12th Annual Nanoscience and Nanotechnology Forum
12th Annual Nanoscience and Nanotechnology Forum
Wednesday, November 9
Buttrick Hall *all Nanoday events will be held in Buttrick Hall lobby and room 101, the John R. and Donna S. Hall Engineering Lecture will be held in Featheringill Hall
Schedule of Events
1:30 - 2:00 POSTER SESSION and REFRESHMENTS
2:00 - 2:10 Welcome Sandra Rosenthal, Chemistry
2:10 - 2:30 Hybrid Nanoparticles: Two mysteries and a twist at the end Janet Macdonald, Chemistry
2:30 - 2:50 Application of Functionalized Quantum Dot in Neurobiology Qi Zhang, Pharmacology
2:50 - 3:10 Nanoparticle film formation by electrophoretic deposition James Dickerson, Physics
3:10 - 3:30 Thermal Transport through van der Waals Interfaces between Nanostructures Yang Yang,
Graduate Student, Deyu Li's Group
4:00 - 5:00 John R. and Donna S. Hall Engineering Lecture
"ARPA-E: Catalyzing Energy Breakthroughs for a Secure American Future” Arun Majumdar, Ph.D.
Director of the Advanced Research Projects Agency - Energy (ARPA-E)
5:00 - 6:00 DINNER AND POSTER SESSION - Buttrick Hall
6:00 - 7:00 KEYNOTE SPEAKER
Co-opting Moore's Law: Vaccines and Medicines Made from a Wafer Joseph M. DeSimone,
University of North Carolina, Chapel Hill
7:00 RECEPTION AND POSTER AWARDS - Buttrick Hall
DeSimone Abstract. In 1965, Gordon Moore, co-founder of Intel, described the trend that the number of components in integrated circuits had doubled every year since 1958. This trend has continued to today, enabled by advances in photolithography which has taken the minimum feature size of transistors down from about 10 microns in 1970 to 0.045 microns (45 nm) today. In biological terms, this corresponds to going from the size of a red blood cell to the size of a single virus particle! As such, this top-down nano-fabrication technology from the semiconductor industry is, for the first time, in the size range to be relevant for the design of medicines, vaccines and interfacially active Janus particles. This lecture will describe the design, synthesis and efficacy of organic nano- and micro-particles using a top-down nano-fabrication technique we developed called PRINT (Particle Replication in Non-wetting Templates). PRINT is a continuous, roll-to-roll, high resolution molding technique that allows the fabrication of precisely defined micro- and nano-particles in a continuous manner with control over chemical composition, size, shape, deformability and surface chemistry. With these ‘nanotools’, we are establishing definitive biodistribution maps to elucidate the interdependent roles that size, shape, deformability and surface chemistry play on particle distribution as a function of different dosage forms (IV, IP, inhaled, subcutaneous, intramuscular, etc). This information is setting the stage for the design of highly effective chemo-therapeutics, chemo-preventions and cancer vaccines which will be described.
DeSimone Bio. Joseph DeSimone is the Chancellor’s Eminent Professor of Chemistry at the University of North Carolina at Chapel Hill and William R. Kenan Jr. Professor of Chemical Engineering at North Carolina State University. DeSimone is also an Adjunct Member at Memorial Sloan-Kettering Cancer Center in New York. DeSimone has published over 270 scientific articles and has 120 issued patents in his name with over 120 patents pending. In 2005 DeSimone was elected into the National Academy of Engineering and the American Academy of Arts and Sciences.
DeSimone has received over 40 major awards and recognitions including the 2010 AAAS Mentor Award, the 2009 NIH Director’s Pioneer Award, the 2009 North Carolina Award, and the 2008 Lemelson-MIT Prize for Invention and Innovation. In 2002 DeSimone, along with Dr. Richard Stack (Duke University) and Dr. Robert Langer (MIT), co-founded Bioabsorbable Vascular Solutions (BVS) to commercialize a fully bioabsorbable, drug-eluting stent. The stent achieved CE Mark approval in Europe in 2011 and is being further evaluated in a series of international clinical trials led by Abbott for the treatment of coronary artery disease.
DeSimone’s group is now heavily focused on harnessing the fabrication technologies from the semiconductor industry to design high-performance, cost-effective vaccines and medicines. DeSimone and his team have developed a roll-to-roll particle fabrication technology called PRINT (Particle Replication in Non-wetting Templates). They are exploiting the advantages of PRINT to generate “calibration quality” nano-tools to define the geometric (size, shape), surface (zeta potential, stealthing ligands), and deformability limitations for the effective delivery of drugs and vaccines. DeSimone recently launched Liquidia Technologies (www.liquidia.com), which employs roughly 60 people in Research Triangle Park, North Carolina and has raised over $60 million in venture financing, including the first ever equity investment by the Bill and Melinda Gates Foundation in a for-profit biotech company. Liquidia has converted PRINT into a GMP compliant process and has recently brought its first product, a seasonal influenza vaccine based on PRINT particles, into its first clinical trial. DeSimone received his BS in Chemistry in 1986 from Ursinus College in Collegeville, PA and his Ph.D. in Chemistry in 1990 from Virginia Tech.
Current Poster Submissions for 2011
1. "Characterization of ion implantation-induced defects in diamond lattices by coherent acoustic phonon spectroscopy"
Presented by: Justin Gregory, Interdisciplinary Materials Science (Tolk)
2. "Composite fuel cell membranes from dual-nanofiber electrospun mats"
Presented by: Jason Ballengee, Chemical and Biomolecular Engineering (Pintauro)
3. "Biphasic adsorbents for air purification: post-synthetic modification of structured silicas"
Presented by: Amanda Furtado, Chemical and Biomolecular Engineering (Levan)
4. "Electrochemical investigation on the impact of various redox mediators on the photoresponse of a photosystem I modified electrode"
Presented by: Gongping Chen, Chemistry (Cliffel)
5. "Photosystem I-based solar cell"
Presented by: Darlene Gunther, Interdisciplinary Materials Science (Jennings)
6. "Microfluidic production of 18F-labeled TSPO ligands"
Presented by: Matthew Hight, Interdisciplinary Materials Science (Manning)
7. "Creating defects in suspended and supported graphene FET devices"
Presented by: Shuren Hu, Physics (Bolotin)
8. "Off-chip photomultiplier-based continuous flow photometer 'Channelscope™' system for the detection of programmed immuno-agglomerates in fabrica**"
Presented by: Andre Stevenson, Biomedical Engineering Undergraduate (Giorgio)
9. "Constructing gold nanocages through thermal annealing"
Presented by: Junhao Lin, Physics (Dickerson)
10. "Macrophage-targeted siRNA delivery for cancer therapy"
Presented by: Cheryl Lau, Biomedical Engineering Undergraduate (Giorgio)
11. "Enabling ultrasensitive mass and force sensing with graphene mechanical resonators"
Presented by: Hiram Conley, Physics (Bolotin)
12. "Plasmon-mediated emission from GLAD-functionalized ZnO nanowires"
Presented by: Daniel Mayo, Physics, Fisk University (Mu/Haglund)
13. "Photoreduction of platinum particles onto multilayer films of photosystem I"
Presented by: Gabriel LeBlanc, Chemistry (Cliffel)
14. "Injectable scaffolds for the sustained delivery of pH-responsive nanoparticles"
Presented by: Chris Nelson, Biomedical Engineering (Duvall)
15. "Dynamics of laser induced phase transitions of VO2 films"
Presented by: Victor Diez Blanco, Physics (Haglund)
16. "Stacking fault energy measurements in Fe-Mn-Al-Si twinning induced plasticity steels"
Presented by: Dean Pierce, Interdisciplinary Materials Science (Wittig)
17. "Interaction between photoexcited quantum dots and graphene"
Presented by: Dhiraj Prasai, Interdisciplinary Materials Science (Bolotin)
18. "Molecular yransporter as a platform for the delivery of antibodies and plasmid DNA into cells"
Presented by: Artez Sims, Chemistry (Harth)
19. "Picomolar sensitive depth resolved imaging of gold nanorods with photothermal optical coherence tomography"
Presented by: Jason Tucker-Schwartz, Biomedical Engineering (Skala)
20. "Robust and cost-effective method for the fabrication of phase-change materials VO2: Effect of growth conditions on the switching and morphological properties"
Presented by: Robert Marvel, Interdisciplinary Materials Science (Haglund)
21. "Analysis of lattice thermal conductivity in carbon nanotubes"
Presented by: Ebonee Walker, Interdisciplinary Materials Science (Walker)
22. "Quantum transport in carbon and crossbar nanostructures"
Presented by: Brandon Cook, Physics (Varga)
23. "Detection of nanoscale size dependence in VO2 phase transition by metamaterial nanosensors"
Presented by: Kannatassen Appavoo, Interdisciplinary Materials Science (Haglund)
24. "Accelerated oxidation of silicon due to x-ray irradiation"
Presented by: Shweta Bhandaru, Interdisciplinary Materials Science (Weiss)
25. "Nanostructure analysis of diamond cold cathode electron field emitters"
Presented by: Travis Wade, Interdisciplinary Materials Science (Davidson/Tolk)
26. "Electrospinning carbon nanotubes with polymers to improve electroconductivity of fiber mesh scaffolds"
Presented by: Yi Liang, Biomedical Engineering Undergraduate (Sung)
27. "Characterization of multilayered polymeric systems via second harmonic generation laser spectroscopy by example of piezoelectric polyvinylidene fluoride"
Presented by: Jennifer Jones, Physics Fisk (Mu/Tolk)
28. "Extraction of disease biomarkers using surface tension valves"
Presented by: Nick Adams, Chemistry (Wright)
29. "Phosphors as sensors for radiation-induced displacement damage"
Presented by: Sarah Gollub, Interdisciplinary Materials Science (Walker)
30. "Grating coupled waveguide biosenor based on porous silicon"
Presented by: Xing Wei, Electrical Engineering (Weiss)
31. "Optimization of multi-walled carbon nanotube photon absorbers for mid and far-infrared stray light suppression"
Presented by: John Rigueur, Interdisciplinary Materials Science (Burger/Hanusa)
32. "Malaria coffee ring diagnostics"
Presented by: Keersten Davis, Chemistry (Wright)
33. "Innovative flexible, mucoadhesive, multilayer polymeric thin films as key solution for local therapy in the gastrointestional tract"
Presented by: Virginia Pensabene, Post-Doctoral Associate, Biomedical Engineering (Giorgio)
34. "Amphilphilic diblock polymer micelles for oxidation-dependent drug delivery"
Presented by: Mukesh Kumar Gupta, Post-Doctoral Associate, Biomedical Engineering (Duvall)
35. "Strongly-correlated electron interactions within Gold::Vanadium dioxide nanocomposites"
Presented by: Davon Ferrara, Post-Doctoral Associate, Physics (Haglund)
36. "Porous silicon films with tunable diffusion coefficients for controlled drug release"
Presented by: Jeremy Mares, Post-Doctoral Associate, Electrical Engineering (Weiss)
37. "Single quantum dot analysis of dopamine transporter trafficking"
Presented by: Oleg Kovtun, Chemistry (Rosenthal)
1st year student posters submission for 2011
1 (RS). "Surface Functionalization of Mesoporous Silicon Nanoparticles for siRNA Delivery"
Presented by: Kelsey Beavers, Interdisciplinary Materials Science (Duvall/Weiss)
2 (RS). "Manipulating light with metallic and dielectric metamaterials"
Presented by: Yuanmu Yang, Interdisciplinary Materials Science (Valentine)
3 (RS). "Langmuir-Blodgett Photosystem I Monolayers"
Presented by: Yiliang Zhao, Interdisciplinary Materials Science (Cliffel)