The Drug-Independent Roles of Cardiac Geometry and Tissue Anisotropy in Defibrillation and Reentry

Table of Contents

The Drug-Independent Roles of Cardiac Geometry and Tissue Anisotropy in Defibrillation and Reentry

There is more to reentry and defibrillation than just channel effects ….

Antiarrhythmic drugs are not the entire story….

The rest of the story….

Possible explanations for the ability of strong stimuli to defibrillate the heart

Approach

Methods: Perfusion

Optical Imaging Setup

Methods: Imaging

Methods: Pacing

Gus2 MatLabData Viewing ProgramGustavo Rohde

Tissue Response to Field Shock

Faster Response with Increasing Shock Strength

Methods: Image Processing

Q(t), px(t), py(t) for S1 and +/- 27 V/cm S2

How fast is the heart being activated by S1 and S2?

Activation Times

Activation Time versus S2 Field Strength

Transmural Imaging of Endocardial Activation

Endocardial versus Epicardial Activation Times

Summary