Chemical Synthesis Core
The Chemical Synthesis Core was established within the Vanderbilt Institute of Chemical Biology with the goal of supporting the organic and medicinal chemistry needs of Vanderbilt investigators. The primary focus of the core is to facilitate biology-orientated projects within the medical center and the university by assisting with the chemistry aspect of the project. The core works independently or in collaboration with the VICB High Throughput Screening Center on the synthesis of literature-cited compounds (including patented ones) as well as full scale lead optimization of a compound.
The Chemical Synthesis Core collaborates with Vanderbilt PI's on milligram to multigram synthesis of both single compounds and/or a library of drug like targets. Examples of projects include:
- Synthesis of literature-cited compounds (including patented compounds)
- Medicinal chemistry projects and SAR analysis
- Large scale synthesis of intermediates
Another major responsibility of the core is to support the High Throughput Screening facility in providing synthetic standards, SAR analysis and lead identification follow-up. This involves Vanderbilt investigators as well as the Molecular Libraries Screening Centers Network (MLSCN). The synthesis core group has chemists from varying synthetic backgrounds, including natural product, amino acid and medicinal chemistry. We are also available for advice on chemical synthesis problems. One complimentary service that we provide is assistance in compound acquisition. A number of databases are available to us for searching vendor catalogues (about 14 million compounds). They are much more comprehensive than Scifinder and searching using Google.
Padma Portonovo—Office Manager
Phone: 615-322-8700
Email: padma.s.portonovo@vanderbilt.edu
Website: vanderbilt.edu/syncore/
