE AND EVOKED MUSCLE ACTIVITY. Lund, D; Ruggiero, AM; Ferguson, SM; Wright, J; English, BA; Reisz, PA; Whitaker, SM; Peltier, AC; Blakely, RD, NEUROSCIENCE, 171, 1041-1053 , (2010)

Rab11 Supports Amphetamine-Stimulated Norepinephrine Transporter Trafficking. Matthies, HJG; Moore, JL; Saunders, C; Matthies, DS; Lapierre, LA; Goldenring, JR; Blakely, RD; Galli, A, JOURNAL OF NEUROSCIENCE, 30, 7863-7877 , (2010)

Transmembrane Domain 6 of the Human Serotonin Transporter Contributes to an Aqueously Accessible Binding Pocket for Serotonin and the Psychostimulant 3,4-Methylene Dioxymethamphetamine. Field, JR; Henry, LK; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 11270-11280 , (2010)

Ultrastructural Localization of High-Affinity Choline Transporter in the Rat Anteroventral Thalamus and Ventral Tegmental Area: Differences in Axon Morphology and Transporter Distribution. Holmstrand, EC; Asafu-Adjei, J; Sampson, AR; Blakely, RD; Sesack, SR, JOURNAL OF COMPARATIVE NEUROLOGY, 518, 1908-1924 , (2010)

A MODEL OF COGNITIVE DYSFUNCTION: CONSTRAINED DEMANDS ON CHOLINERGIC TRANSMISSION AND ATTENTIONAL CAPACITIES IN CHT+/- MICE. Parikh, V; Young, D; Cheema, A; Blakely, RD; Sarter, M, JOURNAL OF NEUROCHEMISTRY, 108, 71-72 , (2009)

Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. English, BA; Hahn, MK; Gizer, IR; Mazei-Robison, M; Steele, A; Kurnik, DM; Stein, MA; Waldman, ID; Blakely, RD, JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 1, 252-263 , (2009)

Enhanced activity of human serotonin transporter variants associated with autism. Prasad, HC; Steiner, JA; Sutcliffe, JS; Blakely, RD, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 364, 163-173 , (2009)

Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Carneiro, AMD; Airey, DC; Thompson, B; Zhu, CB; Lu, L; Chesler, EJ; Erikson, KM; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106, 2047-2052 , (2009)

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse. Veenstra-VanderWeele, J; Jessen, TN; Thompson, BJ; Carter, M; Prasad, HC; Steiner, JA; Sutcliffe, JS; Blakely, RD, JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 1, 158-171 , (2009)

Monoamine Oxidase A Promoter Gene Associated With Problem Behavior in Adults With Intellectual/Developmental Disabilities. May, ME; Srour, A; Hedges, LK; Lightfoot, DA; Phillips, JA; Blakely, RD; Kennedy, CH, AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES, 114, 269-273 , (2009)

NOREPINEPHRINE TRANSPORTER POLYMORPHISMS AFFECT BLOOD PRESSURE RESPONSE TO EXERCISE. Kohli, U; Hahn, MK; English, BA; Muszkat, M; Sofowora, GG; Blakely, RD; Stein, CM; Kurnik, D, CLINICAL PHARMACOLOGY & THERAPEUTICS, 85, S36-S37 , (2009)

NOREPINEPHRINE TRANSPORTER POLYMORPHISMS AFFECT BLOOD PRESSURE RESPONSE TO EXERCISE.. Kohli, U; Hahn, MK; English, BA; Muszkat, M; Sofowora, GG; Blakely, RD; Stein, CM; Kurnik, D, CLINICAL PHARMACOLOGY & THERAPEUTICS, 85, S2-S2 , (2009)

Psychiatric profile and attention deficits in postural tachycardia syndrome. Raj, V; Haman, KL; Raj, SR; Byrne, D; Blakely, RD; Biaggioni, I; Robertson, D; Shelton, RC, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 80, 339-344 , (2009)

Serotonin Rising. Anderson, GM; Cook, EH; Blakely, RD, NEW ENGLAND JOURNAL OF MEDICINE, 360, 2580-2580 , (2009)

Serotonin Transporter Expression Levels Differentially Regulate P-Selectin and Glycoprotein GpIIbIIIa. Carneiro, AM; Holinstat, M; Blakely, RD; Hamm, H, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29, E50-E50 , (2009)

Structural determinants of species-selective substrate recognition in human and Drosaphila serotonin transporters revealed through computational docking studies. Kaufmann, KW; Dawson, ES; Henry, LK; Field, JR; Blakely, RD; Meiler, J, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 74, 630-642 , (2009)

Subcellular localization of the antidepressant-sensitive norepinephrine transporter. Matthies, HJG; Han, Q; Shields, A; Wright, J; Moore, JL; Winder, DG; Galli, A; Blakely, RD, BMC NEUROSCIENCE, 10, 65 , (2009)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice. Misawa, H; Fujigaya, H; Nishimura, T; Moriwaki, Y; Okuda, T; Kawashima, K; Nakata, K; Ruggiero, AM; Blakely, RD; Nakatsu, F; Ohno, H, EUROPEAN JOURNAL OF NEUROSCIENCE, 27, 3109-3117 , (2008)

Anomalous dopamine release associated with a human dopamine transporter coding variant. Mazei-Robison, MS; Bowton, E; Holy, M; Schmudermaier, M; Freissmuth, M; Sitte, HH; Galli, A; Blakely, RD, JOURNAL OF NEUROSCIENCE, 28, 7040-7046 , (2008)

Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Hoard, JL; Hoover, DB; Mabe, AM; Blakely, RD; Feng, N; Paolocci, N, NEUROSCIENCE, 156, 129-142 , (2008)

Distinctions between dopamine transporter antagonists could be just around the bend. Henry, LK; Blakely, RD, MOLECULAR PHARMACOLOGY, 73, 616-618 , (2008)

Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Carvelli, L; Blakely, RD; DeFelice, LJ, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105, 14192-14197 , (2008)

Functional gene variation in the human norepinephrine transporter - Association with attention deficit hyperactivity disorder. Kim, CH; Waldman, ID; Blakely, RD; Kim, KS, MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION, 1129, 256-260 , (2008)

Going with the flow: Trafficking-dependent and -independent regulation of serotonin transport. Steiner, JA; Carneiro, AMD; Blakely, RD, TRAFFIC, 9, 1393-1402 , (2008)

Hereditary Spastic Paraplegia-Associated Mutations in the NIPA1 Gene and Its Caenorhabditis elegans Homolog Trigger Neural Degeneration In Vitro and In Vivo through a Gain-of-Function Mechanism. Zhao, JL; Matthies, DS; Botzolakis, EJ; Macdonald, RL; Blakely, RD; Hedera, P, JOURNAL OF NEUROSCIENCE, 28, 13938-13951 , (2008)

Interactions between integrin alpha IIb beta 3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro, AMD; Cook, EH; Murphy, DL; Blakely, RD, JOURNAL OF CLINICAL INVESTIGATION, 118, 1544-1552 , (2008)

Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression. Hahn, MK; Blackford, JU; Haman, K; Mazei-Robison, M; English, BA; Prasad, HC; Steele, A; Hazelwood, L; Fentress, HM; Myers, R; Blakely, RD; Sanders-Bush, E; Shelton, R, GENES BRAIN AND BEHAVIOR, 7, 487-495 , (2008)

Peripheral cytokine-inducers, LPS and poly I : C, upregulate CNS serotonin transporter (SERT) activity and induce depression-like Behavior in the mouse via a p38 mitogen-activated protein kinase (p38 MAPK) - Dependent mechanism. Zhu, CB; Blakely, RD; Hewlett, WA, BIOLOGICAL PSYCHIATRY, 63, 153 , (2008)

Quantum dot ex vivo labeling of neuromuscular synapses. Orndorff, RL; Warnement, MR; Mason, JN; Blakely, RD; Rosenthal, SJ, NANO LETTERS, 8, 780-785 , (2008)

Targetting the Human Serotoin Tranporter (hSERT) with Quantum Dots. Tomlinson, ID; Chang, J; Iwamoto, H; DeFelice, LJ; Blakely, RD; Rosenthal, SJ, PROCEEDINGS - SPIE, 6866, 6866-30 , (2008)

All aglow about presynaptic receptor regulation of neurotransmitter transporters. Blakely, RD; DeFelice, LJ, MOLECULAR PHARMACOLOGY, 71, 1206-1208 , (2007)

Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes. Dipace, C; Sung, U; Binda, F; Blakely, RD; Galli, A, MOLECULAR PHARMACOLOGY, 71, 230-239 , (2007)

Bound to be different: Neurotransmitter transporters meet their bacterial cousins. Henry, LK; Meiler, J; Blakely, RD, MOLECULAR INTERVENTIONS, 7, 306-309 , (2007)

Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A. Sung, U; Blakely, RD, MOLECULAR AND CELLULAR NEUROSCIENCE, 34, 251-260 , (2007)

Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice. Bazalakova, MH; Wright, J; Schneble, EJ; McDonald, MP; Heilman, CJ; Levey, AI; Blakely, RD, GENES BRAIN AND BEHAVIOR, 6, 411-424 , (2007)

Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. Mason, JN; Deecher, DC; Richmond, RL; Stack, G; Mahaney, PE; Trybulski, E; Winneker, RC; Blakely, RD, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 323, 720-729 , (2007)

Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Williams, J; Owens, WA; Turner, GH; Saunders, C; Dipace, C; Blakely, RD; France, CP; Gore, JC; Daws, LC; Avison, ML; Galli, A, PLOS BIOLOGY, 5, 2369-2378 , (2007)

Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. Williams, JM; Owens, WA; Turner, GH; Saunders, C; Dipace, C; Blakely, RD; France, CP; Gore, JC; Daws, LC; Avison, MJ; Galli, A, JOURNAL OF NEUROCHEMISTRY, 102, 9-10 , (2007)

Imaging Ligand-Gated Ion Channels with Quantun Dots. Tomlinson, ID; Orndorff, RL; Gussin H; Mason, JN; Blakely, RD; Pepperberg, DR; Rosenthal, SJ, PROCEEDINGS - SPIE, 6448, 64480X , (2007)

Model-guided exploration of the serotonin transporter: Evaluation of residues engaged in substrate binding and selectivity. Field, JR; Kaufmann, KW; Meiler, J; Blakely, RD, JOURNAL OF NEUROCHEMISTRY, 102, 45-45 , (2007)

Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. Zhu, CB; Steiner, JA; Munn, JL; Daws, LC; Hewlett, WA; Blakely, RD, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 322, 332-340 , (2007)

Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): A high affinity SERT ligand for conjugation to quantum dots. Tomlinson, ID; Warnerment, MR; Mason, JN; Vergne, MJ; Hercules, DM; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17, 5656-5660 , (2007)

Tegaserod inhibits the serotonin transporter SERT. Ismair, MG; Kullak-Ublick, GA; Blakely, RD; Fried, M; Vavricka, SR, DIGESTION, 75, 90-95 , (2007)

The dopamine transporter: A rare opportunity for progress in ADHD. Blakely, RD; Mazei-Robison, MM; Bowton, EA; Sakrikar, D; Gill, M; Freissmuth, M; Sitte, HH, BIOLOGICAL PSYCHIATRY, 61, 71 , (2007)

The functional impact of SLC6 transporter genetic variation. Hahn, MK; Blakely, RD, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 47, 401-441 , (2007)

Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. McDonald, PW; Hardie, SL; Jessen, TN; Carvelli, L; Matthies, DS; Blakely, RD, JOURNAL OF NEUROSCIENCE, 27, 14216-14227 , (2007)

A critical site in the human serotonin transporter defines Na plus and Cl-dependence. Henry, LK; Iwamoto, H; Dawson, E; Defelice, LJ; Blakely, RD, FASEB JOURNAL, 20, A242-A242 , (2006)

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Kim, CH; Hahn, MK; Joung, Y; Anderson, SL; Steele, AH; Mazei-Robinson, MS; Gizer, I; Teicher, MH; Cohen, BM; Robertson, D; Waldman, ID; Blakely, RD; Kim, KS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 19164-19169 , (2006)

Accelerated degradation of kinase proteins in depression. Shelton, R; Manier, DH; Blakely, R; Sanders-Bush, E, NEUROPSYCHOPHARMACOLOGY, 31, S257-S258 , (2006)

Activation of serotonin transporters by pro-inflamatory cytokines interleukin-1beta and tumor necrosis factor-alpha: A role of p38 MAPK. Zhu, CB; Hewlett, W; Blakely, R, ACTA PHARMACOLOGICA SINICA, 27, 358-358 , (2006)

Autism-associated serotonin transporter variants confer gain of function phenotypes arising through distinct mechanisms. Prasad, HC; Blakely, RD; Sutcliffe, JS, NEUROPSYCHOPHARMACOLOGY, 31, S82-S83 , (2006)

Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex. Miner, LH; Jedema, HP; Moore, FW; Blakely, RD; Grace, AA; Sesack, SR, JOURNAL OF NEUROSCIENCE, 26, 1571-1578 , (2006)

Dopamine signaling architecture in Caenorhabditis elegans. McDonald, PW; Jessen, T; Field, JR; Blakely, RD, CELLULAR AND MOLECULAR NEUROBIOLOGY, 26, 593-618 , (2006)

Gene-gene interaction associated with drug response in unipolar major depression disorder. Motsinger, A; Haman, K; Hahn, M; Steele, A; English, B; Fentress, H; Myers, R; Hazelwood, L; Mazei, M; Sanders-Bush, E; Blakely, R; Ritchie, M; Shelton, R, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 141B, 706-707 , (2006)

Getting the message across: A recent transporter structure shows the way. Henry, LK; DeFelice, LJ; Blakely, RD, NEURON, 49, 791-796 , (2006)

High affinity inhibitors of the dopamine transporter (DAT): Novel biotinylated ligands for conjugation to quantum dots. Tomlinson, ID; Mason, JN; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 4664-4667 , (2006)

Identification of residues in the serotonin transporter engaged in high affinity recognition of antidepressants and cocaine. Field, JR; Henry, LK; Dawson, ES; Blakely, RD, FASEB JOURNAL, 20, A683-A683 , (2006)

Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: The proton inactivation hypothesis of hCHT in synaptic vesicles. Iwamoto, H; Blakely, RD; De Felice, LJ, JOURNAL OF NEUROSCIENCE, 26, 9851-9859 , (2006)

Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Keller, NR; Diedrich, A; Appalsamy, M; Miller, LC; Caron, MG; McDonald, MP; Shelton, RC; Blakely, RD; Robertson, D, NEUROSCIENCE, 139, 931-946 , (2006)

Proteomic analysis of human norepinephrine transporter complexes as a tool to identify biomarkers for antidepressant development. Sung, U; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 31, S236-S236 , (2006)

Regulation of serotonin transporters via cell signaling pathways and interacting proteins. Blakely, RD, ACTA PHARMACOLOGICA SINICA, 27, 49-49 , (2006)

Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro, AMD; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 24769-24780 , (2006)

The Caenorhabditis elegans choline transporter CHO-1 sustains acetylcholine synthesis and motor function in an activity-dependent manner. Matthies, DS; Fleming, PA; Wilkes, DM; Blakely, RD, JOURNAL OF NEUROSCIENCE, 26, 6200-6212 , (2006)

The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current. Binda, F; Lute, BJ; Dipace, C; Blakely, RD; Galli, A, NEUROPHARMACOLOGY, 50, 354-361 , (2006)

Turnover of kinase proteins in melancholic depression. Shelton, RC; Manier, DH; Blakely, R; Sanders-Bush, E, BIOLOGICAL PSYCHIATRY, 59, 809 , (2006)

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. Henry, LK; Field, JR; Adkins, EM; Parnas, ML; Vaughan, RA; Zou, MF; Newman, AH; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 2012-2023 , (2006)

A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking. Nass, R; Hahn, MK; Jessen, T; McDonald, PW; Carvelli, L; Blakely, RD, JOURNAL OF NEUROCHEMISTRY, 94, 774-785 , (2005)

Allelic heterogeneity at the serotonin transporter gene confers risk for autism and rigid-compulsive behaviors. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; Han, Q; Jiang, L; Folstein, SE; Blakely, RD, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 138B, 71-71 , (2005)

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; McCauley, JL; Han, Q; Jiang, L; Li, C; Folstein, SE; Blakely, RD, AMERICAN JOURNAL OF HUMAN GENETICS, 77, 265-279 , (2005)

Amphetamine induces dopamine efflux through a dopamine transporter channel. Kahlig, KM; Binda, F; Khoshbouei, H; Blakely, RD; McMahon, DG; Javitch, JA; Galli, A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 3495-3500 , (2005)

Biogenic amine neurotransmitter transporters: Just when you thought you knew them. Blakely, RD; DeFelice, LJ; Galli, A, PHYSIOLOGY, 20, 225-231 , (2005)

Developmental expression of the high affinity choline transporter in cholinergic sympathetic neurons. Guidry, G; Willison, BD; Blakely, RD; Landis, SC; Habecker, BA, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 123, 54-61 , (2005)

Dysfunction of critical regulators of serotonergic signaling confers autism susceptibility. Sutcliffe, JS; Delahanty, RJ; Prasad, HC; Han, Q; Jiang, L; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 30, S157-S157 , (2005)

Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation. Jayanthi, LD; Samuvel, DJ; Blakely, RD; Ramamoorthy, S, MOLECULAR PHARMACOLOGY, 67, 2077-2087 , (2005)

Expression studies of naturally occurring human dopamine transporter variants identifies a novel state of transporter inactivation associated with Val382Ala. Mazei-Robison, MS; Blakely, RD, NEUROPHARMACOLOGY, 49, 737-749 , (2005)

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad, HC; Zhu, CB; McCauley, JL; Samuvel, DJ; Ramamoorthy, S; Shelton, RC; Hewlett, WA; Sutcliffe, JS; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 11545-11550 , (2005)

Inhibitors of the serotonin transporter protein (SERT): The design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indoles. High-affinity serotonergic ligands for conjugation with quantum dots. Tomlinson, ID; Mason, JN; Blakely, RD; Rosenthal, SJ, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15, 5307-5310 , (2005)

Labeling cell surface proteins via antibody quantum dot streptavidin conjugates. Mason, J; Tomlinson, I; Rosenthal, SJ; Blakely, R, NANOBIOTECHNOLOGY PROTOCOLS, Methods in Molecular Biology, 303, , (2005)

Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Egli, RE; Kash, TL; Choo, K; Savchenko, V; Matthews, RT; Blakely, RD; Winder, DG, NEUROPSYCHOPHARMACOLOGY, 30, 657-668 , (2005)

Novel fluorescence-based approaches for the study of biogenic amine transporter localization, activity, and regulation. Mason, JN; Farmer, H; Tomlinson, ID; Schwartz, JW; Savchenko, V; DeFelice, LJ; Rosenthal, SJ; Blakely, RD, JOURNAL OF NEUROSCIENCE METHODS, 143, 3-25 , (2005)

Overview: A rare opportunity or just one less reason to be depressed. Blakely, RD, NEURON, 48, 701-702 , (2005)

p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. Zhu, CB; Carneiro, AM; Dostmann, WR; Hewlett, WA; Blakely, RD, JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 15649-15658 , (2005)

Peptide-conjugated quantum dots: imaging the angiotensin type 1 receptor in living cells. Tomlinson, ID; Mason, J; Blakely, RD; Rosenthal, SJ, NANOBIOTECHNOLOGY PROTOCOLS, Methods in Molecular Biology, 303, , (2005)

Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins. Sung, U; Jennings, JL; Link, AJ; Blakely, RD, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 333, 671-678 , (2005)

Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Mazei-Robison, MS; Couch, RS; Shelton, RC; Stein, MA; Blakely, RD, NEUROPHARMACOLOGY, 49, 724-736 , (2005)

Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. Fukumoto, T; Blakely, R; Levin, M, DEVELOPMENTAL NEUROSCIENCE, 27, 349-363 , (2005)

Single nucleotide polymorphisms in the human norepinephrine transporter gene affect expression, trafficking, antidepressant interaction, and protein kinase C regulation. Hahn, MK; Mazei-Robison, MC; Blakely, RD, MOLECULAR PHARMACOLOGY, 68, 457-466 , (2005)

Surface modification to reduce nonspecific binding of quantum dots in live cell assays. Bentzen, EL; Tomlinson, ID; Mason, J; Gresch, P; Warnement, MR; Wright, D; Sanders-Bush, E; Blakely, R; Rosenthal, SJ, BIOCONJUGATE CHEMISTRY, 16, 1488-1494 , (2005)

The Quantum Dot Nanoconjugate Toolbox. Tomlinson, ID; Wright, DW; Giorgio, TD; Blakely, RD; Pennycook, SJ; Hercules, D; Bentzen, L; Smith, RA; McBride, J; Vergne, MJ; Rosenthal, SJ, PROGRESS IN BIOMEDICAL OPTICS AND IMAGING, 199, 5705 , (2005)

The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics. Meredith, EJ; Holder, MJ; Chamba, A; Challa, A; Lee, AD; Bunce, CM; Drayson, MT; Pilkington, G; Blakely, RD; Dyer, MJS; Barnes, NM; Gordon, J, FASEB JOURNAL, 19, 1187-+ , (2005)

A regulated association of the LIM domain protein Hic-5 with the antidepressant-sensitive serotonin transporter (SERT) in native tissues. Carneiro, AM; Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 29, S177-S177 , (2004)

Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Proskocil, BJ; Sekhon, HS; Jia, YB; Savchenko, V; Blakely, RD; Lindstrom, J; Spindel, ER, ENDOCRINOLOGY, 145, 2498-2506 , (2004)

Adenosine receptor, protein kinase G and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Zhu, CB; Hewlett, WA; Feoktistov, I; Biaggioni, I; Blakely, RD, MOLECULAR PHARMACOLOGY, 65, 1462-1474 , (2004)

Dopamine transporters depolarize neurons by a channel mechanism. Carvelli, L; McDonald, PW; Blakely, RD; DeFelice, LJ, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 16046-16051 , (2004)

Genotype-phenotype associations in unipolar major depression. Mazei-Robinson, M; Hazelwood, L; Myers, R; Prasad, H; Ritchie, M; Sanders-Bush, E; Shelton, R; Blakely, R, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B, 37-37 , (2004)

Identification and characterization of single nucleotide polymorphisms in the human dopamine transporter gene in children with attention deficit hyperactivity disorder. Mazei-Robison, MS; Blakely, RD, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 130B, 153-153 , (2004)

Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Ferguson, SM; Bazalakova, M; Savchenko, V; Tapia, JC; Wright, J; Blakely, RD, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 8762-8767 , (2004)

Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. McCauley, JL; Olson, LM; Dowd, M; Amin, T; Steele, A; Blakely, RD; Folstein, SE; Haines, JL; Sutcliffe, JS, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 127B, 104-112 , (2004)

Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Hoover, DB; Ganote, CE; Ferguson, SM; Blakely, RD; Parsons, RL, CARDIOVASCULAR RESEARCH, 62, 112-121 , (2004)

Modeling presynaptic cholinergic hypofunction: Pharmacological and behavioral studies in choline transporter heterozygous mice. Bazalakova, MH; Ferguson, SM; Wright, J; McDonald, MP; Blakely, RD, NEUROBIOLOGY OF AGING, 25, S248-S248 , (2004)

Monoamine genotype-phenotype relationships in depressed patients. Shelton, RC; Myers, R; Fentress, H; Mazei, MS; Prasad, H; Sanders-Bush, E; Blakely, R, BIOLOGICAL PSYCHIATRY, 55, 565 , (2004)

Regulation of choline transporter surface expression and phosphorylation by protein kinase C and protein phosphatase 1/2A. Gates, J; Ferguson, SM; Blakely, RD; Apparsundaram, S, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 310, 536-545 , (2004)

Serotonin transporter regulation: The inside story. Blakely, RD, NEUROPSYCHOPHARMACOLOGY, 29, S37-S37 , (2004)

Signaling pathways supporting adenosine receptor-mediated 5-HT transport: trafficking dependent and independent modes. Zhu, CB; Hewlett, WA; Biaggioni, I; Feoktistov, I; Blakely, RD, FASEB JOURNAL, 18, A207-A207 , (2004)

Single channel recording in primary culture of C-elegans dopaminergic neurons.. Carvelli, L; Nass, R; McDonald, P; Blakely, RD; DeFelice, LJ, BIOPHYSICAL JOURNAL, 86, 548A-548A , (2004)

Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil. Zhu, CB; Hewlett, WA; Francis, SH; Corbin, JD; Blakely, RD, EUROPEAN JOURNAL OF PHARMACOLOGY, 504, 1-6 , (2004)

The choline transporter resurfaces: New roles for synaptic vesicles?. Ferguson, SM; Blakely, RD, MOLECULAR INTERVENTIONS, 4, 22-37 , (2004)

The high-affinity choline transporter (CHT) functional variant 189v in Alzheimer's disease: An association study. Lee, SL; Lynch, B; Wang, J; Schnetz-Boutaud, N; Pericak-Vance, MA; Blakely, RD; Haines, JL, NEUROBIOLOGY OF AGING, 25, S516-S516 , (2004)

Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area. Liprando, LA; Miner, LH; Blakely, RD; Lewis, DA; Sesack, SR, SYNAPSE, 52, 233-244 , (2004)

Fluorescent nanocrystal probes for cell surface receptors.. Rosenthal, SJ; Tomlinson, I; Burton, J; Grey, J; Mason, J; Gresch, P; Sanders-Bush, E; DeFelice, L; Blakely, R, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 225, U522-U522 , (2003)

The design and synthesis of novel derivatives of the dopamine uptake inhibitors GBR 12909 and GBR 12935. High-affinity dopaminergic ligands for conjugation with highly fluorescent cadmium selenide/zinc sulfide core/shell nanocrystals. Tomlinson, ID; Mason, J; Burton, JN; Blakely, R; Rosenthal, SJ, TETRAHEDRON, 59, 8035-8047 , (2003)

Targeting cell surface receptors with ligand-conjugated nanocrystals. Rosenthal, SJ; Tomlinson, A; Adkins, EM; Schroeter, S; Adams, S; Swafford, L; McBride, J; Wang, YQ; DeFelice, LJ; Blakely, RD, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124, 4586-4594 , (2002)

Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Apparsundaram, S; Ferguson, SM; Blakely, RD, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 711-716 , (2001)


Phone: 615-936-3705
Email: randy.blakely@vanderbilt.edu
Website: Click to Visit

 
Vanderbilt University