The Role of Tissue Anisotropy in the Generation of the MCGA Progress Report

Table of Contents

The Role of Tissue Anisotropy in the Generation of the MCGA Progress Report

Outline

The Difficulty with the Magnetocardiogram

Magnetically Silent Sources

Getting closer ...

Langendorff perfused Isolated Rabbit Heart

Getting Smaller ...

Pickup Coil

Cryostat Design

SQUID Microscope - Scanning Stage

Field Sensitivity

Magnetically Shielded Room

Langendorff perfused Isolated Rabbit Heart

Langendorff perfused Isolated Rabbit Heart

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Simplify the Problem ...

MCG As a Function of Position

Cathodal Current Injection

Initiation of Action Currents

Propagation of Action Currents

Cardiac Bidomain

BioDomain – Equations - Current Injection

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Propagation of Action Currents

Cardiac Bidomain - 2 Dimensional Model

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Action Potential Propagation

Circular Action Potential

Can we extract Data?

Experimental Setup

Experimental Setup - Optical Imaging

S2- Point Stimulation

Isochrones - left ventricular free wall

Now - Add some Twist

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Isochrones - Stimulation at Apex

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Dipole Signature in St-segment

T-wave - Repolarization

Questions