The Vanderbilt Screening Center for GPCRs, Ion Channels, and Transporters was established as a member of the Molecular Libraries Screening Centers Network (MLSCN) initiated and supported by the National Institutes of Health (NIH) Molecular Libraries Roadmap.

The MLSCN is a nationwide consortium of facilities that provides high-throughput small molecule screening, instrumentation, and expertise to the public research community. The MLSCN also maintains a central repository of more than 100,000 diverse chemical compounds from which chemical libraries are generated.  

Through this unique mechanism, researchers can identify small molecule compounds to be used as tools for exploring the functions of genes and pathways in health and disease at the molecular, cellular and in vivo levels. Screening data generated by the MLSCN is deposited in a public database called PubChem which also provides cheminformatics data mining tools.