Tetrameric LERK Promotes Cell Attachment and Cell-Cell Assembly

The present invention provides methods for screening an EphB receptor or an EphB receptor-binding ligand for the ability to promote a selected biological activity when in multimeric form. The invention also provides methods for initiating, promoting, directing, or inhibiting biological activities that involve EphB receptors and/or EphB receptor-binding ligands. The invention further provides compositions that can be used in the foregoing methods.

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U.S. Patent 6,555,321: Methods for determining cell responses through EphB receptors