Vanderbilt Institute of Chemical Biology

 

 

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VICB 2017-2018 Fall-Winter Seminar Schedule

 

 

Fall 2017
Seminar Schedule


Margaret Chu-Moyer

Amgen

 

"Making Sense of Pain: A Human Genetics Driven Multi-Disciplinary, Multi-Modality Approach to Drug Discovery" 

 

Wednesday, September 6, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

Recent advances in human genetics have allowed deeper insight into disease biology. Coupling of this to the development of molecules to further understand relevant pharmacology and to identify potential therapeutics has never been more important or more challenging. This lecture will demonstrate the scientific interplay that is necessary to discover human medicines using a recent multi-modality example from our Neuroscience portfolio (Nav1.7 inhibitors for treatment of pain) and will include discussion of target validation, structural biology, lead optimization in medicinal chemistry and pharmacokinetic/pharmacodynamics relationships.

Geert-Jan Boons

University of georgia

 

"TBA"  

 

Wednesday, September 13, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

Alexander Hoffmann

UCLA

 

"Specificity and Noise in NFB Signaling"

 

Wednesday, September 20, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Iterative experimental studies and mathematical modeling have revealed how NFkB dynamics are produced by several negative feedback loops with distinct functions.
· Single cell studies reveal much heterogeneity, and in conjunction with modeling we can identify the sources of the molecular network noise.
· How NFkB dynamics control differential gene expression responses in innate immunity, or cell fate decisions in adaptive immunity are major ongoing questions.

John Engen

northeastern University

 

"Hydrogen Exchange Mass Spectrometry to Probe the Conformation of Proteins"

 

Key Lecture Points

· Analysis of protein conformation in solution
· Can reveal structural changes during function/binding
· Being used heavily by biopharmaceutical industry

 

Wednesday, September 27, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

Wonhwa Cho

university of illinois - chicago

 

"New Signaling Roles of Cholesterol"

 

Key Lecture Points

· In situ quantitative imaging shows transbilayer asymmetry of plasma membrane cholesterol
· Stimulus-induced transbilayer redistribution of cholesterol mediates various cellular responses.
· Dysregulated cholesterol dynamics is linked to cancer.

 

Wednesday, October 4, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

Armen Zakarian

University of california- Santa barbara

 

"TBA"

 

Wednesday, November 8, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

Robert Garbaccio

merck

 

"TBA" 

 

Wednesday, November 15, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

R. Daniel Beauchamp

Vanderbilt universit medical center

 

"TBA"

 

Wednesday, November 29, 2017

12:15 P.M. — 1:15 P.M.

1220 MRB III

  Winter-Spring 2018
Seminar Schedule

Yi Tang

UCLA

 

"Unraveling the Chemical Logic of Complex Natural Product Biosynthesis"  

 

Wednesday, January 31, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

Key Lecture Points

· Synthetic Biology
· Drug Discovery

James Bradner

novartis institutes for biomedical research

 

"TBA"

 

Wednesday, February 7, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Sam Gellman

university of wisconSin - madison

 

"TBA"

 

Wednesday, February 21, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Brad Pentelute

MIT

 

"TBA"

 

Wednesday, February 28, 2018

4:00 - 5:25 P.M.

208 Light Hall

Paul Lieberman

WISTAR INSTITUTE

 

"TBA"

 

Wednesday, March 7, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Luke Lavis

hhmi - janelia

 

"TBA"

 

Wednesday, March 14, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Andrew Myers

Harvard university

 

"TBA"

 

Wednesday, March 21, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

K. C. Nicolaou

rice university

 

"TBA"

 

Wednesday, March 28, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

Susanne Rafelski

allen Institute for Cell science

 

"TBA"

 

Wednesday, April 4, 2018

12:15 P.M. — 1:15 P.M.

1220 MRB III

 

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