Available Technologies

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300 available technologies

Software for interactive registration and visualization of tomographic medical images

1) The visualization (2D and 3D) of images. Its main area of application is thevisualization of tomographic medical images data sets2) the interaction with these data sets. The software permits the manual alignment of datasets, the delineation of regions of interest (both in 2D and in 3D), the import and export of these regions of interest, the display of these regions both as contours or as surfaces, as well as the processing of the images (filtering, image enhancement, etc.)3) The registration of medical images. This software has been designed to permit therealignment of multiple data sets. This realignment can be performed manually and interactively or it can be performed automatically. In the latter case, transformations that permit the realignment of the images can be imported in the software that uses these transformations to realign the images. The software is designed to accept a wide variety of transformations ranging from rigid transformations to non-rigid transformations. These transformations can be modified interactively and re-exported.The software runs on any computer on which the IDL virtual machine runs (currently Windows, Unix, and Mac OS). The software is designed to be user friendly but it does not currently include a user's manual.

Adjustable Universal Platform for Surgical Navigation, Approach, and Implantation

A surgical platform usable for performing a surgical procedure. In one embodiment, the surgical platform comprises a base portion configured to receive at least one probe; a plurality of adjustable legs configured to support the base portion, each adjustable legs having a first end portion and an opposite, second end potion defining a length therebetween; and at least one movable portion configured to adjust the length of at least one adjustable leg.

Micro-Mirrored Pyramidal Wells

This technology is a system for 3D imaging of live biological cells fabricated using conventional semiconductor technology that provides simultaneous images from multiple vantage points.

Trimodal Handheld Probe Based on Raman Spectroscopy and Confocal Imaging for Cancer Detection

This technology relates to a device and method for non-invasive evaluation of a target of interest of a living subject, and in particular to devices and methods that integrate confocal imaging with confocal Raman spectroscopy, for non-invasive evaluation of the biochemical compositions and morphological details of normal and cancerous skin lesions of a living subject.

Helical Peristaltic Nanopump for BioMEMS Devices

A metering rotary nanopump for driving BioMEMS and microfluidic systems.

High Energy - Density Hydraulic Accumulator

Vanderbilt inventors propose an inexpensive and easy to manufacture hydraulic accumulator. The proposed hydraulic accumulator technology is intended for energy storage. It is superior to current alternatives in that it provides a simple, efficient and relatively cheap method for storing a large amount of energy in a relatively small volume and mass. One example of its application would be in regenerative braking of passenger vehicles (hydraulic hybrid).

Optical Stimulation of the Auditory Nerve

A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {L.sub.i}, placeable distal to the cochlea, each light source, L.sub.1, being operable independently and adapted for generating an optical energy, E.sub.i, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {L.sub.i}, such that in operation, the optical energies {E.sub.i} generated by the plurality of light sources {L.sub.i} are delivered to target sites, {G.sub.i}, of auditory neurons, respectively, wherein the target sites G.sub.1 and G.sub.N of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.

System for Stabilizing Phase of a Picosecond Laser Sysem to an RF Accelerator

The invention relates to an improved method and system for synchronizing signals in a particle accelerator system. In one embodiment, a method and system is disclosed whereby a phase of laser pulses are monitored, and a high-frequency signal is adjusted as necessary to be substantially in-phase with the laser pulses. In another embodiment, a method and system is disclosed whereby a phase of an electromagnetic field in an electron gun is monitored, and a high-frequency signal is adjusted as necessary to be substantially in-phase with the electromagnetic field.

Functional Polymorphism in IL7R is Significantly Associated with Multiple Sclerosis

This technology has identified a genetic marker to aid in the diagnosis of patients with multiple sclerosis as well as to identify patients whom have an increased risk of developing the disease.

Algorithm for Age Related Macular Degeneration Prediction

Age-related Macular Degeneration (AMD) is the leading cause of blindness in elderly patients in developed countries, affecting approximately 7.5 million Americans. Recently several genetic and environmental factors have been implicated as susceptibility factors. We have developed an algorithm which can incorporate all of the risk factors a patient may have and determine a risk value for which they may be susceptible for developing AMD. Currently there is no predictive test for identifying individuals that are at risk for developing AMD rather individuals are screened after the age of 60 for the presence of the disease. This test would allow individuals who are at risk of developing AMD to be identified prior to onset of the disease so that preventative steps may be taken and delay or prevent AMD from occurring.

Genome Wide Association Analysis of the Age-at-Onset for Individuals with Alzheimer's Disease

Late-Onset Alzheimer's Disease (LOAD) is a complex disorder with a strong genetic component. Previous studies suggest that genetic variants contribute to not just LOAD susceptibility, but to the variation of the age-at-onset (AAO). Millions of people suffer from this disease but until now there has been no way to predict the probably age at which the disease would begin to manifest. A genome-wide analysis of multitude of single nucleotide polymorphism (SNP's) was performed on a large population of patients. The importance of identifying SNP's that are associated with a disease allows the comparison on regions of the genome between affected and non-affected individuals. When strong associations are made they allow us to predict the likelihood of an individual being affected by the disease. In this case not only the disease but a prediction of the age at which the individual will be affected can be predicted.

Genome-Wide Association Study of Autism Reveals a Common Novel Risk Locus

Autism is a brain development disorder characterized by impaired social interaction, impaired communication, and restricted and repetitive behavior, all starting before a child is three years old. Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether autism is explained more by multigene interactions or by rare mutations. Vanderbilt and University of Miami researchers have identified a small nucleotide polymorphisms (SNP) on chromosome 5 which associates with autism. This SNP could be developed for early detection of this disease. Diagnosis of autism can be difficult and typically not done until children have difficulty with social interactions. If autism could be identified at an earlier stage then behavior modifications could be introduced to help children preventing many of the restrictive behavior these children have.

Genetic Polymorphisms for Identifying Individuals at Risk for Gentamicin-induced Vestibular Dysfunction

Approximately 5% of patients administered gentamicin, a common antibiotic, experience vestibular ototoxicity, or poisoning of the inner ear resulting in balance dysfunction such as vertigo, dizziness, and imbalance. Vanderbilt researchers and University of Maryland researchers have identified three specific polymorphisms in susceptible genes that are associated with this disorder. These results maybe used for personalized medicine such that a patient could be screened prior to administering the drug allowing the physician to alter the treatment plan for patients that would be at an increased risk for developing this disorder.

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