Vanderbilt Magazine
Tumors May Have Fueled Hatfield-McCoy Feud
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Winnter Reynolds may have within her body a clue to the legendary Hatfield- McCoy feud. The 11-year-old is a descendant of McCoys who harken from West Virginia and are, according to her grandmother, Goldie, kin to the family known for its long-running clash with the Hatfield family.
Winnter came to the Monroe Carell Jr. Children’s Hospital at Vanderbilt because of a tumor on her adrenal gland. Her grand-aunt and guardian, Rita Reynolds, had similar tumors removed at Vanderbilt a couple of years ago.Winnter’s family has a theory about a connection between these tumors, which run in their family, and the famous feud carried on by their forebears.
“These tumors can send your moods up and down,” Rita Reynolds says. “They diagnosed Winnter with attention deficit disorder, but I think it’s the adrenal tumor that’s been making her hyperactive at times.”
Winnter’s doctors say the theory that a genetic predisposition for adrenal tumors–caused by a genetic disorder called von Hippel-Lindau disease, which Winnter’s family carries–is a possible explanation for why the feuding McCoy family members were so violent and angry.
“Adrenal tumors cause the release of massive amounts of catecholamines–chemicals like adrenalin,” says Dr.Wallace “Skip”Neblett,MD’71, chair of the Department of Pediatric Surgery at Children’s Hospital and Winnter’s surgeon.
The Hatfield and McCoy feud took place in the mountain terrain of Eastern Kentucky and West Virginia.While some say it started over a pig, historians maintain it began when Southern-sympathizing Hatfields murdered a McCoy who had served in the Union Army.
That led to the first of many retaliations. In 1878 “Old Randall” McCoy thought he spotted one of his pigs being stolen by Hatfields. An ensuing string of accusations, botched trials and killings took place until the climactic burning of Old Randall’s home and the murder of his son and daughter in 1888.
Before it was all over, 13 members of the families died violent deaths. There was no further violence after the deaths of the two clan leaders,Old Randall McCoy and Devil Anse Hatfield, in 1914 and 1921, respectively.
In 2002 a symbolic peace treaty was signed by Hatfield and McCoy descendants. Members ofWinnter Reynolds’ family have attended Hatfield-McCoy reunions for years and have been swapping stories about their distant cousins all their lives.
“The theory is, maybe those early McCoys had these adrenal tumors as well and that’s what helped to set them off,” says Winnter’s uncle, Frank Hankins.
“From the scientific point of view, the genetic condition the McCoy family has, von Hippel- Lindau disease, is associated with too much adrenaline and related compounds because of a condition called pheochromocytoma, a type of tumor of the adrenal gland,” says Dr. Revi Mathew, associate professor of pediatrics and Winnter’s endocrinologist.
“It does produce hypertension, headache and sweating intermittently depending on when the surge of these compounds occurs in the bloodstream. I suppose these compounds could possibly make somebody very angry and upset for no good reason.”
Last spring Winnter underwent surgery to remove a tumorous adrenal gland. Because von Hippel-Lindau can cause tumors in several organs during the span of a person’s life, it could be the first of many surgeries.
For more research stories, visit Vanderbilt’s online research news channel, Research News @ Vanderbilt.
© 2012 Vanderbilt University
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Marlene Cochran says:
My grandmother was from the McCoy clan. I am 68 yrs. old and grew up near the K.Y. border where the fight took place. In 1963 I had a tumor removed as well as the adrenal gland. Until reading this, did not know anything about the McCoy decendants having tumors.. It almost killed me before finding out what my problem was. Surger at Duke. They had only seen 13 cases there. If you need any more information regarding this please feel free to email me. I am informing my relatives of this McCoy curse. Marlene Cochran
March 16th, 2009 at 10:24 pmElizabeth Meggs Browning, MA’54 (Nashville) says:
Imagine my surprise when I turned to page 24 of the Fall 2007 issue to see a picture of my husband’s grandmother and great-grandfather.
My husband, U. Grant Browning, MDiv’58, is the grandson of Betty Hatfield Caldwell and the great-grandson of [Hatfield clan patriarch] William Anderson “Devil Anse” Hatfield. Our daughter, Barbara Browning, BA’78, is the great-great-granddaughter of “Devil Anse.” The feud is an interesting part of our family history, but I never expected to see a connection to Vanderbilt.
March 19th, 2009 at 10:47 amThank you for an informative article.
maryjane howes kimball says:
Devil Anse Hatfield is my grand grand grandfather I was name after my great grandmother Mary Jane Hatfield Howes. My dad was
March 26th, 2009 at 11:19 pmJohn E. Howes and he was from Sarah Ann, W.Va.
Nichole McRoberts says:
My grandfather told me last summer that we are related to the hatfields and the mcCoys and reading about the tumors and it gave me chills. I have all of those symptoms,feels like i’m going to pass out sometimes. I get angry for know real reason. Now i see my 6yr old showing the signs. I will be checking on that.
May 29th, 2010 at 4:17 pmSally Decker says:
As far as I know I’m not a relative of the McCoys, or Hatfields for that matter, however, I too have had this tumor. I had it for 10 years with no doctor in Indiana finding the problem but blaming all kinds of other things, including saying it as all in my head. When I moved to Florida in 2005 I was in the hosptial dying when they found the tumor and then later removed it at Shands Hospital. The doc. that had found it had only seen it once before and that person died. However, I never know when it will return and now knowing the symptoms I’m sure that my father and grandfather also had this tumor and no one found them in those days. Good luck to all who have it, it changes your personality and life completely. I’m now a diabetic because of this tumor.
December 13th, 2010 at 11:39 amKaren says:
Note: genetic testing for VHL is available at the request of your doctor (testing cost $313) via the Molecular Genetics Laboratory at the Children’s Hospital of Philadelphia (formerly the Genetic Diagnostic Laboratory at the University of Pennsylvania School of Medicine):
http://www.vhl.org/press/mccdna.php
May 27th, 2011 at 11:36 amRegina M. Terry says:
My father, Charley Franklin McCoy died of adrenal glad cancer. We have common ancestry with the feuding McCoys. If you are a McCoy descendent, it does not hurt to allert your family physician about the possibility of you having this disorder.
June 3rd, 2011 at 6:50 pm