Available Technologies

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295 available technologies

Chemical Sensor Utilizing a Chemically Sensitive Electrode in Combination with Thin Diamond Layers

A solid state chemical sensing device is described in which a chemically sensitive electrode, and at least one diamond film are deposited on a conductive or insulating substrate. The device forms a sensing structure in which conduction of current through the device in the presence of a target chemical is dominated by space charged limited current, thereby providing enhanced sensitivity and selectivity.

Image-Guided Navigation System for Endoscopic Eye Surgery

A flexible endoscope for ophthalmic orbital surgery is presented. The endoscope has illuminating fiber, image fiber and a free conduit to deliver purge gas/fluid in addition to instruments such as ablation instruments, coagulating instrument or a medication delivery instrument.

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.

'Coffee Ring' Diagnostic for Point-of-Care Biomarker Detection

Bright minds at Vanderbilt University have unveiled a breakthrough technology that could bring sophisticated biomarker diagnostics to the developing world. The point-of-care diagnostic is designed to be used in the field; no specialized equipment, expertise, or white lab coats are required. The diagnostic is based upon the ingenous observation that evaporating liquid droplets leave behind a characteristic ring pattern, which may be familiar to our readers in the form of a coffee-ring stain.

Mammalian Genes Involved in Infection

OLINDA/EXM Radiation Dose Assessment Software Application (FDA Approved)

The OLINDA/EXM® personal computer code performs dose calculations and kinetic modeling for radiopharmaceuticals (OLINDA/EXM stands for Organ Level INternal Dose Assessment/EXponential Modeling). OLINDA® calculates radiation doses to different organs of the body from systemically administered radiopharmaceuticals and performs regression analysis on user-supplied biokinetic data to support such calculations for nuclear medicine drugs. These calculations are used to perform risk/benefit evaluations of the use of such pharmaceuticals in diagnostic and therapeutic applications in nuclear medicine. The technology employs a number of standard body models for adults, children, pregnant women and others, that are widely accepted and used in the internal dose community. The calculations are useful to pharmaceutical industry developers, nuclear medicine professionals, educators, regulators, researchers and others who study the accepted radiation doses that should be delivered when radioactive drugs are given to patients or research subjects.

Catheter Having Temperature Controlled Anchor and Related Methods

Heart valve disease is the 3rd most prevalent source of cardiovascular disease, leading to approximately 20,000 deaths per year in the U.S. alone. Moreover, there are an estimated 41,000 mitral valve procedures performed in the U.S. each year. The only effective, long-term treatment for mitral valve disease is open-chest valve replacement surgery, which is highly undesirable for elderly patients. Thus, there is a pressing need to develop novel percutaneous strategies for treatment that will reduce the number of open-chest surgeries. David Merryman and colleagues have developed a new, combined catheter that uses cryo temperatures to adhere to moving mitral valve leaflets and radiofrequency ablation to alter the compliance of the leaflet tissue to prevent prolapse and regurgitation.

A Novel Method for Importing Peptides with Functional Cargo Into the Cells

This technology enables the delivery of biological molecules into the interior of a cell. Such a delivery mechanism could be utilized in a variety of therapies including peptide, gene transfer and/or antisense therapy.

Bioprocess Technology for Synthesis of Chiral Compounds

Commercial routes to industrially important pharmaceutical and agrichemical compounds can often be developed more economically when separation of enantiomeric intermediates/ products is possible. Vanderbilt University seeks to license technologies, originally invented at DuPont, that allow such separations to be performed via novel biocatalysts. Vanderbilt's technology can be used for the production of chiral tertiary esters and/ or enantiomeric amides. In the case of the former class of compounds, our technology is somewhat unique in its ability to operate on carbonyl groups alpha to a tertiary center. See the following description for more information about the current status of this technology and the associated patent estate.

Vanderbilt Performance Evaluation System (VPES) & Job Descriptions Database

Vanderbilt University Medical Center (VUMC) job performance evaluations are part of an annual cycle called performance development in which supervisors and staff members identify and tackle specific job goals with close attention given to the VUMC mission, credo and job descriptions. Many hospital systems, including VUMC, now desire to base annual salary increases largely on performance evaluation ratings. VPES and the Job Description Database allow performance evaluations to be applied consistently and efficiently across the organization.

Clinical Problem Statement Vocabulary For Medical Records

The Canonical Clinical Problem Statement System (CCPSS) is a knowledge base that represents and codes patients' clinical problems. It differs from existing medical coding schemes because it is clinically relevant and contains clinical knowledge regarding the complex interrelationships between medical problems. The CCPSS could form the basis for construction of more thorough and accurate electronically accessible problem lists and will permit epidemiologic studies of problems across institutions.Partial funding for development of the CCPSS project was from the National Library of Medicine (NLM). It is one of the source vocabularies incorporated in the UMLS Metathesaurus, a very large, multi-purpose, and multi-lingual vocabulary database that contains information about biomedical and health related concepts, their various names, and the relationships among them.CCPSS is made available via the NLM website to third parties as a knowledge source under the NLM's Unified Medical Language System (UMLS), for internal research, statistical analysis and development use only. Any other uses, including commercial, require a license from Vanderbilt University.

Gene and Mutations Causative for Familial Primary Pulmonary Hypertension

This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.

Olfactory Genes from the Malaria Mosquito

This technology facilitates the discovery and design of novel agents for either repelling or otherwise controlling insects that have important economic or medical significance. In particular, mosquitoes are responsible for transmitting a number of diseases, including malaria, West Nile, dengue and yellow fevers. The Zwiebel laboratory has identified human odorants and the protein receptors in mosquitoes that allow female mosquitoes to identify their hosts when they need blood to satisfy their reproductive needs. With funding from the Gates Foundation's Grand Challenge in Global Health initiative, the Zwiebel laboratory, along with collaborators at Yale, Wageningen University in the Netherlands, and researchers in Africa, developed biological and behavioral assays to screen and test numerous agents as potential repellants and attractants for the Anopholes gambiae mosquito.
These methods have been applied to include agricultural pests, disease vectors and nuisance insects (important for many tourist-based economies).

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