Peptide and Protein Fragmentation by Lysine Residue Originated Reactions

A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.

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U.S. Patent 7,858,388: MS based peptide and protein sequencing via reactions of lysine residues with peroxycarbonate compounds