| Buckingham, now Buckingham, Browne and Nichols |
| Nobel autobiography |
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| Nauta died in 1994. MIT obituary |
| Results of her thesis were published in Science |
| The branch of physiology that studies the relationship between electric phenomena and bodily processes. |
| The department subsequently changed its name to cell and developmental biology. |
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Casagrande Biosketch
Casagrande had always done well in math and physics, so after she graduated from high school she decided to go into one of these fields. “But I was turned off by east coast snobbery and decided to attend a large, co-educational campus,” she says, As a result, she enrolled at the University of Colorado in Boulder, which she had visited while accompanying her father to a conference. A turning point came in one of her math classes. “I remember looking out the windows at the spectacular view and thinking how boring the course was,” she recalls. Having decided that a career in math was not her cup of tea, she began exploring other options. She took a course in biopsychology, which included classes and lab. “I thought it was very interesting, so I decided to switch majors.”
Returning to Boston, she landed a job as a technician at the management consulting firm Arthur D. Little. Her job involved looking at the effects of the compound methotrexate on the brains of macaque monkeys. After two and a half years, however, she was bored and began looking around for a new job. While she was job hunting, Casagrande interviewed with Nobel Laureate Torston Wiesel One of the courses was on neuroanatomy and was taught by the famous anatomist Walle Nauta.
So Casagrande packed up her VW bug and drove to North Carolina. “I must have been quite a sight when I arrived in Diamond’s office,” she recalls. “My hair was long and I was dressed in an outrageous outfit with a short skirt.” She thinks it was her appearance in part that prompted Diamond to observe at their first meeting that she didn’t have to get a doctorate, adding that his wife didn’t have a Ph.D. and was quite happy. According to Casagrande, “My reaction was, ‘What a strange thing for him to say!’” Although it turned out that Diamond was a bit of a chauvinist - Casagrande was one of only two women who got doctorates under his supervision - she says that he became a good friend and proved to be very supportive.
The hard work paid off. She successfully completed her thesis that dealt with the effects that the superior colliculus [FN: Part of the brain that constitutes a primitive center for vision. Also called optic lobe, optic tectum.] has on the behavior of tree shrews and received her doctorate in 1972 in physiological psychology. After staying at Duke an additional year as a post-doctoral fellow, Casagrande moved north to the University of Wisconsin to study anatomy with Ray Guillery. There she learned electron microscopy and electrophysiology.
Before having children, the couple realized that they would need domestic help and decided that this wasn’t an area where they wanted to cut corners. “If you are trusting your most valuable possessions to someone, you have to pay them a living wage,” she asserts. They hired a fellow church member to prescreen applicants. Although they had specified a person of mature years, the screener persuaded them to talk to a 19-year-old applicant. When they met the young lady, they agreed that she was perfect for the job. So they hired her before their first son, James, was born and she stayed with them for six and a half years. They continued to have hired help until their second son, Paul, finished ninth grade.
In order to keep their relationship strong while their children were small, the couple insisted on having a “date” once a week when they would go out to dinner alone. “When you are raising children, you need time for adult conversation,” she says. The family went on skiing trips every winter and, as the children got older, the couple took them along on trips to scientific conferences when they took place at locations where there were interesting things to keep the boys entertained. Sailing, bicycling, basketball and tennis were other favorite family pastimes. Today, her oldest son has graduated from college with a triple major in computer science, psychology and neuroscience and is working at the Oregon Health Science Center in Portland. Her youngest son is studying engineering at the University of Colorado, Boulder. And McKanna, who retired a year ago, is urging her to consider retiring as well, even though he still does research and publishes papers part time. “I’m still having too much fun to think about retiring,” Casagrande objects, admitting that she is the workaholic in the family. However, she has agreed to begin taking more time off to travel with her husband.
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