Trypterygium Wilfordii II Hook F Extracts as Therapeutic Agents

The present invention provides for the use of Tripterygium wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase-2 induction and inflammatory processes such as the production of prostaglandin E.sub.2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.

Website
U.S. Patent 5,616,458: Tripterygium wilfordii hook F extracts and components, and uses thereof

Inventors: 
William KovacsNancy OlsenPeter LipskyXe-Lien TaoJian Cai
Licensing manager: 
Taylor Jordan

Featured Video

Vanderbilt Patent Activity

View Vanderbilt University Patents

CTTC on Twitter