This technology enables the delivery of biological molecules into the interior of a cell. Such a delivery mechanism could be utilized in a variety of therapies including peptide, gene transfer and/or antisense therapy.
Vanderbilt researchers have developed a novel solid state chemical sensor using CVD diamond film. The system utilizes polycrystalline diamond technology combined with chemically-sensitive electrode layers to achieve high sensitivity and selectivity for a variety of chemical species.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely-used anti-inflammatory and anti-pyretic therapeutic agents to treat human diseases. However, long-term use of NSAIDs comes with risks. Many NSAIDs are COX-1 inhibitors, which are associated with significant GI toxicities. The Marnett Lab at Vanderbilt University has developed new derivatives of NSAIDs that retain their protective effects but do not cause debilitating and potentially fatal toxicities.
The present invention is a method for assessing capillary permeability to determine vascular lung injury without requiring the injection of radioactive material or requiring the sampling of blood. The method includes measuring impedance and ultrasonic velocity of blood flow through a lung. A hypertonic bolus is injected into the blood flow, and measurements of the blood flow are taken to determine the ultrasonic velocity and the electrical impedance of the blood. These measurements are used to calculate the capillary transport quantity, which is the product of the reflection coefficient for movement of fluid across the capillary barrier and the filtration coefficient. The measured value of the capillary transport quantity can then be compared to a conventional capillary transport quantity for healthy lungs, and one can determine injury by a significant decrease in the measured capillary transport quantity as compared to the standard measurements. Furthermore, a comparison of the osmotic transient graphs of the plotted indicator curves can serve to acknowledge lung vascular injury. Lung injury can be determined from the measured data when the point of osmotic equilibrium (where the indicator curve crosses the baseline) is significantly delayed as compared to the point of osmotic equilibrium plotted for a healthy lung.
BCL::Commons:: (BioChemistry Library Commons) is an object oriented C++ programming library. The library is designed to simulate biological molecules - proteins and peptides in particular - as well as small chemicals such as therapeutics. It comprises mathematical methods to evaluate the energy of these molecules in their natural environment. BCL::Jufo is the first publicly released BCL::Commons module.
Researchers in Vanderbilt University's STORM Lab have developed a novel actuation system that uses magnetic coupling to transmit mechanical power across a physical barrier. This technology is particularly suited for use in minimally invasive surgical procedures for manipulating surgical instruments across tissue barriers.
Bright minds at Vanderbilt University have unveiled a breakthrough technology that could bring sophisticated biomarker diagnostics to the developing world. The point-of-care diagnostic is designed to be used in the field; no specialized equipment, expertise, or white lab coats are required. The diagnostic is based upon the ingenous observation that evaporating liquid droplets leave behind a characteristic ring pattern, which may be familiar to our readers in the form of a coffee-ring stain.
Vanderbilt researchers have developed a low-cost, high sensitivity sensor based on a porous silicon (PSi) membrane waveguide. This sensor is designed to be a cost-effective alternative to conventional fiber optic and SPR sensors for both biosensing and chemical sensing applications.
Vanderbilt University researchers have developed an improved flexure based revolute joint which has better properties than a conventional flexure joint. Its split tube design enables a greater range of motion and withstands more load than conventional flexures while eliminating stick-slip and backlash behaviors.
Researchers in Vanderbilt University's STORM Lab have developed a wireless palpation device that uses magnetic coupling between two units to provide valuable feedback about tissue properties and potential abnormalities. The wireless capabilities of this technology make it ideally suited for minimally invasive surgery and natural orifice procedures, as the device does not require the use of a surgical port.