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A Conditionally Lethal Helicobacter Pylori Strain

Vanderbilt University researchers have characterized an H. pylori specific gene, dapE, which can be used to generate novel, targeted therapeutics for H. pylori-induced infections in the stomach. The gene encodes an enzyme responsible for the synthesis of the amino acid lysine. Most bacterial species have redundant pathways for amino acid synthesis because they are essential for life, however H. pylori is unique in that it has only one pathway for lysine biosynthesis. In an era when antibiotic resistance has become a significant hurdle in combating bacterial infections, this gene target provides a new, antibiotic independent, modality to combat H. pylori infection. Conditionally-mutant DapE H. pylori strains can be licensed directly for use as a research tool.


Novel PLD Inhibitors

Vanderbilt researchers have created the first isoform-selective phospholipase D (PLD) inhibitors. These highly potent inhibitors can significantly reduce PLD activity, creating a new class of anti-metastatic agents.


Mice Expressing Homozygous Human SCN5A (the Canonical Cardiac Sodium Channel) for the Study of Long QT Syndrome

Transgenic mice homozygous for the human cardiac sodium channel SCN5A gene (human-SCN5A H/H mice), on a C57 and 129sv background. These mice can be used to study function of the post-depolarization sodium current and gender-dependent long QT-related arrhythmias.


Inventors

Dan Roden , Mark Magnuson
Research Tools
Animal Model
Cardiovascular

Novel Antimicrobial Peptide Isolated From Hydrothermal Vent-Dwelling Archaea

A new broad-spectrum antimicrobial enzyme for industrial and biopharmaceutical applications is undergoing characterization by Dr. Seth Bordenstein's laboratory at Vanderbilt University. It is expected to have unique therapeutic properties such as thermostability and tolerance of acidic environments.