Assay for Novel Serotonin Transporter Blockers

The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.

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U.S. Patent 7,439,039: Assays for novel serotonin transporter (SERT) blockers

Inventors: 
Randy BlakelyKeith HenryErika Adkins
Licensing manager: 
Karen Rufus

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