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Harth, Eva M.
Associate Professor of Chemistry
Associate Professor of Pharmacology

Research Information

The overreaching goal of our research is the development of versatile platforms of innovative vectors for cancer therapeutics, vaccine development and imaging reagents in nanomedicine. With the growing sophistication of polymerization strategies, the implementation of functionality and utilization of macromolecular architectures will be key for many of the promising applications in nanotechnology related to the biomedical field and materials science. Thereby structural and functional fidelity compatible for bioconjugation is a focus in the design of the polymer topology. 

    1.) Design and Synthesis of 3-D Multifunctional well-defined Nanoscale Objects. We develop multifunctional organic nanoparticles of degradable and non-degradable nature to enable the controlled attachment of targeting units, molecular transporter, therapeutics and/or imaging reagents. 

    2.) A new Generation of Molecular Transporter. Considering the low efficiency of cellular transport, we investigate dendritic molecular transporter of unique design to allow the delivery of bioactive cargos specifically to the cytosol or nucleus without unwanted intracellular probe metabolism and transport.
    The systemic combination of nanovectors with preferred therapeutics, targeting moieties and vectors for cellular uptake provides the opportunity to obtain a large number of personalized therapeutic reagents. 

    3.) Towards organic 'quantum dots- Approaches to novel semiconducting Nanoparticles. In demand of imaging probes correlated with the efficacy of drug carriers, well-defined nanoparticles are developed for in vivo imaging and device technologies. They contain fluorescent core units and are decorated with lanthanides to provide powerful  bimodal imaging reagents and will vitalize the investigation of electronic properties through site-isolation effects of electroactive entities in well-defined nanoobjects.

Selected Publications

Non-viral siRNA delivery vectors: dendritic molecular transporter and molecular transporter nanovectors for target gene silencing. Hamilton, SK; Sims, AL; Donavan, J; Harth, E, POLYMER CHEMISTRY, 2, 441-446 , (2011)

"Click" Reactions: Novel Chemistries for Forming Well-defined Polyester Nanoparticles. van der Ende, AE; Harrell, J; Sathiyakumar, V; Meschievitz, M; Katz, J; Adcock, K; Harth, E, MACROMOLECULES, 43, 5665-5671 , (2010)

Anti-Vascular Endothelial Growth Factor Treatment in Combination with Chemotherapy Delays Hematopoietic Recovery Due to Decreased Proliferation of Bone Marrow Hematopoietic Progenitor Cells. Novitskiy, SV; Csiki, I; Huang, YH; Johnson, DH; Harth, EM; Carbone, DP; Dikov, MM, JOURNAL OF THORACIC ONCOLOGY, 5, 1410-1415 , (2010)

Linear release nanoparticle devices for advanced targeted cancer therapies with increased efficacy. van der Ende, AE; Sathiyakumar, V; Diaz, R; Hallahan, DE; Harth, E, POLYMER CHEMISTRY, 1, 93-96 , (2010)

Targeted Nanoparticles That Deliver a Sustained, Specific Release of Paclitaxel to Irradiated Tumors. Passarella, RJ; Spratt, DE; van der Ende, AE; Phillips, JG; Wu, HM; Sathiyakumar, V; Zhou, L; Hallahan, DE; Harth, E; Diaz, R, CANCER RESEARCH, 70, 4550-4559 , (2010)

A Novel Targeting Ligand for X-ray-guided Drug Delivery. Phillips, JG; Passarella, RJ; Van der Ende, A; Zhou, L; Wu, H; Harth, E; Hallahan, D; Diaz, R, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, S92-S92 , (2009)

Molecular Dendritic Transporter Nanoparticle Vectors Provide Efficient Intracellular Delivery of Peptides. Hamilton, SK; Harth, E, ACS NANO, 3, 402-410 , (2009)

Nanoparticles with Individual Site-Isolated Semiconducting Polymers from Intramolecular Chain Collapse Processes. Adkins, CT; Muchalski, H; Harth, E, MACROMOLECULES, 42, 5786-5792 , (2009)

Tailored polyester nanoparticles: post-modification with dendritic transporter and targeting units via reductive amination and thiol-ene chemistry. van der Ende, A; Croce, T; Hamilton, S; Sathiyakumar, V; Harth, E, SOFT MATTER, 5, 1417-1425 , (2009)

Approach to formation of multifunctional polyester particles in controlled nanoscopic dimensions. van der Ende, AE; Kravitz, EJ; Harth, E, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130, 8706-8713 , (2008)

Controlled electrophoretic deposition of uniquely nanostructured star polymer films. Somarajan, S; Hasan, SA; Adkins, CT; Harth, E; Dickerson, JH, JOURNAL OF PHYSICAL CHEMISTRY B, 112, 23-28 , (2008)

Effective delivery of IgG-antibodies into infected cells via dendritic molecular transporter conjugate IgGMT. Hamilton, SK; Ikizler, MR; Wallen, C; Wright, PF; Harth, E, MOLECULAR BIOSYSTEMS, 4, 1209-1211 , (2008)

Synthesis of star polymer architectures with site-isolated chromophore cores. Adkins, CT; Harth, E, MACROMOLECULES, 41, 3472-3480 , (2008)

Alternative o-quinodimethane cross-linking precursors for intramolecular chain collapse nanoparticles. Croce, TA; Hamilton, SK; Chen, ML; Muchalski, H; Harth, E, MACROMOLECULES, 40, 6028-6031 , (2007)

Dendritic molecular transporters provide control of delivery to intracellular compartments. Huang, K; Voss, B; Kumar, D; Hamm, HE; Harth, E, BIOCONJUGATE CHEMISTRY, 18, 403-409 , (2007)

Effective drug therapies from functional, macromolecular building blocks with a biomimetic design. Huang, K; Croce, TA; Hamilton, SK; Adkins, CT; Evans BL; Harth, E, MACRMOL SYMP, 255, 20-23 , (2007)

Radiation guided peptide targeting to tumor microvasculature using nanoparticle carriers. Hariri, G; Croce, T; Harth, E; Han, Z; Tantawy, N; Peterson, T; Baldwin, R; Hallahan, D, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69, S151-S152 , (2007)

Approaches in the development of 3-D nanoscopic, multifunctional vectors. Croce, TA; Muchalski, H; Adkins, CT; Huang, K; Hamilton, SK; van der Ende, A; Harth, E, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 231, , (2006)

Carving out niches for nanostructures:Implementation and interplay of building blocks, methods and tools
. Harth, E; Croce, TA, AUSTRALIAN JOURNAL OF CHEMISTRY, 59, 525-533 , (2006)

Covalent stabilization of nanostrcutres: Robust block copolymer templates from novel thermoreactive systems. Drockenmuller, E; Li, LYT; Ryu, DY; Harth, E; Russell, TP; Kim, HC, Hawker, CJ, JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 43, 1028-1037 , (2005)

Strategies and synthesis of suitable precursors for the construction of 3-D bioactive scaffolds. Croce, TA; Funk, M; Adkins, CT; Harth, E, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 230, U3664-U3665 , (2005)

Synthesis of amino acid-based polymers via atom transfer radical polymerization in aqueous media at ambient temperature. Chung, ID; Britt, P; Xie, D; Harth, E; Mays, J, CHEMICAL COMMUNICATIONS, , 1046-1048 , (2005)

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