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VINSE - Vanderbilt Institute of Nanoscale Science and Engineering

VINSE - Vanderbilt Institute of Nanoscale Science and Engineering
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John T. Wilson

Associate Professor of Chemical and Biomolecular Engineering
Associate Professor of Biomedical Engineering

Overview:

In the Wilson group we work at the interface of engineering and immunology to improve human health. We bring together expertise in colloid and surface engineering, polymer science, nanotechnology and drug delivery to develop innovative molecularly engineered materials for modulating immune responses. We are currently developing synthetic nanovaccine platforms, injectable biomaterials for cancer immunotherapy, and delivery systems for immunomodulatory nucleic acid therapeutics.

Awards:

• National Science Foundation CAREER Award
• Melanoma Research Alliance Young Investigator Award
• Stand Up To Cancer (SU2C) Innovation Research Grant Award
• Littlejohn Family Faculty Fellow
• Alex’s Lemonade Stand Foundation ‘A’ Award
• 2019 Emerging Investigator, Biomaterials Science
• Cancer Research Institute Irvington Postdoctoral Fellowship

Selected Publications:

A sweeter approach to vaccine design. Wilson, JT, SCIENCE, 363, 584-585 , (2019)

Delivery of 5 '-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy. Jacobson, ME; Wang-Bishop, L; Becker, KW; Wilson, JT, BIOMATERIALS SCIENCE, 7, 547-559 , (2019) View Abstract

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy. Shae, D; Becker, KW; Christov, P; Yun, DS; Lytton-Jean, AKR; Sevimli, S; Ascano, M; Kelley, M; Johnson, DB; Balko, JM; Wilson, JT, NATURE NANOTECHNOLOGY, 14, 269-+ , (2019) View Abstract

Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs. Palmer, CR; Jacobson, ME; Fedorova, O; Pyle, AM; Wilson, JT, BIOCONJUGATE CHEMISTRY, 29, 742-747 , (2018) View Abstract

Poly(propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines. Qiu, F; Becker, KW; Knight, FC; Baljon, JJ; Sevimli, S; Shae, D; Gilchuk, P; Joyce, S; Wilson, JT, BIOMATERIALS, 182, 82-91 , (2018) View Abstract