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REU

October 30, 2013

FRONTIERS IN MATERIALS SCIENCE
VINSE COLLOQUIUM SERIES

Dr. Prabhas V. Moghe
Rutgers University
Distinguished Professor of
Biomedical Engineering &
Chemical & Biochemical Engineering

“THE EMERGENCE OF NANOMEDICINE:NANOLIPOBLOCKERS AS A DISRUPTIVE PARADIGM OF
THERAPEUTIC MATERIALS?”
4:10 pm, 5326 Stevenson Center (refreshments at 3:45)

Abstract:  The uncontrolled accumulation of oxidized low-density lipoproteins (LDL) within the walls of blood vessels, called atherosclerosis, lies at the core of cardiovascular diseases and, coupled with other risk factors, causes a staggering toll on adult mortality and rising health care costs.  We have been investigating the possibility of engineering nanoscale biomaterials as anti-atherosclerotic therapeutics for inhibiting cholesterol accumulation and the related inflammation.  A generation of unimers whose surface features such as surface anionic density; amphiphilicity; and nanoscale architecture can be systematically varied was designed.  We report that assemblies of such nanolipoblockers (NLBs) can systematically block the scavenger receptor molecules that traffic highly oxidized LDL into macrophages and inhibit the resulting atherogenic phenotype.  In parallel, a multimodal strategy of depleting cellular cholesterol was examined by using the NLBs as drug delivery carriers in vivo. The NLBs lowered intimal levels of accumulated cholesterol and inhibited macrophage retention relative to non-treated controls.  A number of more recent project directions, including studies of molecular mechanisms of action, design of more stable nanoparticle formulations of the NLBs, and emergent pathways for translational medicine will also be highlighted in this talk.

Host: Hak Joon Sung


Dr. Prabhas V. Moghe
 
Vanderbilt University