Vanderbilt researchers, led by Eric Skaar, Ph.D., have identified novel compounds that are antimicrobial. These compounds represent a first in class as they target a new bacterial pathway that has never been targeted as an antimicrobial strategy.
Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e.g., anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention.
This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.
Since the discovery of antibiotics in the 1940' and 1950's no signifi cant advances have been made in the treatment of wounds. One of the most formidable challenges to effecting tissue repair and regeneration is to direct the orchestrated proliferation and organization of multiple cell types to recapitulate structure and function of the damaged organ. Pampee Young, Ethan Lee and colleagues have data to show that modulations of tissue resident stem cells represent a central mechanism that impacts repair and regeneration.
An electrophoresis chamber having the separation capability of a thicker chamber by the addition of a number of ports along the length of the chamber that can act as inlets or outlets. The device introduces cross flow by either a plurality of input and output ports along opposite walls of the chamber or by a tapered chamber having a plurality of output ports. Since the mobility of the particles is lateral to the direction of flow and the cross flow velocity is opposite in direction and greater than the maximum electrophoretic velocity of the particles being separated such particles are carried to the wall of a narrow linear chamber and will pass through ports provided in the wall spaced at strategic distances along the wall separation is achieved. In addition, because the sample and the outlet electrode surface are of like sign there is no deposition of the sample on the electrode surface.
This new materials processing technology allows metal and ceramic parts to be manufactured in three dimensions by additive deposition of material, either in atmosphere or in a vacuum. The scale is on the order of the powder size and can be as small as one micron. The deposition rate can be orders of magnitude greater than vapor deposition, which is the current vacuum fabrication technology for devices.
This program permits the automatic registration (spatial realignment) of 2D and 3D mono- and multi-modal medical images. In its current form it uses Mutual Information as the similarity measure. It supports multi-resolution schemes and transformations up to 12 degrees of freedom.
This technology is fundamentally a new way to align a patient in an image-guided surgery system (registration) without the use of fiducial markers on the cranium exterior. The system utilizes laser range scanning technology, the natural features on the cortical surface, and the corresponding natural features derived from the patient's preoperative magnetic resonance tomograms. In addition, the technology is amenable to measuring deformation (brain shift) for use within a mathematical model-based strategy for shift compensation.
Elastography is the direct imaging of tissue elasticity parameters. The invention is a method of modeling of tissue called Modality Independent Elastography (MIE), within the context of dermoscopy imaging, for the purpose of optimizing the similarity between model-created images and the patient acquired images.
Simon (Signal Interpretation and Monitoring) is an ongoing research and development effort at Vanderbilt University. Simon's overall goal is to provide effective computerized medical decision support in critical care through novel collection, analysis, and presentation of physiologic data from bedside medical devices.
1) The visualization (2D and 3D) of images. Its main area of application is thevisualization of tomographic medical images data sets2) the interaction with these data sets. The software permits the manual alignment of datasets, the delineation of regions of interest (both in 2D and in 3D), the import and export of these regions of interest, the display of these regions both as contours or as surfaces, as well as the processing of the images (filtering, image enhancement, etc.)3) The registration of medical images. This software has been designed to permit therealignment of multiple data sets. This realignment can be performed manually and interactively or it can be performed automatically. In the latter case, transformations that permit the realignment of the images can be imported in the software that uses these transformations to realign the images. The software is designed to accept a wide variety of transformations ranging from rigid transformations to non-rigid transformations. These transformations can be modified interactively and re-exported.The software runs on any computer on which the IDL virtual machine runs (currently Windows, Unix, and Mac OS). The software is designed to be user friendly but it does not currently include a user's manual.