This technology allows the simultaneous detection of RNA transcript abundance (as an assay of gene expression) and protein abundance (as an assay of protein expression) from biological samples without RNA isolation, labeling or amplification. Existing technologies allow for very efficient determinations of protein abundance from a wide variety of biological samples. These methods are in widespread use and are based on mass spectrometry technologies. There are no available technologies that allow efficient and quantitative assessment of multiple RNA transcripts without a previous isolation followed by labeling and/or amplification. The most efficient technologies currently available make use of DNA microarrays to profile RNA abundance as a measure of gene expression. While very robust and useful, these technologies are very labor intensive and suffer from a number of technological drawbacks. This technology takes advantage of a number of existing methods and techniques and brings them together in a novel manner that greatly expands the state of the art for gene expression.
A new nanofiber composite membrane morphology and fabrication scheme has been developed at Vanderbilt University to be used for alkaline anion-exchange membrane fuel cells (AAEMFCs). This membrane has high hydroxyl ion conductivity, good mechanical properties, long term chemical stability and low water swelling. Additionally it is well suited for harsh conditions including high temperature and low humidity.
Vanderbilt researchers have developed a novel solid state chemical sensor using CVD diamond film. The system utilizes polycrystalline diamond technology combined with chemically-sensitive electrode layers to achieve high sensitivity and selectivity for a variety of chemical species.
KnowledgeMap is a web accessible comprehensive content management system with robust mapping capabilities across the entire curriculum (at the level of full lectures, not just outlines or syllabi) that facilitates overall design, management, and evaluation of a coherent and coordinated curriculum.
This novel device converts linear motion into nutating motion and can create large angles from small linear displacements. The invention uniquely provides control and precision in the use of nutation motion making it particularly adaptable to micro-applications.
Vanderbilt University researchers have developed an improved flexure based revolute joint which has better properties than a conventional flexure joint. Its split tube design enables a greater range of motion and withstands more load than conventional flexures while eliminating stick-slip and backlash behaviors.
Researchers at Vanderbilt University have developed a novel material with high adsorbent capacity for toxic industrial chemicals of low concentrations in air. Due to the broad range of chemicals that can be adsorbed at these capacities, this technology will replace existing commercial and research grade materials serving as respirator adsorbents and single pass filters for a variety of military and non-military applications.
Thrombosis is the formation of a blood clot inside a blood vessel, which may cause reduced blood flow to a tissue, or even tissue death. Thrombosis, inflammation, and infections are responsible for >70% of all human mortality. Thrombosis is also the major factor for heart disease and stroke. 500,000 die from thrombosis every year in Europe. Inhibitory treatment of these conditions may also improve the outcomes of several non-fatal diseases. Researchers from Vanderbilt University and Oregon Health & Science University have jointly discovered new monoclonal antibodies that potently inhibit the blood coagulation protein factor XII (FXII), a critical player in the pathway, and anticoagulate blood. This invention provides foundation for commercial development of anti-thrombotic drugs based on new molecular entities.
Evaluation and Intervention services are supported by the Patient Advocates Reporting System (PARS). Vanderbilt University Medical Center created the Center for Patient & Professional Advocacy (CPPA) in early 2003 under the direction of Gerald B. Hickson, MD, Associate Dean for Clinical Affairs. Mission: The CPPA's mission is to promote patient and professional satisfaction with healthcare experiences and restrain escalating costs associated with patient dissatisfaction. We pursue our mission through the CPPA's inter-related functions of research, teaching, and intervention services.
We have developed a technique to process photolithographically porous silicon heterostructures and photonic crystal architectures, using laser and ultraviolet light exposure and a subsequent alcoholic bath treatment. This technique would be the first method to process directly the optical properties of porous silicon multilayers, heterostructures, and photonic crystal architectures.
This technology describes a strategy for the synthesis of novel fluorescent thallium indicator dyes, which are useful for high throughput testing of potassium-dependent ion channel or transporter activity.