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Trypterygium Wilfordii II Hook F Extracts as Therapeutic Agents

The present invention provides for the use of Tripterygium wilfordii Hook F extracts and purified components thereof in the treatment of inflammation or an immune disorder with concomitant lack of steroidal effect. Extracts of this plant (T2) bound to the glucocorticoid receptor and competitively inhibited glucocorticoid mediated cellular processes, such as dexamethasone binding to the glucocorticoid receptor, glucocorticoid mediated activation of target genes, dexamethasone dependent cellular growth, with concomitant inhibition of cyclooxygenase-2 induction and inflammatory processes such as the production of prostaglandin E.sub.2. The T2 extract components triptolide and tripdiolide were effective inhibitors. The particular advantage provided by the methods herein is the treatment or prevention of inflammation and the concomitant lack of steroidal agonist effects and NSAID side effects. Conditions treatable by the present methods include inflammation and immune disorders including autoimmune disease.

Point of Care Device for Confirmation of Intravenous (IV) Catheter Placement and Measurement of Peripheral Venous Pressures

Vanderbilt researchers have designed a low-cost, point-of-care device that non-invasively monitors peripheral venous pressure (PVP) to ensure proper placement of peripheral intravenous (PIV) catheters in patients. Use of this device will ensure proper administration of intravenous fluids and intravenous drugs. The device will also prevent the administration of fluid and potent pharmacologic agents into the subcutaneous tissue or fascia, commonly known as "IV infiltration."

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