Available Technologies

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292 available technologies

Expression vector for Leukocyte-Type 12-Lipoxygenase

Use of Holliday Junction Resolvase as a Method for DNA Subcloning

Inhibitors of Inward-rectifying potassium channels (insecticide)

Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard "click" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.

Gene Signature Diagnostic to Measure LKB1 Loss and MEK Inhibitor Sensitivity

A Vanderbilt research group has discovered a diagnostic to identify patients with non-small cell lung cancer that would respond to MEK inhibitor therapies. This diagnostic indirectly measures loss of tumor suppressor activity by the protein LKB1. The traditional approach to determine MEK inhibitor sensitivity, which is measurement of LKB1 mutations, misses 50% of patients who would benefit from these drugs. This diagnostic measures expression of a small panel of genes to identify a larger population that is sensitive to MEK inhibition.

Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

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2012 Highlights

A motion graphic video describing operational improvements and successes of FY2012. Click here for a full PDF report.