Method for Regulation of DNA and RNA Transcription and Translation

Summary

Vanderbilt researchers have discovered and patented a means of selectively expressing genes of interest in specific cells. This research tool allows an inactive nucleic acid to be delivered to a specific cell of interest and then the researcher can activate the nucleic acid by exposure to light. This system allows temporal controlled expression over exogenous nucleic acids only in targeted cells or selectively regulating endogenous gene expression.

Patents

U.S. Patent 6,017,758: DMNPE caged nucleic acid and vector

U.S. Patent 6,242,258: Methods for the selective regulation of DNA and RNA transcription and translation by photoactivation

U.S. Patent 6,410,327: Methods for the selective regulation of DNA and RNA transcription and translation by photoactivation

Inventors: 
Frederick HaseltonSteve Alexander
Licensing manager: 
Karen Rufus

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