High Resolution Magnetocardiogram (MCG) Imaging of Action Currents in Cardiac Tissue

Table of Contents

High Resolution Magnetocardiogram (MCG) Imaging of Action Currents in Cardiac Tissue

Superconducting Quantum Interference Devises (SQUIDs), are the most sensitive magnetic field sensor, to image magnetic fields generated by bioelectric currents, magnetic susceptibility and remanant magnetizationswith a sensitivity ten orders of magnitude smaller than the earth’s magnetic field.

Squids Are Flux to Voltage Converters

Cryostat Design

Pickup Coil

SQUID Microscope - Scanning Stage

Field Sensitivity

Experimental Setup

Langendorff perfused Isolated Rabbit Heart

Langendorff perfused Isolated Rabbit Heart

Langendorff perfused Isolated Rabbit Heart

MCG As a Function of Position

Cathodal Current Injection

Initiation of Action Currents

Propagation of Action Currents

Cardiac Bidomain

BioDomain – Equations

BioDomain – Current Injection

BioDomain – Current Injection

Action Potential Propagation

Circular Action Potential

Propagation of Action Currents

The Cardiac Bidomain Model

Dipol Signature in St-segment

T-wave - Repolarization

Conclusions

Vanderbilt Living State Physics