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Announcement - AuGUST 6, 2013

Vanderbilt Scientists Discover Potential New Way to Treat Anxiety

Lawrence Marnett, Director of the Vanderbilt Institute of Chemical Biology, and Sachin Patel, M.D., Ph.D., report that chemically modified inhibitors of the COX-2 enzyme relieve anxiety behaviors in mice by activating natural "endocannabinoids" without gastrointestinal side effects.  The discovery could represent a new approach to treating mood and anxiety disorders the researchers conclude in a paper published by the journal Nature Neuroscience.  Clinical trials of some of these potential drugs could begin in the next several years. 

For more information, please click on the following links:

1.  Nature Neuroscience (published article) "Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation," Daniel J Hermanson, Nolan D Hartley, Joyonna Gamble-George, Naoko Brown, Brian C Shonesy, Phillip J Kingsley, Roger J Colbran, Jeffrey Reese, Lawrence J Marnett & Sachin Patel
Nat Neurosci. 2013 Aug 4. doi: 10.1038/nn.3480. [Epub ahead of print]

2.  Science News (news story)

3.  Reserach News @ Vandertbilt (news story)

4.  PubMed (abstract database)

5.  Channel 4 News (video)

6.  The Tennessean (news story)






Larry Marnett, Sachin Patel

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