News: HDAC

Leukemia’s Chromosomal Break-ups

Friday, June 29th, 2012

Scott Hiebert, Ph.D., has been on a 20-year hunt for the causes of acute myeloid leukemia (AML). When he entered the field in 1992, scientists had identified multiple chromosomal translocations – where two chromosomes break apart and exchange some genetic information – in cells from patients with acute leukemia. At the junctions (breakpoints) where the [...]

DNA Mechanics

Wednesday, December 8th, 2010

Picture a railroad track, running across the countryside. DNA looks something like that track. Its “rails” are chains of chemicals called nucleotides, each pairing with a partner on the opposite chain to form the “ties.” To ensure timely train traffic – and prevent catastrophic derailments – the railroad track needs regular maintenance. So does DNA. [...]