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285 available technologies

Split-Tube Flexure Joint with Greater Range of Motion

Vanderbilt University researchers have developed an improved flexure based revolute joint which has better properties than a conventional flexure joint. Its split tube design enables a greater range of motion and withstands more load than conventional flexures while eliminating stick-slip and backlash behaviors.

Wireless Tissue Palpation for Minimally Invasive Robotic Surgery Techniques

Researchers in Vanderbilt University's STORM Lab have developed a wireless palpation device that uses magnetic coupling between two units to provide valuable feedback about tissue properties and potential abnormalities. The wireless capabilities of this technology make it ideally suited for minimally invasive surgery and natural orifice procedures, as the device does not require the use of a surgical port.

Nanofiber Composite Membranes for Alkaline Fuel Cells

A new nanofiber composite membrane morphology and fabrication scheme has been developed at Vanderbilt University to be used for alkaline anion-exchange membrane fuel cells (AAEMFCs). This membrane has high hydroxyl ion conductivity, good mechanical properties, long term chemical stability and low water swelling. Additionally it is well suited for harsh conditions including high temperature and low humidity.

A System for Growing Small Populations of Living Cells and Monitoring Their Physiological State

This invention combines the microfluidic and microelectronic devices and techniques required for the microminiaturization of cell culture and cell measurement systems to allow monitoring the response of populations of 1 to several hundred living cells. The instrument(s) allows for the detection of extracellular, membrane, and intracellular parameters; and the incorporation of closed-loop control techniques to continuously monitor the health of the cell and adjust the environmental and pharmacological parameters that control the cell.

Mammalian Genes Involved in Viral Infection and Tumor Suppression

Scientists at Vanderbilt developed a method of identifying of genes, which are necessary for viral growth in cells but nonessential for cellular survival, as well as the methods of treating viral infections based on modification of the function of such genes. The identification of such genes involves the creation of random mutations in single cellular genes by a method which allows the subsequent identification of the mutated gene; selection of cells which remain virus-free after exposure to virus by a method for selectively eliminating persistently infected cells; and subsequent identification of the single mutated gene which precluded viral infection. This invention can be used for identification of host proteins critical for single or multiple virus infection, identification of new molecular targets for antiviral agents and screening of novel antiviral agents.

New Gene Involved in Male Fertility

It is estimated that approximately 30% of men have reduced fertility and 2% are totally infertile. Despite these large numbers relatively little is know about the molecular bases of male infertility. On the flip side of male infertility is the need for male contraception. Currently there are no reversible, convenient male contraceptives available. In order to develop male contraceptives and acquire a greater understanding of male fertility there is a need to develop animal models to study the molecular basis and pathways that regulate and control male fertility. Vanderbilt researchers have developed a model mouse system to study male fertility. There research focuses on the epididymus, which is the area that spermatozoa acquire the ability to move and fertilize. For this region to be functional tissue and cell specific gene regulation must occur. These investigators have discovered one such gene regulated within this area, mEP17. These researchers can fuse either mouse or human EP17 or just the regulatory regions of either EP17 to reporter genes and the resulting fusion can be used to screen for substances that regulate this gene and affect male fertility. This system becomes a powerful tool to identify drugs which affect this gene and be potential male contraceptives. In addition polypeptides generated to this gene may be used as vaccines for male contraceptives.

The Adventures of Jasper Woodbury: videodisc-based adventures that focus on mathematical problem finding and problem solving designed for students in grades 5 and up

The Adventures of Jasper Woodbury™ consists of 12 videodisc-based adventures that focus on mathematical problem finding and problem solving. In particular, each adventure provides multiple opportunities for problem solving, reasoning, communication and making connections to other areas such as science, social studies, literature and history. Jasper adventures are designed for students in grades 5 and up. Each videodisc contains a short (approximately 17 minute) video adventure that ends in a complex challenge. The adventures are designed like good detective novels where all the data necessary to solve the adventure (plus additional data that are not relevant to the solution) are embedded in the story. Jasper adventures also contain "embedded teaching" episodes that provide models of particular approaches to solving problems.

Combined Raman Spectroscopy- Optical Coherence Tomography (RS-OCT)

Vanderbilt researchers have developed an optical system for the differentiation of normal and cancerous skin lesions. The system combines the diagnostic prowess of two separate techniques to provide non-invasive, real-time, in-situ evaluation of lesions.

Mouse Fc-FGF-1

We produced a plasmid containing the Fc portion of mouse IgGl (Fc) coupled to human fibroblast growth factor 1 (FGF-1). The plasmid was transformed into E. coli to express the fusion protein. The fusion protein was purified on a heparin sepharose column which has high affinity for the FGF portion of the fusion protein. The purpose of making this protein was to be able to identify cells that express receptors for FGF using flow cytometry.There are multiple fluorochrome labeled antibodies to mouse IgGl. When the fusion protein is bound to FGF receptors on cells, the Fc portion is on the surface of the cells and can be detected by fluorochrome labeled antibodies to mouse IgGl. Therefore, cells that express FGF receptors and bind the fusion protein can be detected by flow cytometry or immunofluorescence.

Cell Line with Stable Expression of Recombinant Human Chloride Channel, hCIC-4

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human chloride channel (hClC-4). The cells enable high throughput screening of compounds that modulate chloride channel activity.

Cell Line with Stable Expression of Human Skeletal Muscle Sodium Channel (hSkM1)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human skeletal muscle voltage-gated sodium channel (hSkMl). The cells enable high throughput screening of compounds that modulate sodium channel activity.

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