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A System for Growing Small Populations of Living Cells and Monitoring Their Physiological State
This invention combines the microfluidic and microelectronic devices and techniques required for the microminiaturization of cell culture and cell measurement systems to allow monitoring the response of populations of 1 to several hundred living cells. The instrument(s) allows for the detection of extracellular, membrane, and intracellular parameters; and the incorporation of closed-loop control techniques to continuously monitor the health of the cell and adjust the environmental and pharmacological parameters that control the cell.
Inventors:John Wikswo, Jr.R. Robert BalcarcelFranz BaudenbacherDavid CliffelOwen McGuinnessDavid OstermanTed BaptySven EklundJon GilliganAles ProkopYuansheng YangLindsey ClarkTodd MonroeMark StremlerAndreas Werdich