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Discoveries

Infectious Disease Mechanisms and Antimicrobial Drug Discovery

Targeting Flu Through A Host Protein August 20, 2014
Two-Component System Cross-Talk in the Anthrax Pathogen —  April 4, 2014
Exploring the Dynamics of Proton-Driven Multidrug Transporter
—  December 16, 2013
Clostridium difficile Hijacks Cellular Production of Reactive Oxygen Species to Kill Its Host —  November 13, 2013
Combatting Antibiotic Drug Resistance —  September 26, 2013
Dissecting the Molecular Pathogenesis of Bone Infection by Staphylococcus aureus —  July 2, 2013
Discovery of Antibacterial Activity Targeting Fermenting Staphylococcus aureus —  May 7, 2013
Anatomy Of A Neurotoxin —  April 9, 2013
Biomarking Infection with BSI —  April 1, 2013
Combatting Bacteria by Manganese Sequestration —  March 4, 2013
Metabolic Response to Antibiotic Resistance —  February 1, 2013
Visualizing Infection —  July 18, 2012
Human Versus Staphylococcus: The Fight for Iron January 5, 2011
How a Bacterial Toxin Causes Diarrhea August 6, 2010
Key to Virulence of Meningitis Bacterium April 8, 2010
Investigating the Mad Cow Prion March 14, 2010

Cancer Biology and Cancer Drug Discovery
What Drives Cancer? —  July 28, 2014
Visualizing Cell Death In Vivo —  March 25, 2014
A New Approach to Targeting Ras —  February 27, 2014
A Stapled Peptide Probe of Replication Protein A’s Protein-Protein Interactions —  December 12, 2013
Targeting Glioblastoma Through Phospholipase D
— December 2, 2013
Discovery of an Inhibitor of Replication Protein A’s Protein-Protein Interactions
—  October 30, 2013
Windorphen: A New Wnt Signaling Inhibitor —  September 23, 2013
Discovery of Mcl-1 Inhibitors Offer Hope for New Cancer Therapeutics —  January 8, 2013
Targeting Cancer Through K-Ras —  May 29, 2012
Personalizing the Effects of Therapy —  January 24, 2012
Targeted Imaging Agent Puts the Focus on Cancer —  October 12, 2011
The Seven Signatures of Triple Negative Breast Cancer June 24, 2011
Stopping Cancer Cell Invasion February 25, 2011
New Tool in the Fight Against Colon Cancer November 1, 2010
Novel Approach to Fight Cancer September 23, 2010
Fighting Cancer with Nanotechnology July 15, 2010
Of Wingless Flies and Cancer — April 26, 2010

Neuroscience and Neuroscience Drug Discovery
Tackling Anxiety
— July 21, 2014
New Class of Cyclooxygenase Inhibitors with Anti-Anxiety Activity
— August 7, 2013
A Potassium Channel Activator Possesses Anticonvulsant Activity
—  June 9, 2013
Cholesterol and the Brain —  June 19, 2012
Nanoscience Meets Drug Discovery —  March 7, 2012
New Tricks for Some Old Drugs —  October 19, 2011

Therapeutic Discovery – Other Targets
Bacteria to the Rescue!
June 30, 2014
Antioxidant Therapy Provides Hope for Smith-Lemli-Opitz Syndrome
—  August 5, 2013
A New Drug Discovery Program Targeting Obesity Receives NIH Funding —  July 23, 2013
New Tool To Combat Heart Disease —  December 9, 2011
The Search for Novel Drugs Goes Underground January 14, 2011
Drug Discovery Focuses On Fish — February 5, 2010

Combatting Malaria
Honing the Sensitivity of Malaria Diagnosis —  May 6, 2014
Linking the Sense of Smell to Reproduction in Anopheles gambiae Mosquitoes —  February 10, 2014
Potassium Channel Inhibition as a New Insecticide Target for Mosquito Control —  June 10, 2013
Odorant Receptor Expression Directs Behavior in Anopheles gambiae Mosquitoes
—  May 14, 2013
Sniffing out New Ways to Combat Malaria May 19, 2011
On the Scent of the Malaria Mosquito — February 19, 2010


DNA Replication, Damage, and Repair
Identifying the Elusive Protein-DNA Cross-Link —  October 22, 2013
SV40 Virus Co-Opts the Host DNA Damage Response —  April 30, 2013
A New Structural Framework for Replication Protein A (RPA)s —  January 28, 2013
Bypassing A Toxic DNA Adduct: A Look Into The Enzyme Active Site —  October 11, 201
A  Closer Look at DNA Replication with iPOND July 14, 2011
AlkD's Novel Approach to DNA Repair October 29, 2010
Prime Time for DNA Replication
August 27, 2010



Biochemistry

Bioengineering
Constructing a Biosynthetic Pathway in Reverse March 28, 2014
Harnessing the Circadian Clock to Boost Useful Bioproduction in Cyanobacteria November 20, 2013

Lipids
Tracking The Reactive Electrophile August 5, 2014
Biochemical Collaboration Leads to Novel Biologically Active Lipids
April 25, 2011
Are Your Lipids Stressed Out? — January 25, 2010

Mechanisms of Cytotoxicity
Histones as Electrophile Targets — August 22, 2014
Functional Impact of Proteint Modification by Lipid Electrophiles
— January 30, 2014

Signaling
Energetics of the Activated Receptor-G Protein Interaction —  December 13, 2013
Probing Arrestin Conformation —  November 5, 2012
New Insights into G-Protein-Receptor Coupling June 10, 2011

Proteins
Bromide Ion is Essential for Life June 24, 2014
Bringing Order to Chaos
—  April 25, 2014
Sulfilimine Cross-Links: A Key to Tissue Evolution —  January 2, 2014
Key to Collagen Cross-Links —  August 28, 2012
Protein Symmetry by Design —  October 18, 2011
Backscattering Interferometry - Shining Light on Protein-Ligand Interactions March 28, 2011

Transcription
How MicroRNAs Modulate Gene Expression —  April 12, 2013
Survival Advantage Conveyed by Non-Optimal Codon Usage
—  February 26, 2013


Novel Chemistry
Reversing Polarity to Conserve Chirality June 24, 2010
Nature's Approach to Solar Power March 3, 2010


 

 

 

 

 



Vanderbilt Institute of Chemical Biology Researchers Report Their Latest Findings at the Forefront of Chemical Biology

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