Publications

Select publications from Ethan Lee (complete list):

Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E. The way Wnt works: Components and mechanism. Growth Factors 2012 Dec

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs. Bioorganic & Medicinal Chemistry. 2012 Mar 15;20(6):1869–77.

Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. XIAP Monoubiquitylates Groucho/TLE to Promote Canonical Wnt Signaling. Molecular Cell. 2012 Mar 9;45(5):619–28.

Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts. J Biomol Screen 2011 Oct;16(9):995–1006.

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, Lafleur B, Salic A, Lee LA, Miller DM 3rd, Lee E. Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Nat Chem Biol. 2010

Jernigan, KK, Cselenyi, CS, Thorne, CA, Hanson, AJ, Tahinci, E, Hajicek, N, Oldham, WM, Lee, LA, Hamm, HE, Hepler, JR, Kozasa, T, Linder, ME, Lee, E. Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci Signal, 3(121), ra37, 2010

Barton, CE, Tahinci, E, Barbieri, CE, Johnson, KN, Hanson, AJ, Jernigan, KK, Chen, TW, Lee, E, Pietenpol, JA. DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis. Dev Biol, 329(1), 130-9, 2009

Cselenyi, CS, Jernigan, KK, Tahinci, E, Thorne, CA, Lee, LA, Lee, E. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3′’s phosphorylation of {beta}-catenin. Proc Natl Acad Sci U S A, , , 2008

Cselenyi, CS, Lee, E. Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen. Sci Signal, 1(8), pe10, 2008

Lee, Laura A, Lee, Ethan, Anderson, Michael A, Vardy, Leah, Tahinci, Emilios, Ali, Siraj M, Kashevsky, Helena, Benasutti, Matt, Kirschner, Marc W, Orr-Weaver, Terry L. Drosophila Genome-Scale Screen for PAN GU Kinase Substrates Identifies Mat89Bb as a Cell Cycle Regulator. Dev Cell, 8(3), 435-42, 2005.