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295 available technologies

Inhibitors of Inward-rectifying potassium channels (insecticide)

Colorectal Cancer Risk Screening Assay

The overall lifetime colorectal cancer risk for Americans is 5.1%, thus screening is recommended for those over the age of 50. Currently, colonoscopies are the standard for monitoring colon cancer development, but are invasive. Therefore, a need exists for a minimally-invasive test that could measure colon cancer risk. Ideally, such a test would offer a straightforward, personalized recommendation on how to substantially reduce colorectal cancer risk. Researchers at Vanderbilt University have identified a test that can characterize colorectal cancer risk and recommend a strategy for risk reduction. Importantly, this test requires only a blood sample and information about a person's diet.

Collapsible Lightweight PortableLeg Holder for Ultrasound GuidedLateral Popliteal Block Procedures

A Vanderbilt team led by anesthesiologist Dr. Rajnish Gupta has developed a collapsible, lightweight and portable patient leg positioner for secure and stable leg positioning during ultrasound guided nerve block anesthetic procedures.

Novel Fused Heterocyclic Compound as Selective BMP Inhibitors

KidSense Car Seat System

Two Dimensional Ultra Short Echo Time MRI via Slice Saturation

Novel saturation-based method for creating a 2D MR image of a slice of interest from an object is described. This method does not use gradients during excitation, which allows for the minimum echo time and greatly reduces sensitivity to gradient imperfections. Two signals are acquired -- one from the entire sample without spatial selection; the second from the entire sample following a slice saturation preparation. The difference between the two signals results in the signal only from the saturated 2D slice. The sequence has been implemented on both human (Philips) and animal (Agilent) scanners.

Metabolic Labeling Reagents for Chondroitin Sulfate

Dr. Patrick Page-McCaw has developed synthetic analogs of N-acetylgalactosamine, finally enabling researchers to track the biosynthesis of chondroitin sulfate along with other glycans. These stunning images demonstrate incorporation of these metabolic labeling reagents to track neurodevelopmental processes in a zebrafish model system. Notably, the metabolic label can be detected post vivo using a standard "click" chemistry reaction. Further, Dr. Page-McCaw has optimized a background reduction strategy to complement this technology by improving the signal-to-noise ratio.

Gene Signature Diagnostic to Measure LKB1 Loss and MEK Inhibitor Sensitivity

A Vanderbilt research group has discovered a diagnostic to identify patients with non-small cell lung cancer that would respond to MEK inhibitor therapies. This diagnostic indirectly measures loss of tumor suppressor activity by the protein LKB1. The traditional approach to determine MEK inhibitor sensitivity, which is measurement of LKB1 mutations, misses 50% of patients who would benefit from these drugs. This diagnostic measures expression of a small panel of genes to identify a larger population that is sensitive to MEK inhibition.

Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

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