Featured Researcher

Albert B. Reynolds, Ph.D.

Dr. Reynolds received his B.A. from Kenyon College and his Ph.D. from the University of Virginia. After research positions with the University of Virginia and St. Jude Children’s Research Hospital, he joined Vanderbilt in 1996.

As a postdoctoral fellow, Dr. Reynolds drove discovery of the major Src substrates, key regulators of motility and adhesion. He generated specific monoclonal antibodies to these proteins and was instrumental in their subsequent identification by cDNA cloning. Recently, he addressed the pathological consequence of p120 downregulation in vivo. His laboratory generated conditional-null p120 mice and examined the consequence of p120 ablation in the salivary glands. The phenotype supports his hypothesis that p120 is a tumor suppressor.

Dr. Reynolds has single-handedly identified an essential regulator of cell adhesion and cell motility, determined its molecular mechanism(s), and demonstrated a critical role for p120 function in maintaining physiologic integrity by establishing that loss of p120 can initiate and/or promote tumor progression.

• PubMed Listing of Dr. Reynolds’ Publications