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283 available technologies

PosiSeat™: Assured Seating of Threaded Surgical Components

Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.

MultiUse Multimodal Imaging Chelates

PK11195 is a high-affinity ligand of the peripheral benzodiazepine receptor (PBR). By linking lanthanide chelates to the PK11195 targeting moiety, Vanderbilt researchers have generated a range of PBR-targeted imaging probes capable of visualizing a number of disease states at cellular levels using a variety of imaging modalities (fl uorescence, PET and SPECT, MRI, electron microscopy).

Peptide and Protein Fragmentation by Lysine Residue Originated Reactions

A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.

Human Monoclonal Antibodies to Infectious Diseases

Using human B cell hybridoma creation, and antibody engineering technologies, Dr. James E Crowe Jr.'s laboratory has developed an array of antibodies from full length human antibodies to Fab fragments and diabodies. Many of these antibodies are ready for a cooperate partner who can further develop these antibodies into biologic herapeutics. The table below is a sample of the antibodies they are currently researching and have available. In addition to these areas of research, Dr. Crowe is actively seeking collaborative opportunities to identify new interesting targets for future antibody engineering projects.

Molecular Profiles for Subtyping Triple Negative Breast Cancer

Personalized medicine is at the forefront of medical news and specialized diagnostics that can align patients with the correct treatment are the key to this type of medicine. Jennifer Pietenpol and colleagues have performed extensive research and discovered that triple negative breast cancer (TNBC) is a heterogeneous disease with at least six subtypes. These subtypes have differing biological behaviors and sensitivities to known therapeutics. Diagnostic assays will help guide personalized and more effective therapy.

Multisubstrate Inhibitors of Histone Acetylation Increase the Cytotoxicity of Chemotherapeutic Agents

Inhibitors of histone acetylation may constitute a novel class of potent therapy sensitizers applicable to a broad range of conventional cancer treatments.

A Sensor-Based Online Diagnostic Approach for Physical Systems

This technology addresses the problem of designing and implementing online monitoring and diagnosis systems for complex hybrid systems by focusing on faults that occur in plant components and contains models where faults are represented by changes in system parameters. Hybrid systems are common in the avionics, spacecraft, automotive and robotics domains where behavior is characterized by continuous plant dynamics and discrete supervisory control. These hybrid systems require a tool that analyzes and seamlessly integrates multiple system models on a discrete and continuous basis. As a result, tasks like monitoring, fault diagnosis and control require model selection and switching to be performed online as system behavior evolves.

Novel Esters and Amides Derived from Indolealkanol and Indolealkylamines as Selective Cyclooxygenase-2 (Cox-2) Inhibitors

A compound of the formula ##STR1## where: n, and X are as defined in the specification, and the compound possesses selectivity for inhibition of cyclooxygenase-2.

Integrated Device for Leaching Extraction and Assessment

The invention is a device which permits the direct quantification of leachable organic constituents from within solid materials. It is expected that the device will be used in landfills and in other environments where measurements are central to the evaluation of the environmental compatibility of solid materials (e.g., sediments, soils, solidified waste forms) containing organic constituents that have the potential to degrade water resources of to be taken up by biota and the food chain. The invention is designed to simplify current difficulties in assessing leaching of organic constituents with low aqueous solubility.

A Conditionally Lethal Helicobacter Pylori Strain

Vanderbilt University researchers have characterized an H. pylori specific gene, dapE, which can be used to generate novel, targeted therapeutics for H. pylori-induced infections in the stomach. The gene encodes an enzyme responsible for the synthesis of the amino acid lysine. Most bacterial species have redundant pathways for amino acid synthesis because they are essential for life, however H. pylori is unique in that it has only one pathway for lysine biosynthesis. In an era when antibiotic resistance has become a significant hurdle in combating bacterial infections, this gene target provides a new, antibiotic independent, modality to combat H. pylori infection. Conditionally-mutant DapE H. pylori strains can be licensed directly for use as a research tool.

HEK-293 cell line overexpressing neuronal potassium chloride cotransporter

KCC2 is a neuronal-specific K-CI cotransporter which plays a major role in maintaining intracellular Cl- concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses.

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