Vanderbilt has a rich assortment of core facilities that provide access to techniques and equipment at the frontiers of biomedical research. Researchers have rapid and reliable access to a wide spectrum of support facilities that make doing chemical biology research at Vanderbilt a seamless, in-house operation. Synthesis of small molecules for the biologist, antibody production for use by chemists, rapid identification of structure using NMR and MS facilities, high level modeling of protein-drug interactions and final proof of concept using the HTS core are all part of the collaborative, interdisciplinary work environment at the VICB. The VICB operates:
Small Molecule NMR Core
This core facility provides researchers access to five modern superconducting Bruker nuclear magnetic resonance (NMR) spectrometers ranging from field strengths of 7.1 T (300 MHz for 1 H) to 14.1 T (600 MHz for 1 H). Researchers can acquire both routine one-dimensional as well as sophisticated two-dimensional NMR experiments. Facility users have access to all spectrometers and are trained to be self-sufficient users. However, the NMR staff is available for assistance should issues arise while operating the instrument or if researchers would like to discuss specific NMR questions related to their research.
Learn more about the Small Molecule NMR Core.
Antibody and Protein Resource Core
The Vanderbilt Antibody and Protein Resource Core (VAPR) is a university research facility that operates under the auspices of the Vanderbilt Institute of Chemical Biology. VAPR personnel are experienced in the design, development and analysis of a wide range of cell-based reporter and immunological assays used to identify, isolate, and characterize monoclonal antibodies.
Learn more about the Antibody and Protein Resource Core
High-Throughput Screening Core
The High-Throughput Screening Facility utilizes state-of-the art lab automation for sample storage, retrieval, and liquid handling and high-throughput plate readers, data management and analysis software to screen and interrogate chemical libraries (150,000 compounds selected to represent the chemical diversity of more than 1,000,000 MRSF accessible compounds) and recombinant phage-displayed antibody libraries (~ 2.9 x 109 members) to identify reagents for use in research, diagnostic or therapeutic applications.
Learn more about the High-Throughput Screening Core
Chemical Synthesis Core
The Chemical Synthesis Facility supports the Vanderbilt community in all aspects of medicinal and organic synthesis. This core provides quantities of known or unknown compounds with an emphasis on parallel synthesis of small libraries, HPLC purification and scale-up of synthetic procedures.
Learn more about the Chemical Synthesis Core
VUMC Core Facilities
In addition, the VUMC (Vanderbilt University Medical Center) has a wide variety of research core facilities ranging in size from those that serve small groups of investigators to those that support all VUMC investigators. The above link provides a list of those facilities. Details about user priority, procedures and costs are described on the web pages for each core.
Learn more about the VUMC Core Facilities