Current Injection into Two-Dimensional Anisotropic Bidomain
Sepulveda, N.G., Roth, B.J., Wikswo, J.P. Jr.;
Biophysical Journal, Vol 55 (5), pp 987-999, 1989
A two-dimensional sheet of anisotropic cardiac tissue is represented with the bidomain model, and the finite element method is used to solve the bidomain equations. When the anisotropy ratios of the intracellular and extracellular spaces are not equal, the injection of current into the tissue induces a transmembrane potential that has a complicated spatial dependence, including adjacent regions of depolarized and hyperpolarized tissue. This behavior may have important implications for the electrical stimulation of cardiac tissue and for defibrillation.
The following reprint from Biophysical Journal, Volume 55 (5) , Sepulveda, N.G., Roth, B.J., Wikswo, J.P. Jr. "Current Injection into Two-Dimensional Anisotropic Bidomain", 987-999, Copyright 1989 is made available by permission of the publisher Biophysical Society.
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