The Role of Anisotropy on the Initiation and Propagation of Action Currents in Cardiac Tissue A Progress Report

Table of Contents

The Role of Anisotropy on the Initiation and Propagation of Action Currents in Cardiac Tissue: A Progress Report

Outline

The Difficulty with the Magnetocardiogram

Magnetically Silent Sources

Getting closer ...

Langendorff perfused Isolated Rabbit Heart

Getting Smaller ...

Pickup Coil

Retractable Pickup Coil

Field Sensitivity

Langendorff perfused Isolated Rabbit Heart

SQUID

Langendorff perfused Isolated Rabbit Heart

Rabbit Heart / SQUID set up

Simplify the Problem ...

MCG As a Function of Position

Cathodal Current Injection

Initiation of Action Currents

Cardiac Bidomain

Bidomain – Equations - Current Injection

Layered Bidomain Model / Experiment

Bidomain Illustration

Can we extract Model Parameter?

Experimental Setup

Experimental Setup - Optical Imaging

S2- Point Stimulation

Propagation of Action Currents

Isochrones - left ventricular free wall

Now - Add some Twist

Isochrones - left ventricular free wall

Velocities as a function of direction

Now - Add some Twist

Slide

Access Spatial Gradients

Gradients in Repolarization

Slide

Questions