Vanderbilt Institute of Chemical Biology

 

 

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VICB 2017-2018 Fall-Winter Seminar Schedule

 

 

Fall 2017
Seminar Schedule


Margaret Chu-Moyer

Amgen

 

"Making Sense of Pain: A Human Genetics Driven Multi-Disciplinary, Multi-Modality Approach to Drug Discovery" 

 

Wednesday, September 6, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

Recent advances in human genetics have allowed deeper insight into disease biology. Coupling of this to the development of molecules to further understand relevant pharmacology and to identify potential therapeutics has never been more important or more challenging. This lecture will demonstrate the scientific interplay that is necessary to discover human medicines using a recent multi-modality example from our Neuroscience portfolio (Nav1.7 inhibitors for treatment of pain) and will include discussion of target validation, structural biology, lead optimization in medicinal chemistry and pharmacokinetic/pharmacodynamics relationships.

Lars Plate

Vanderbilt university

 

"Targeting Proteostasis to Treat Amyloid Diseases" 

 

Wednesday, September 13, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Selective activation of Unfolded Protein Response (UPR)-associated transcription factors enhances ER quality control of destabilized proteins associated with amyloid diseases.
· High-throughput screening identifies selective small-molecule activators of distinct UPR-associated transcriptional programs.
· Mass spectrometry-based interactomics uncovers the mechanisms of enhanced ER quality control, revealing emergent properties of ER proteostasis pathways.

Alexander Hoffmann

UCLA

 

"Specificity and Noise in NFB Signaling"

 

Wednesday, September 20, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Iterative experimental studies and mathematical modeling have revealed how NFkB dynamics are produced by several negative feedback loops with distinct functions.
· Single cell studies reveal much heterogeneity, and in conjunction with modeling we can identify the sources of the molecular network noise.
· How NFkB dynamics control differential gene expression responses in innate immunity, or cell fate decisions in adaptive immunity are major ongoing questions.

John Engen

northeastern University

 

"Hydrogen Exchange Mass Spectrometry to Probe the Conformation of Proteins"

 

Wednesday, September 27, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Co-Sponsored by CBAS and V-CBI

 

Key Lecture Points

· Analysis of protein conformation in solution
· Can reveal structural changes during function/binding
· Being used heavily by biopharmaceutical industry

Wonhwa Cho

university of illinois - chicago

 

"New Signaling Roles of Cholesterol"

 

Wednesday, October 4, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· In situ quantitative imaging shows transbilayer asymmetry of plasma membrane cholesterol
· Stimulus-induced transbilayer redistribution of cholesterol mediates various cellular responses.
· Dysregulated cholesterol dynamics is linked to cancer.

Borden Lacy

Vanderbilt university

 

"Structures and Functions of the Clostridium Difficile Toxins TcdA and TcdB"

 

Wednesday, October 11, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· TcdA and TcdB toxins cause cell intoxication and the clinical manifestations of Clostridium difficile infection.

· The TcdA and TcdB toxins and the pathways they hijack within the host represent targets for therapeutic intervention.

· The structures and mechanisms of action for 4 neutralizing antibodies will be presented.

Sunney Xie

harvard university

 

1st Seminar: "Single Cell Genomics: When Stochasticity Meets Precision"

 

Co-Sponsored by The Vanderbilt Biophotonics Center

 

Wednesday, October 18, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· A new method for single cell whole genome amplification supersedes previous methods.
· A new method for single cell transcriptome with high detection efficiency and accuracy allows for extraction of transcriptional regulatory networks
acting within a particular cell type from cell-to-cell stochastic fluctuations under the nonequilibrium steady state condition.
· A new single cell chromatin conformation capture method yields the first 3D genome map of a human diploid cell.
· Applications and implications to biology and medicine of these new approaches will be discussed.

 

2nd Seminar: "Stimulated Raman Scattering Microscopy for Biology and Medicine"

 

Wednesday, October 19, 2017

12:15 P.M. — 1:15 P.M.

Location TBD

Richard Glennon

virginia commonwealth university

 

"Drug Discrimination: Applications in CNS Drug Research"

 

Wednesday, October 25, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Behavioral assay using, primarily, rats to classify centrally-acting agents and to investigate their mechanisms of action of action.
· Application of drug discrimination in drug design.
· Use of drug discrimination to study actions of metabolites.

Ryan Altman

University of Kansas

 

"Decarboxylative Fluoroalkylation and Fluorinated Peptidomimetic Biological Probes"

 

Wednesday, November 1, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Research Summary

· New synthetic methods allow access to fluorinated substructures for medicinal chemistry and chemical biology.

· Fluoroalkenes have unique physicochemical properties that can be exploited for synthetic and medicinal chemistry.

· Fluorinated peptidomimetics stabilize and improve blood-brain-barrier permeability of endogenous neuropeptides.

Armen Zakarian

University of california- Santa barbara

 

"Total Synthesis of Cyanotoxins with Precise Isotopic Signatures"

 

Wednesday, November 8, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Lecture Summary

Isotopically labeled compounds have many uses, one of which is as standards for detection quantification of analytes by isotope-dilution mass spectrometry. A main problem is access to standards. Total synthesis of complex compounds with isotope labels on meaningful scales will be presented.

Robert Garbaccio

merck

 

"An Antibody-Drug Conjugate Approach to Tissue-Selective Glucocorticoids" 

 

Wednesday, November 15, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

·Modality agnostic drug discovery means bringing the best modality to a given biological target
· Peptide, oligonucleotide and bioconjugate modalities realizing increasing clinical success and address complex biology
· Organic and medicinal chemists have an important role to play in the discovery and optimization of these alternative modalities
· The targeted delivery of glucocorticoids to immune cells represents an exciting challenge for chemists to develop novel linker and payload strategies

  Winter-Spring 2018
Seminar Schedule

Xi Chen

UC Davis

 

"TBA"

 

Wednesday, January 17, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Yi Tang

UCLA

 

"Unraveling the Chemical Logic of Complex Natural Product Biosynthesis"  

 

Wednesday, January 31, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Synthetic Biology
· Drug Discovery

James Bradner

novartis institutes for biomedical research

 

"TBA"

 

Wednesday, February 7, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Carole Bewley

nih-niddk

 

"TBA"

 

Wednesday, February 14, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Sam Gellman

university of wisconSin - madison

 

"TBA"

 

Wednesday, February 21, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Brad Pentelute

MIT

 

"TBA"

 

Wednesday, February 28, 2018

4:00 - 5:25 P.M.

208 Light Hall

Paul Lieberman

WISTAR INSTITUTE

 

"TBA"

 

Wednesday, March 7, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Luke Lavis

hhmi - janelia

 

"TBA"

 

Wednesday, March 14, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

K. C. Nicolaou

rice university

 

Andrew Myers

Harvard university

 

"TBA"

 

Co-Sponsored by the Department of Chemistry

 

Wednesday, March 28, 2018

12:15 P.M. — 1:15 P.M.

214 Light Hall

Susanne Rafelski

allen Institute for Cell science

 

"TBA"

 

Wednesday, April 4, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Co-Sponsored by CBAS and V-CBI

 

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