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Pulsed Infrared Light for the Inhibition of Central Nervous System Neurons
Vanderbilt researchers have developed a novel method for contactless simulation of the central nervous system. This technique involves the use of infrared neural stimulation (INS) to evoke the observable action potentials from neurons of the central nervous system. While infrared neural stimulation of the peripheral nervous system was accomplished almost a decade ago, this is the first technique for infrared stimulation of the central nervous system.
• Electrical field spread in electrical stimulation excites too large of a volume of tissue and cannot provide local excitation.
• Electrical stimulation requires physical contact with tissue
Vanderbilt researchers have pioneered the application of pulsed infrared beams for stimulation of the peripheral nervous system. The present technology extends the appliation of similar stimulation to the central nervous system. Since the observed physiological responses appear to be similar in magnitude to those resulting from tactile stimulation, there exists the promise of eventual application to study functional neural circuitry, including potential application in deep brain stimulation.
Intrinsic signals produced by different rates of INS. (A) Blood vessel map. Location of fiber optic is indicated by arrow. Orange pixels indicate significant pixels in t-test between 100 Hz stimulation and blank condition. (B–E) Activation maps of laser repetition rates: 50 Hz (B), 100 Hz (C), 150 Hz (D), 200 Hz (E). (F) Time course of response resulting from laser stimulation conditions 50 Hz (red), 100 Hz (blue), 150 Hz (yellow), and 200 Hz (aqua blue) and blank conditions. (G) Laser repetition rate vs. the peak amplitude of the intrinsic signal. Scale bar next to (E) indicates clipping range of images (B–E).
• Can modulate intrinsic optical response for individual eye for potential functional stimulation testing
• Provides functional specifications for potential deep brain stimulation application
• Can be engineered to target a specific volume of tissue, due to penetration depth control
• Potential to stimulate a single neuron, due to improved spatial precision
• Contactless stimulation can be minimally invasive
Intellectual Property Status
PCT Application WO2012162523 A1 has been filed: http://www.google.com/patents/wo2012162523a1
Link to research lab website and other publications: http://research.vuse.vanderbilt.edu/bmeoptics/
Inventors:Anita Mahadevan-JansenJonathan CayceRobert FriedmanAnna RoeEric JansenMykyta ChernovPeter Konrad