Available Technologies

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283 available technologies

Filament Based Point-of-Care Platform

Vanderbilt engineers have developed a robust platform for point-of-care (POC) diagnostics applicable to infectious diseases, biowarfare agents and environmental and agricultural testing. This technology uses capture antibodies on a polyester filament, or DNA, on a gold wire that act as molecular hooks to troll for viral or bacterial protein antigens, RNA or capture DNA present in a small biological sample solution. It is envisioned that once the analytical POC device is purchased, a different single-use filament would be sold for each pathogen test of interest.

Method for Regulation of DNA and RNA Transcription and Translation

Vanderbilt researchers have discovered and patented a means of selectively expressing genes of interest in specific cells. This research tool allows an inactive nucleic acid to be delivered to a specific cell of interest and then the researcher can activate the nucleic acid by exposure to light. This system allows temporal controlled expression over exogenous nucleic acids only in targeted cells or selectively regulating endogenous gene expression.

Heterologous Expression System for Studying Recombinant Human Brain Voltage-Gated Sodium Channel, SCN1A

Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.

Cell Line with Stable Expression of Human Cardiac Sodium Channel (hH1, a.k.a. hNav1.5, SCN5A)

The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.

Maternal Fetal Neonatal Database

Vanderbilt researchers and clinicians have developed a database and web application that tracks unborn fetuses as a separate patient population. Traditionally unborn fetuses are monitored and tracked for abnormalities and all of their information and documentation is placed within the mother's medical chart. This program creates a separate medical file for the unborn fetus that is linked to the maternal medical file. This system allows clinicians to easily sort and track unborn fetus abnormalities and easily identify treatment options that have shown to be beneficial to that patient population, ultimately improving clinical outcomes.

Antimicrobial Compounds and Methods of Use Thereof

Vanderbilt researchers, led by Eric Skaar, Ph.D., have identified novel compounds that are antimicrobial. These compounds represent a first in class as they target a new bacterial pathway that has never been targeted as an antimicrobial strategy.

Use of mGluR5 Partial Antagonists for the Treatment of Anxiety and Other CNS Disorders

Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e.g., anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention.

Caden IP Purchase

This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.

Use of Wnt Inhibitors for Wound Healing

Since the discovery of antibiotics in the 1940' and 1950's no signifi cant advances have been made in the treatment of wounds. One of the most formidable challenges to effecting tissue repair and regeneration is to direct the orchestrated proliferation and organization of multiple cell types to recapitulate structure and function of the damaged organ. Pampee Young, Ethan Lee and colleagues have data to show that modulations of tissue resident stem cells represent a central mechanism that impacts repair and regeneration.

Continuous Flow Electrophoresis Apparatus

An electrophoresis chamber having the separation capability of a thicker chamber by the addition of a number of ports along the length of the chamber that can act as inlets or outlets. The device introduces cross flow by either a plurality of input and output ports along opposite walls of the chamber or by a tapered chamber having a plurality of output ports. Since the mobility of the particles is lateral to the direction of flow and the cross flow velocity is opposite in direction and greater than the maximum electrophoretic velocity of the particles being separated such particles are carried to the wall of a narrow linear chamber and will pass through ports provided in the wall spaced at strategic distances along the wall separation is achieved. In addition, because the sample and the outlet electrode surface are of like sign there is no deposition of the sample on the electrode surface.

System & Method for Direct Fabrication of Micro/Macro Scale Objects in a Vacuum Using Electromagnetic Steering

This new materials processing technology allows metal and ceramic parts to be manufactured in three dimensions by additive deposition of material, either in atmosphere or in a vacuum. The scale is on the order of the powder size and can be as small as one micron. The deposition rate can be orders of magnitude greater than vapor deposition, which is the current vacuum fabrication technology for devices.

Software for MIAIR (Mutual Information Affine Image Registration)

This program permits the automatic registration (spatial realignment) of 2D and 3D mono- and multi-modal medical images. In its current form it uses Mutual Information as the similarity measure. It supports multi-resolution schemes and transformations up to 12 degrees of freedom.

Software for Adaptive Basis Non-Rigid Registration Algorithm

This program permits the automatic non-rigid registration (spatial realignment) of 2D and 3D mono-and multi modal images.

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