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Kevin T. Seale - Publications

 

Peer-Reviewed Publications

JP Wikswo, FE Block, DE Cliffel, CR Goodwin, CC Marasco, DA Markov, DL McLean, JA McLean, JR McKenzie, RS Reiserer, PC Samson, DK Schaffer, KT Seale, SD Sherrod, Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems, IEEE Trans. Biomed. Eng., 2013, 60:682-690 doi:10.1109/TBME.2013.2244891

S Chowdhury, P Svec, C Wang, W Losert, KT Seale, JP Wikswo, SK Gupta, Investigation of Automated Cell Manipulation in Optical Tweezers-Assisted Microfluidic Chamber Using Simulations, Proceedings of the ASME International Design Engineering Technical Conference & Computers and Information in Engineering Conference, Washington, D.C., (August 28-31, 2011)

JR Enders, CR Goodwin, CC Marasco, KT Seale, JP Wikswo, JA McLean, Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from Haystacks, LCGC and Spectroscopy 2011 Supplement Series: Current Trends in Mass Spectrometry, July 18-23, 2011 (Invited)

S Darby, M Moore, JP Wikswo, R Reiserer, T Friedlander, DK Schaffer, KT Seale, A Metering Rotary Nanopump for Microfluidic Systems, Lab Chip, 2010, 10:3218-3226 doi:10.1039/C0LC00087F

JR Enders, A Kole, B Nguyen, S Sundarapandian, CC Marasco, KT Seale, JP Wikswo, JA McLean, Towards Monitoring Real-Time Cellular Response Using an Integrated Microfluidics-Matrix Assisted Laser Desorption Ionisation/Nanoelectrospray Ionisation-Ion Mobility-Mass Spectrometry Platform, IET Syst. Biol., 2010, 4:416-427 doi:10.1049/iet-syb.2010.0012

K Seale, S Faley, J Chamberlain, JP Wikswo, Macro to Nano: A Simple Method for Transporting Cultured Cells from Milliliter Scale to Nanoliter Scale, Exp. Biol. Med., 2010, 235:777-783 doi:10.1258/ebm.2010.009379

K Seale, C Janetopoulos, J Wikswo, Perspective on "Micromirrors for Nanoscale Three-Dimensional Microscopy", ACS Nano, 2009, 3:493-497 doi:10.1021/nn900188t

SL Faley, M Copland, D Wlodkowic, W Kolch, KT Seale, JP Wikswo, JM CooperMicrofluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-Derived Hematopoietic Stem Cells, Lab Chip, 2009, 9:2659-2664 doi:10.1039/b902083g

KT Seale, R Reiserer, D Markov, I Ges, C Wright, C Janetopoulos, JP Wikswo, Mirrored Pyramidal Wells for Simultaneous Multiple Vantage Point Microscopy, J. Microsc., 2008, 232, Pt 1:1-6  doi:10.1111/j.1365-2818.2008.02110.x,

S Faley, K Seale, J Hughey, DK Schaffer, S VanCompernolle, B McKinney, F Baudenbacher, D Unutmaz, JP Wikswo, Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel, Lab Chip, 2008, 8:1700-1712 doi:10.1039/b719799c

JJ Hughey, JP Wikswo and KT Seale, Intra-Microfluidic Pinocytic Loading of Human T Cells.  IEEE/NIH Life Sciences Systems and Applications, Annual Meeting, Bethesda, MD, November 2007, Conference Proceedings.  DOI

McQuain MK, Seale KT, Peek J, Fisher TS, Levy S, Stremler MA, Haselton FR., Chaotic mixer improves microarray hybridization. Anal Biochem. 2004 Feb 15;325(2):215-26.  PMID: 14751256

McQuain MK, Seale KT, Peek J, Levy S, Haselton FR., Effects of relative humidity and buffer additives on the contact printing of microarrays by quill pins. Anal Biochem. 2003 Sep 15;320(2):281-91.  PMID: 12927835

Seale KT, Pou NA, Krivitski N, Harris TR., Quantification of lung microvascular injury with ultrasound. Ann Biomed Eng. 2002 May;30(5):671-82.   PMID: 12108841

Seale KT, Harris TR., A three-compartment model of osmotic water exchange in the lung microvasculature. Ann Biomed Eng. 2000 Aug;28(8):1019-27.  PMID: 11144663

Other Publications and Presentations

K Seale, P Armstrong, J Wikswo, The Systems Biology and Bioengineering Undergraduate Research Experience at Vanderbilt University, 2009 ASEE Southeast Section Conference, http://155.225.14.146/asee-se/proceedings/ASEE2009/papers/PR2009098SEA.PDF 

EGR Kim, P Sivasubramaniam, JP Wikswo, KT Seale, Differential Optical Flow for Automated Cell Motility, MicroTAS Tech Digest 2008: Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, LE Locascio, ed., Chemical and Biological Microsystems Society, San Diego, CA, October 12-16, 2008, 1831-1833

Seale, K, Peer Review and the Publication of science, Annals of Biomedical Student/Postdoc Training Research, and Current Topics, Issue 2, 4-5, Spring 2008

KT Seale, Cyborg Cells, Creating Life in the Laboratory? Current Events Editorial, Annals of Biomedical Student/Postdoc Training, Research, and Current Topics, Issue 1, Fall 2007.

KT Seale, BA McKinney, PR Norris, SL Faley and JP Wikswo, Nanophysiometry: Linking Function to Genomics Via Continuous Physiological Monitoring of Single Cells Fifth Symposium on the Functional Genomics of Critical Illness and Injury, November 2007, Awarded Platform Presentation.

KT Seale, R Reiserer, JW Chamberlain, C. Janetopoulos and JP Wikswo, Multiple Vantage Point Microscopy Using Mirrored Pyramidal Wells. BMES Annual Fall Meeting, September 2007, Platform Presentation.

JW Chamberlain, JP Wikswo and KT Seale, Long-Term Cytokinesis Studies Studies Of Human T Cell Populations in a Microfluidic Device. Biomedical Engineering Society Annual Fall Meeting, September 2007, Poster Presentation.

EG. Kim, JP Wikswo and KT Seale, Quantification of Cell Motion in a Microfludic Device. Biomedical Engineering Society Annual Fall Meeting, September 2007, Poster Presentation.

JJ Hughey, JP Wikswo and KT Seale, Intra-Microfluidic Pinocytic Loading of Jurkat T Cells. Biomedical Engineering Society Annual Fall Meeting, September 2007, Poster Presentation.

KT Seale, R Reiserer, D Markov, I Ges, C Janetopoulos and J Wikswo, Simultaneous Multi-Perspective Three Dimensional Microscopy with Mirrored Pyramidal Wells. Focus on Microscopy International Symposium, April 2007, Valencia, Spain, Platform Presentation.

S Faley, KT Seale, J Hughey, D Unutmaz, F Baudenbacher, J Wikswo, Novel Microfluidic Platform for the Analysis of T Cell Signaling Pathways. SPIE Biophotonics West, San Jose, January 2007, Platform Presentation.

KT Seale, J Wikswo, BioMEMS Methods for Cell Biology. Vanderbilt Ingram Cancer Center Annual Fall Retreat, November 2007, Platform Presentation.

C Wright, K. Seale, R. Reiserer, E Boczko, C Stowers and  J Wikswo, Using Micromirrors to Obtain Three Dimensional Images of Cells. 117th Annual Meeting of the Tennessee Academy of Sciences, November 2007, Platform Presentation.

E. Kim, K Seale and J Wikswo, Quantification of the Motion of Non-Adherent Cells in a Microfluidic Device. 74th Annual Meeting of the Southeastern Section of the American Physical Society, November 2007, Platform Presentation.

C Wright, E Boczko, J Wikswo, K Seale, Novel micromirrors to obtain three-dimensional images of cells. 74th Annual Meeting of the Southeastern Section of the American Physical Society, November 2007, Platform Presentation.

KT Seale, S Faley, J Hughey, B McKinney, D Unutmaz, F Baudenbacher, J Wikswo, Automated Parallel Measurement of Signaling Events in Single T Cells Using a Novel Nanophysiometer. Biomedical Engineering Society Annual Fall Meeting, October, 2006, Platform Presentation.

KT Seale, R Reiserer, D Markov, I Ges, J Wikswo, BioMEMS Micromirror Wells for High Resolution Simultaneous Three Dimensional Imaging of Cells. Biomedical Engineering Society Annual Fall Meeting, October, 2006, Platform Presentation.

S Faley, KT Seale, J Hughey, D Unutmaz, J Wikswo, Novel Microfluidic Platform for the Analysis of T Cell Signaling Pathways. Biomedical Engineering Society Annual Fall Meeting, October, 2006, Platform Presentation.

KT Seale, S Faley, J Hughey, D Unutmaz, F Baudenbacher, J Wikswo, Poster: Automated Detection and Analysis of  T-cell intracellular calcium using a nanophysiometer. NIH Frontiers in Live Cell Imaging meeting. April, 2006. Bethesda, MD.

BioMEMS Methods for Cell Biology Vanderbilt Department of Cancer Biology Retreat, Selected Speaker, November 2006.

A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings. Microbiology and Immunology Journal Club Guest Speaker, Vanderbilt University Medical Center, October 2006.

Baysian Inference of Cell Signaling Causality, Microbiology and Immunology Journal Club Guest Speaker, Vanderbilt University Medical Center, February 2006.

Instrumentation and Control for Quantitative, Experimental Systems Biology, Microbiology and Immunology Journal Club Guest Speaker, Vanderbilt University Medical Center, August 2005.

DNA Microarrays: Past Present and Future, BME Department Guest Speaker Seminar, Vanderbilt University, 2004.

King KR, KT Seale, TR Harris, Visualization-based analysis of a pulmonary capillary osmotic model, FASEB J. 13(4, Part I): A423, 1999.

Minimally invasive measurement of lung vascular transport properties: a mathematical model for the measurement of osmotic exchange with ultrasound, Physiome Symposium, Seattle, 1999.

Measurement of Filtration and Reflection Coefficients of Lung Microvasculature, TN BME, Memphis, 1998.

KT Seale, Book Review - Flow-Dependent Regulation of Vascular Function. IEEE Engineering in Medicine and Biology, 16(5):179-180, 1997.

KT Seale, S Bosan, JM Dendy, SU Adams, NA Pou, N Krivitski, TR Harris, Osmotic transport coefficients decrease significantly with vascular injury in dog lungs. FASEB J. 11(3):A129, 1997.

EGR Kim, JP Wikswo and KT Seale, Cytokinetic Toximetry In a Microfluidic Device. 117th Annual Meeting of the Tennessee Academy of Sciences, November 2007, Platform Presentation.

Quantitation of Osmotic Exchange Coefficients with Ultrasound, BMES, San Diego, 1997.

Measurement of Lung Injury with Ultrasound, FASEB Annual Meeting, New Orleans, 1997.

KT Seale, Book Review - The Electrical Engineering Handbook. IEEE Engineering in Medicine and Biology, 15(6):136-137, 1996.

A Three-Compartment Model of the Lung Microvasculature, FASEB Annual Meeting, Washington, 1996.


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Kevin Seale

B.S. - University of Georgia, Athens GA, 1993
M.S. - Biomedical Engineering, Vanderbilt University, 1996  >
Ph.D.- Biomedical Engineering, Vanderbilt University, 2000  


Contact Information:  

Vanderbilt Institute for Integrative Biosystems Research and Education
VU Station B 351807 (U.S.P.S)
6301 Stevenson Center (UPS etc.)
Nashville, TN 37235-1807 USA 
Ph: (615) 322-2569 x4
Fax: (615) 322-4977
email: kevin.t.seale@vanderbilt.edu