Vanderbilt researchers have designed a low-cost, point-of-care device that non-invasively monitors peripheral venous pressure (PVP) to ensure proper placement of peripheral intravenous (PIV) catheters in patients. Use of this device will ensure proper administration of intravenous fluids and intravenous drugs. The device will also prevent the administration of fluid and potent pharmacologic agents into the subcutaneous tissue or fascia, commonly known as "IV infiltration."
Scientists at Vanderbilt have developed a novel therapy for gliobastoma multiform that results in minimal recurrence of the tumor. The therapy combines two inhibitors that effectively compromise tumor cell growth and survival. The therapy can be followed by radiation, a common treatment for cancer cells.
The sheer volume of medical information available to physicians today is overwhelming. Diagnostic Management Team provides a concise, accurate method for ordering the correct diagnostic tests every time, and it returns the results in a uniform report format, easily read by the physician. This has already been launched within Vanderbilt University, with a high adoption rate amongst physicians and has already shown significant savings.
Dr. Hawiger and colleagues developed a novel form of cell-penetrating fetal hemoglobin. This technology is useful for the treatment of hemoglobinopathies or to increase oxygen delivery in any condition. The preparation is stable and sterile. Upon reconstitution, the treatment can be delivered I.V. or through transfusion.
D-3-Hydroxybutyrate (3-HB) cell culture medium is useful for studying cancer cells lines in a novel, but physiologically relevant, metabolic context. Cancer cells are known to have rapid glucose metaobolism and most cell-based research is carried out in glucose containing medium. Cancer cells alternatively use 3-HB as a carbon source, which is a prevalent metabolic substrate when fasting. 3-HB medium offers researchers the chance to study cell growth and chemotherapuetic agents in this novel and frequently overlooked context.
This technology describes a novel methodology wherein human-induced pluripotent stem cells can be differentiated into neural precuror cells using DMH1 (a dorsomorphin analog). Neural progenitor cells can then be further differentiated into tyrosine hydroxylase expressing neurons.
The mouse embryonic stem cell line, CGR8, has been genetically modified to express luciferase under the control of either the wnt or the BMP promoter system. This technology allows rapid visualization or genetic modification of wnt and BMP pathways in development.
Transforming growth factor (TGF) beta type II receptor antibodies directed towards the extracellular domain (epitope 4-19) are available from the laboratory of Harold Moses. TGF-beta-II plays an important role in several biological processes including developmental biology, cardiovascular biology and cancer.
The most common counter electrode materials used for in Quantum dot sensitized solar cells (QDSSCs) quickly become poisoned by sulfide, resulting in significant current drops, which lowers solar cell efficiencies and makes them unsuitable for long-term use in a device. Also, some of these materials are rare and expensive, so replacing them with an inexpensive, earth-abundant material is a desirable goal. This invention uses a Mo foil to produce the desired uniform growth of Molybdenum (IV) disulfide (MoS2) petals from the Mo foil, making the foil both the source of Mo as well as the substrate. This petaled MoS2 electrode shows a vastly improved polysulfide reduction compared to Glassy Carbon, ordinary Mo foil, Pt and Au. The petaled MoS2 electrode lost only 0.63% of its initial current density at -1 V whereas Pt lost 13.58% after only five scans, indicating the petaled MoS2 films are highly stable as cathodes. The technology was tested in a solar device setting, using standard photoanodes to test the efficiency of a device employing petaled MoS2 as its cathode. Devices in which a petaled MoS2 cathode was used achieved nearly fivefold improvement in efficiency over those employing a Pt cathode.
Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds. The present invention is a pulse sequence that efficiently transforms parahydrogen spin order into heteronuclear magnetization. This was achieved via a single streamlined sequence without recursive application, by finding sequential analytic solutions to the density matrix evolution for each of four independent intervals that collectively flank two proton inversions and one heteronuclear excitation. The name hyper-SHIELDED (Singlet to Heteronuclei by Interative Evolution Locks Dramatic Enhancement for Delivery) reflects the sequence's protective effect on PHIP hyperpolarization.