April 15, 2009FRONTIERS IN MATERIALS SCIENCE
VINSE COLLOQUIUM SERIES
Dr. Rashid Bashir
"Interfacing Silicon and Biology at the Micro and Nanoscale: Opportunities and Prospects"
Abstract. Nanotechnology and BioMEMS will have a significant impact on medicine and biology in the areas of single cell detection, diagnosis and combating disease, providing specificity of drug delivery for therapy, and avoiding time consuming steps to provide faster results and solutions to the patient. Integration of biology and silicon at the micro and nano scale offers tremendous opportunities for solving important problems in biology and medicine and to enable a wide range of applications in diagnostics, therapeutics, and tissue engineering. In this talk, we will present an overview of our work in Silicon-Based BioMEMS and Bionanotechnology and discuss the state of the art and the future challenges and opportunities. We will review a range of projects in our group integrating micro-systems engineering with biology, focused towards developing rapid detection of biological entities and developing point of care devices using electrical or mechanical phenomenon at the micro and nano scale. Towards this end, we will present our work on developing silicon-based petri dishes-on-a-chip, silicon based nano-pores for detection of DNA, silicon field-effect sensors for detection of DNA and proteins, and use of mechanical sensors for characterization of living cells.