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Method for Modeling Signal Transduction in Cells
This technology provides a model that can be used to describe biological processes having a complex spatial geometry, for example, cell signaling processes. The models can also be used to model the pathology underlying diseases characterized by disrupted signaling pathways, and to identify target proteins at an appropriate site in a signal transduction network such that modulation of the target proteins elicits therapeutic effects. A method of modeling a signal transduction pathway in a cell is provided. Preferably the cell is from a vertebrate, more preferably a warm-blooded vertebrate. In a preferred embodiment, the method comprises determining a simulated geometry of a signaling pathway in a cell; and calculating spatial and temporal diffusion of a chemical species via the simulated geometry of the signal transduction pathway in the cell, whereby signal transduction in the cell is modeled. Optionally, the cell is a rod cell of a vertebrate eye. Methods of modeling diffusion processes, as well as machine-readable products embodying the methods are also disclosed.
Intellectual Property Status
Issued US Patent 7113898
Inventors:Emmanuele DiBenedettoDaniele AndreucciPaolo Bisegna