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Genetic Polymorphisms for Identifying Individuals at Risk for Gentamicin-induced Vestibular Dysfunction
Approximately 5% of patients administered gentamicin, a common antibiotic, experience vestibular ototoxicity, or poisoning of the inner ear resulting in balance dysfunction such as vertigo, dizziness, and imbalance. Vanderbilt researchers and University of Maryland researchers have identified three specific polymorphisms in susceptible genes that are associated with this disorder. These results maybe used for personalized medicine such that a patient could be screened prior to administering the drug allowing the physician to alter the treatment plan for patients that would be at an increased risk for developing this disorder.
Inventors:Scott WilliamsStephen RothJohn Jeka