Click to return to the VINSE homepage
REU

December 12, 2012

FRONTIERS IN MATERIALS SCIENCE
VINSE COLLOQUIUM SERIES

Gang Han
Assistant Professor of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
4:10 pm, 5326 Stevenson Center
3:45 pm Refreshments, 5326 Stevenson Center Hallway
Host: Qi Zhang

“Beyond Fluorescence: Small and Bright Upconversion Nanoparticles for Biological Imaging”

 Lanthanide-doped upconversion luminescent nanoparticles (UCNPs) are promising materials for in vitro and in vivo optical imaging due to their unique optical and chemical properties. UCNPs absorb low energy near-infrared (NIR) light and emit high-energy shorter wavelength photons. Their special features allow them to overcome various problems associated with conventional imaging probes. In this talk, I will present a new type of biocompatible UCNP. They are free of autofluorescence for in vitro cell imaging, and exhibit significantly improved signal-to-noise-ratio (i.e., 300 for Balb-c mice) and outstanding tissue penetration depth (>3cm) , and minimal light scattering, all highly desired for in vivo whole animal imaging.  I will also present a new development regarding about engineering UCNPs towards in vivo photounacging .





Gang Han
 
Vanderbilt University