Available Technologies

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300 available technologies

Human Choline Transporter cDNA

Vanderbilt researchers report the isolation and characterization of a human cDNA encoding the high affinity, hemicholinium-3 sensitive choline transporter. This transporter is expressed in cholinergic terminals, and it provides for transport into cholinergic terminals of choline, the precursor for acetylcholine biosynthesis. The cDNA, through HC-3 radio ligand binding assays or choline transport assays, allows for high-throughput screening of choline transporter directed agents or as a negative screen to insure specificity for nicotinic and muscarinic acetylcholine receptor-directed agents (as well as other pharmaceutics). The choline transporter in vivo is highly regulated, and the human choline transporter's regulation is poorly understood. Use of the cDNA may allow for the development of novel cholinergic therapeutics targeted at choline transporter modulation. Antibodies directed against the human choline transporter should be useful probes of human cholinergic neurons. Sequences in the human choline transporter cDNA should allow for the generation of transporter specific gene probes that can be queried by in situ hybridization, PCR analyses of transporter gene expression or gene chip approaches evaluating alterations in presynaptic cholinergic function.

Highly Accurate Radio Chip Localization Technology

Summary: This technology, developed at Vanderbilt University's Institute for Software Integrated Systems, uses radio interferometry to locate tangible objects and attains, simultaneously, a higher degree of accuracy (within 3 centimeters), considerably longer range (up to 160 meters) and lower cost than other technologies.

Stable HERG Expressing Cells

Vanderbilt researchers have designed a cell line with stable expression of the human heart potassium channel, HERG. This cell line has robust and very consistent cell-to-cell HERG activity without detectable endogenous ionic currents, making it ideal to use in preclinical drug screening.

Novel PLD Inhibitors

Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.

Brain Shift Compensation Using Computer Models

This technology eliminates the need to place cortical fiducial markers during image guided neurosurgery. As an additional and important feature, the technology is able to compensate for brain shift due to deformation of the brain during surgery.

Through the Tool Tracking for Friction Stir Welding

Utilizing force sensors mounted on the friction stir welding tool, Vanderbilt inventors have developed a technique to keep a weld tool on track. This technology is especially benefi cial in real time corrections for deviations in travel in the case of robotic FSW or "blind" welds. The technique is cost- effective in that no additional sensors such as cameras, thermocouples, acoustic emission receivers, etc. are required.

Magnetically Attachable Polydimethylsiloxane Stencils (MAtS)

Vanderbilt researchers have developed a unique system for patterning cells or proteins in cell culture environments using magnetically attachable stencils (MAtS) secured onto a culture surface by applying transbase magnets.

Rotary planar peristaltic micropump (RPPM) and Rotary Planar Valve (RPV) for microfluidic systems

A research team led by Professor John Wikswo of Vanderbilt University has developed a low-cost, small-volume, metering peristaltic micro pumps and microvalves. They can be either utilized as a stand-alone device, or incorporated into microfluidic subsystems for research instruments or miniaturized point-of-care instruments, Lab on a Chip devices, and disposable fluid delivery cartridges. The key advantage of this pump is that it can deliver flow rates as low as a few hundred nL/min to tens of µL/min against pressure heads as high as 20 psi, at approximately 1/10th the cost of stand-alone commercial syringe and peristaltic pumps. The RPV can implement complicated fluid control protocols and fluidic mixing without bulky pneumatic controllers. Both the RPPM and RPV can be readily optimized for particular applications.

Bright White Light Nanocrystals for LEDs

A research team lead by Professor Sandra Rosenthal at Vanderbilt University has developed nanocrystals (~2 nm diameter) that emit white light with very high quantum efficiency. This technology would be a viable cost effective candidate for commercial solid-state lighting applications, such as Light Emitting Diodes (LEDs). These nanocrystals were originally discovered by the same group in 2005; a recent breakthrough in post-treatment results in improving fluorescent quantum yield up to ~ 45%.

Arbitrary Shape Selective Excitation Summed Spectroscopy (ASSESS)

Vanderbilt researchers have developed a novel single-voxel localization technique for Magnetic Resonance Spectroscopy (MRS), termed ASSESS (Arbitrary Shape Selective Excitation Summed Spectroscopy). ASSESS can measure spectra from regions of arbitrary shape allowing the user to customize the region of interest.

System and Methods of Using Image-guidance for Placement of Cochlear Stimulator Devices, Drug Carrier Devices, or the Like

Vanderbilt inventors have developed and tested a device (C-in) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure.

PosiSeat™: Assured Seating of Threaded Surgical Components

Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.

MultiUse Multimodal Imaging Chelates

PK11195 is a high-affinity ligand of the peripheral benzodiazepine receptor (PBR). By linking lanthanide chelates to the PK11195 targeting moiety, Vanderbilt researchers have generated a range of PBR-targeted imaging probes capable of visualizing a number of disease states at cellular levels using a variety of imaging modalities (fl uorescence, PET and SPECT, MRI, electron microscopy).

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