The Drug-Independent Roles of Cardiac Geometry and Tissue Anisotropy in Defibrillation and Reentry
There is more to reentry and defibrillation than just channel effects ….
Antiarrhythmic drugs are not the entire story….
The rest of the story….
Possible explanations for the ability of strong stimuli to defibrillate the heart
Approach
Methods: Perfusion
Optical Imaging Setup
Methods: Imaging
Methods: Pacing
Gus2 MatLab Data Viewing Program Gustavo Rohde
Tissue Response to Field Shock
Faster Response with Increasing Shock Strength
Methods: Image Processing
Q(t), px(t), py(t) for S1 and +/- 27 V/cm S2
How fast is the heart being activated by S1 and S2?
Activation Times
Activation Time versus S2 Field Strength
Transmural Imaging of Endocardial Activation
Endocardial versus Epicardial Activation Times
Summary