The Nesprin-Cytoskeleton Interface Probed Directly on Single Nuclei is a Mechanically Rich System
Daniel A. Balikov, Sonia K. Brady, Ung Hyun Ko, Jennifer H. Shin, Jose M. de Pereda , Arnoud Sonnenberg , Hak-Joon Sung & Matthew J. Lang
(2017) Nucleus PDF

Rational Development of Near-Infrared Fluorophores with Large Stokes Shifts, Bright One-Photon, and Two-Photon Emissions for Bioimaging and Biosensing Applications
Liyi Zhou, Qianqian Wang, Yi Tan, Matthew J. Lang, Hongyan Sun and Xiaogang Liu
(2017) Chem. Eur. J. PDF

Modulating aggregation-induced emission via a non-conjugated linkage of fluorophores to tetraphenylethenes
Xie Han, Bibo Zhang, Jianhua Chen, Sheng Hua Liu, Chunyan Tan, Haiyang Liu, Matthew J. Lang, Ying Tan, Xiaogang Liu and Jun Yin
(2017) J. Mater. Chem. B PDF

Mechanically Watching the ClpXP Proteolytic Machinery
Juan Carlos Cordova, Adrian O. Olivares, and Matthew J. Lang
(2017) Arne Gennerich (ed.), Optical Tweezers: Methods and Protocols, Methods in Molecular Biology PDF

Pre-TCRs leverage Vβ CDRs and hydrophobic patch in mechanosensing thymic self-ligands
Dibyendu Kumar Das, Robert J. Mallis, Jonathan S. Duke-Cohan, Rebecca E. Hussey, Paul W. Tetteh, Mark Hilton, Gerhard Wagner, Matthew J. Lang and Ellis L. Reinherz
(2016) JBC PDF

Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability through effectively inhibiting twisted intramolecular charge transfer
Xiaogang Liu, Qinglong Qiao, Wenming Tian, Wenjuan Liu, Jie Chen, Matthew J. Lang, Zhaochao Xu
(2016) Journal of American Chemical Society PDF

Cellobiohydrolase 1 from Trichoderma reesei degrades cellulose in single cellobiose steps
Sonia K. Brady, Sarangapani Sreelatha, Yinnian Feng, Shishir P.S. Chundawat & Matthew J. Lang
(2015) Nat. Commun. PDF

Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination
Kristine N. Brazin, Robert J. Mallis, Dibyendu K. Das, Yinnian Feng, Wonmuk Hwang, Jia-huai Wang1, Gerhard Wagner, Matthew J. Lang and Ellis L. Reinherz
(2015) Front. Immunol. PDF

Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8
Yongdae Shin, Yaqing Du, Scott E. Collier, Melanie D. Ohi, Matthew J. Lang, and Ryoma Ohi
(2015) PNAS PDF

Single-Particle Spectroscopic Study on Fluorescence Enhancement by Plasmon Coupled Gold Nanorod Dimers Assembled on DNA Origami.
Taishi Zhang, Nengyue Gao, Shuang Li, Matthew J. Lang and Qing-Hua Xu
(2015) J. Phys. Chem. Lett. PDF

A force-dependent transition in the T cell receptor β subunit allosterically regulates peptide discrimination and pMHC bond lifetime.
Dibyendu Kumar Das, Yinnian Feng, Robert J Mallis, Xiaolong Li, Derin B. Keskin, Rebecca E. Hussey, Sonia K. Brady, Jia-Huai Wang, Gerhard Wagner, Ellis L Reinherz and Matthew J. Lang.
(2015) PNAS PDF

Research and education at the crossroads of biology and physics.
Mel Sabella and Matthew J. Lang.
(2014) American Journal of Physics 82 365. PDF

Combining Single-Molecule Manipulation and Single-Molecule Detection.
Juan Carlos Cordova, Dibyendu Kumar Das, Harris W. Manning and Matthew J. Lang.
(2014) Current Opinion in Structural Biology 28 142-148. PDF

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine.
Juan Carlos Cordova, Adrian O. Olivares, Yongdae Shin, Benjamin M. Stinson, Stephane Calmat, Karl R. Schmitz, Marie-Eve Aubin-Tam, Tania A. Baker, Matthew J. Lang and Robert T. Sauer.
(2014) Cell 158 647-658. PDF

Kinesin-12 Kif15 targets kinetochore-fibers via an intrinsic two-step mechanism.
Emma G. Sturgill, Dibyendu Kumar Das, Yoshimasa Takizawa, Yongdae Shin, Scott Collier, Melanie D. Ohi, Wonmuk Hwang, Matthew J. Lang, Ryoma Ohi.
(2014) Current Biology 24 2307-2313. PDF

Modular Aspects of Kinesin Force Generation Machinery.
William R. Hesse, Miriam Steiner, Matthew L. Wohlever, Roger D. Kamm, Wonmuk Hwang and Matthew J. Lang.
(2012) Biophysical Journal 104 1-10. PDF

TCR mechanobiology: torques and tunable structures linked to early T cell signaling.
Sun Taek Kim, Yongdae Shin, Kristine Brazin, Robert J. Mallis, Zhen-Yu J. Sun, Gerhard Wagner, Matthew J. Lang and Ellis L. Reinherz.
(2012) Frontiers in Immunology 3 1-8. PDF

Stochastic optical active rheology.
Hyungsuk Lee, Yongdae Shin, Sun Taek Kim, Ellis L. Reinherz and Matthew J. Lang.
(2012) Applied Physics Letters 101 031902. PDF

Maximal Force Characteristics of the Ca2+-Powered Actuator of Vorticella convallaria.
Sangjin Ryu, Matthew J. Lang and Paul Matsudaira.
(2012) Biophysical Journal 103 860-867. PDF

Nucleotide-dependent control of internal strains in ring-shaped AAA+ motors.
Hwang, W. and Lang, M.
(2012) Cellular and Molecular Bioengineering 1-9. PDF

Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine.
Marie-Eve Aubin-Tam, Adrian O. Olivares, Robert T. Sauer, Tania A. Baker and Matthew J. Lang.
(2011) Cell 145 257-267. PDF

Physical Properties of Polymorphic Yeast Prion Amyloid Fibers.
Carlos E. Castro, Jijun Dong, Mary C. Boyce, Susan Lindquist and Matthew J. Lang.
(2011) Biophysical Journal 101 439-448. PDF

A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment.
Peyman Honarmandi, Hyungsuk Lee, Matthew J. Lang and Roger D. Kamm.
(2011) Lab Chip 11 684-694. PDF

Quantification of Urinary Stone Volume: Attenuation Threshold-based CT Method-A Technical Note.
Shadpour Demehri, Mannudeep K. Kalra, Frank J. Rybicki, Michael L. Steigner, Matthew J. Lang, E. Andres Houseman, Gary C. Curhan, Stuart G. Silverman.
(2011) Radiology 258 915-922. PDF

Optical trapping with high forces reveals unexpected behaviors of prion fibrils.
Jijun Dong, Carlos E. Castro, Mary C. Boyce, Matthew J. Lang, and Susan Lindquist
(2010) Nature Structural & Molecular Biology 17 1422-1430. PDF

Control and Manipulation of Pathogens with an Optical Trap for Live Cell Imaging of Intercellular Interactions.
Jenny M. Tam, Carlos E. Castro, Robert J. W. Heath, Michael L. Cardenas, Ramnik J. Xavier, Matthew J. Lang, Jatin M. Vyas
(2010) PLoS ONE 5 e15215.

Go forth and measure.
Matthew J. Lang
(2010) APS Forum on Education Fall 2010 Newsletter p32.

Adhesion through single peptide aptamers.
Marie-Eve Aubin-Tam, David C. Appleyard, Enrico Ferrari, Valeria Garbin, Oluwatimilehin O. Fadiran, Jacquelyn Kunkel and Matthew J. Lang
(2010) Journal of Physical Chemistry A. xxxx xxx. PDF

Motor Proteins: Kinesin Drives with an Underhead Cam.
Matthew J. Lang, and Wonmuk Hwang
(2010) Current Biology 20 R408-R410. PDF

Molecular origin of strain softening in cross-linked F-actin networks.
Hyungsuk Lee, Jorge M. Ferrer, Matthew J. Lang, and Roger D. Kamm
(2010) Physical Review E 82 011919. PDF

Passive and active microrheology for cross-linked F-actin networks in vitro.
Hyungsuk Lee, Jorge M. Ferrer, Fumi Nakamura, Matthew J. Lang, and Roger D. Kamm
(2010) Acta Biomaterialia 6: 1207-1218. PDF

Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease.
Yongdae Shin, Joseph H. Davis, Ricardo R. Brau, Andreas Martin, Jon A. Kenniston, Tania A. Baker, Robert T. Sauer, and Matthew J. Lang.
(2009) PNAS 106: 19340-19345. PDF

The aB T Cell Receptor is an Anisotropic Mechanosensor.
Sun Taek Kim, Koh Takeuchi, Zhen-Yu J. Sun, Maki Touma, Carlos E. Castro, Amr Fahmy, Matthew J. Lang, Gerhard Wagner and Ellis L. Reinherz.
(2009) Journal of Biological Chemistry 284:31028-31037. PDF

Mechanical Design of Translocating Motor Proteins.
Wonmuk Hwang and Matthew J. Lang
(2009) Cell Biochemistry and Biophysics 54: 11-22. PDF

IOFF Generally Extends Fluorophore Longevity in the Presence of an Optical Trap.
Jorge M. Ferrer, Ding Fangyuan, Ricardo R. Brau, Peter B. Tarsa and Matthew J. Lang.
(2009) Current Pharmaceutical Biotechnology 10: 502-507. PDF

Functional Measurement of Biological Parts.
Matthew J. Lang and David C. Appleyard.
(2009) Conference on Lasers and Electro-Optics (CLEO) 2009 paper. CTuU1. PDF

Cytoskeletal Deformation at High Strains and the Role of Cross-link Unfolding or Unbinding.
Hyungsuk Lee, Benjamin Pelz, Jorge M. Ferrer, Taeyoon Kim, Matthew J. Lang and Roger D. Kamm.
(2009) Cellular and Molecular Bioengineering 2: 28-38. PDF

Kinesin's cover-neck bundle folds forward to generate force.
Ahmad S. Khalil, David C. Appleyard, Anna K. Labno, Adrien Georges, Martin Karplus, Angela M. Belcher, Wonmuk Hwang and Matthew J. Lang.
(2008) PNAS 105: 19246-19251. PDF

Measuring molecular rupture forces between single actin filaments and actin-binding proteins.
Jorge M. Ferrer, Hyungsuk Lee, Jiong Chen, Benjamin Pelz, Fumihiko Nakamura, Roger D. Kamm and Matthew J. Lang.
(2008) PNAS 105: 9221-9226. PDF

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation.
Wonmuk Hwang, Matthew J. Lang and Martin Karplus.
(2008) Structure 16: 62-71. PDF  Link

Single M13 bacteriophage tethering and stretching (Cover Article). 
Khalil, A.S., Ferrer, J.M., Brau, R.R., Kottmann, S.T., Noren, C.J., Lang, M.J., Belcher, A.M. 
(2007) PNAS 104: 4892-4897.  PDF

Detecting Force-Induced Molecular Transitions with Florescence Resonant Energy Transfer. 
Tarsa, P.B., Brau, R.R., Barch, M., Ferrer, J.M., Freyzon, Y., Matsudaira, P., Lang, M.J.
(2007) Angewandte Chemie, International Edition 46(12): 1999-2001.  Link PDF

Active particle control through silicon using conventional optical trapping techniques.
Appleyard, D.C., and Lang, M.J.
(2007) Lab on a Chip 7: 1837-1840. Link

Geometric Confinement Influences Cellular Mechanical Properties II -Intracellular Variances in Polarized Cells.
Su, J., Brau, R.R., Jiang, X., Whitesides, G.M., Lang, M.J., So, P.T.C.
(2007) Molecular & Cellular Biomechanics. 4 (2): 105-118. PDF

Passive and active microrheology with optical tweezers. 
Brau, R.R., Ferrer, J.M., Lee, H.S., Castro, C.E., Tam, B.K., Tarsa, P.B., Matsudaira, P., Boyce, M.C., Kamm, R.D., Lang, M.J.
(2007) Journal of Optics A: Pure and Applied Optics 9 (2007) S103-S112. Link

Lighting up the Mechanome.
Lang, M.J.
(2007) The Bridge. 37 (4): 11-16. PDF

Effect of plasmodial RESA protein on deformability of human red blood cells harboring Plasmodium falciparum. 
J.P. Mills, M. Diez-Silva, D.J. Quinn, M. Dao, M.J. Lang, K.S.W. Tan, C.T. Lim, G. Milon, P.H. David, O. Mercereau-Puijalon, S. Bonnefoy, S. Suresh. PNAS 104, 22
(2007) 9213-9217. PDF

Force of an Actin Spring.
Shin, J.H., Tam, B.K., Brau, R.R., Lang, M.J., Mahadevan, L., Matsudaira, P.
(2007) Biophysical Journal. 92: 3729-3733. PDF

Optical Trapping for Undergraduates. 
Appleyard, D.C., Vandermeulen, K., Lee, H., Lang, M.J. 
(2007) American Journal of Physics. 75(1): 5-14.  PDF

Interlaced optical force-fluorescence measurements for single molecule biophysics. 
Brau, R.R., Tarsa, P.B., Ferrer, J.M., Lee, P., Lang, M.J.
(2006) Biophysical Journal 91(3): 1069-1077.  PDF

Unbinding Simulation of Kinesin's Neck Linker. 
Wonmuk Hwang, Matthew J. Lang and Martin Karplus.
(2006) Proceedings of the IASTED International Conference COMPUTATIONAL AND SYSTEMS BIOLOGY 540-009 73-76.  PDF

Simultaneous, coincident optical trapping and single-molecule fluorescence.
Lang, M.J., Fordyce, P.M., Engh, A.M., Neuman, K.C., Block, S.M.
(2004) Nature Methods 1(2): 133-139.  PDF

Combined optical trapping and single-molecule fluorescence.
Lang, M.J., Fordyce, P.M., and Block, S.M.
(2003) Journal of Biology 2(1): 6. PDF

Probing the kinesin reaction cycle with a 2D optical force clamp.
Block, S.M., Asbury, C.L., Shaevitz, J.W., and Lang, M.J.
(2003) PNAS 100(5): 2351. PDF

LBOT-1: Laser-based optical tweezers.
Lang, M.J., and Block, S.M.
(2003) American Journal of Physics 71(3): 201. PDF

An Automated Two-Dimensional Optical Force Clamp for Single Molecule Studies.
Lang, M.J., Asbury, C.L., Shaevitz, J.W., and Block, S.M.
(2002). Biophysical Journal 83(1): 491. PDF

Aqueous Solvation Dynamics Studied by Photon Echo Spectroscopy.
M.J. Lang, X. J. Jordanides, X. Song and G. R. Fleming. 
(1999) Journal of Chemical Physics 110(12): 5884.  PDF

Solvation Dynamics in Protein Environments Studied by Photon Echo Spectroscopy.
X. J. Jordanides, M. J. Lang, X. Song and G. R. Fleming. 
(1999) Journal of Physical Chemistry B 103(37): 7995. PDF

Photoinduced electron transfers through sigma bonds in solution.
N.C.C. Yang, S.L. Zhang, M.J. Lang, S. Goodman, C. Durnell, G.R. Fleming, H.L. Carrell, R.M. Garavito. 
(1999) in Electron Transfer - From Isolated Molecules to Biomolecules, Part 1: 645.

The intermolecular interaction mechanisms in liquid CS2 at 299 K and 164 K probed with two-dimensional Raman spectroscopy. 
A. Tokmakoff, M.J. Lang, X.S. Jordanides and G.R. Fleming. 
(1998) Chemical Physics 233(2-3): 231.  PDF

Two-Dimensional Raman Spectroscopy of Vibrational Interactions in Liquids.
A. Tokmakoff, M.J. Lang, D.S. Larsen, G.R. Fleming, V. Chernyak and S. Mukamel 
(1997) Physical Review Letters 79(14): 2702. PDF

Intrinsic Optical Heterodyne Detection of a Two-Dimensional Fifth Order Raman Response.
A. Tokmakoff, M. J. Lang, D.S. Larsen and G.R. Fleming. 
(1997) Chemical Physics Letters 272(1-2): 48. PDF

Direct Measurement of Intrinsic Proton Transfer Rates in Diffusion Controlled Reactions. 
E. Pines, B-Z. Magnes, M.J. Lang and G.R. Fleming. 
(1997) Chemical Physics Letters 281(4-6): 413. PDF

Pump-Probe Polarization Anisotropy Study of Femtosecond Energy Transfer within the Photosynthetic Reaction Center of Rhodobacter sphaeroides R26.
D.M. Jonas, M.J. Lang, Y. Nagasawa, T. Joo and G.R. Fleming.
(1996) Journal of Physical Chemistry 100(30): 12660. PDF

Third-Order Nonlinear Time Domain Probes of Solvation Dynamics. 
T. Joo, Y. Jia, J-Y. Yu, M.J. Lang and G.R. Fleming.
(1996) Journal of Chemical Physics 104(16): 6089. PDF

Energy Transfer in the Photosynthetic Reaction Center. 
D.M. Jonas, M.J. Lang, Y. Nagasawa, and G.R. Fleming.
(1996) in Ultrafast Phenomena X,62, Springer, p. 336.

Donor-Acceptor Interaction and Photochemistry of Polymethylene-linked Bichromophores in Solution.
S-L. Zhang, M.J. Lang, S. Goodman, C. Durnell, V. Fidler, G.R. Fleming, and N.-C. Yang. 
(1996) Journal of the American Chemical Society 118(38): 9042. PDF

Energy Transfer and Trapping in Photosystem I Reaction Centers from Cyanobacteria.
L. DiMagno, C-K. Chan, Y. Jia, M.J. Lang, J. R. Newman, L. Mets, G.R. Fleming and R. Haselkorn. 
(1995) PNAS 92(7): 2715. PDF

Observation of Ultrafast Energy Transfer from the Accessory Bacteriochlorophylls to the Special Pair in Photosynthetic Reaction Centers.
Y. Jia, D.M. Jonas, T. Joo, Y. Nagasawa, M.J. Lang and G.R. Fleming.
(1995) Journal of Physical Chemistry 99(17): 6263. PDF

Ultrafast Energy Transfer within the Bacterial Photosynthetic Reaction Center.
D.M. Jonas, M.J. Lang, Y. Nagasawa, S.E. Bradforth, S.N. Dikshit, R. Jimenez, T. Joo and G.R. Fleming.
(1995) Proceedings of the Feldafing III Workshop - Reaction Centers of Photosynthetic Bacteria Structure and Dynamics, Munich, Germany.