MOOSES (Multi-Option Observation System for Experimental Studies). This software system makes it easy to collect and analyze data about any type of real time events. Data can be collected using your PC, a laptop, A handheld PC, or a PocketPC and later analyzed on several dimensions. Data collected from digital audio and video files using ProcoderDV can also be analyzed using MOOSES. This type of data can help you make accurate assessment of what is happening in the real time system you are observing. Several analysis options are provided and described at the website.
Robust and accurate sensor fusion algorithm using time of arrival data for acoustic event localization. The fusion algorithm compensates for incorrect measurements including multipath effects. The algorithm is capable of localizing multiple simultaneous sources with a high degree of accuracy.
This technology addresses the problem of designing and implementing online monitoring and diagnosis systems for complex hybrid systems by focusing on faults that occur in plant components and contains models where faults are represented by changes in system parameters. Hybrid systems are common in the avionics, spacecraft, automotive and robotics domains where behavior is characterized by continuous plant dynamics and discrete supervisory control. These hybrid systems require a tool that analyzes and seamlessly integrates multiple system models on a discrete and continuous basis. As a result, tasks like monitoring, fault diagnosis and control require model selection and switching to be performed online as system behavior evolves.
Contextualized feedback intervention and training protocol is a form assessment. It enables behavioral healthcare practitioners to assess and categorize the behavioral health status of patients in a mental health context. It also provides a training protocol for providers.
ListVUe is a software tool that permits the expeditious search of the United States Department of Commerce Export Control with a higher degree of accuracy than is currently available. This product is designed for any company or institution which is required to comply with U.S. export control laws and regulations.
Vanderbilt engineers have developed a robust platform for point-of-care (POC) diagnostics applicable to infectious diseases, biowarfare agents and environmental and agricultural testing. This technology uses capture antibodies on a polyester filament, or DNA, on a gold wire that act as molecular hooks to troll for viral or bacterial protein antigens, RNA or capture DNA present in a small biological sample solution. It is envisioned that once the analytical POC device is purchased, a different single-use filament would be sold for each pathogen test of interest.
Vanderbilt researchers have discovered and patented a means of selectively expressing genes of interest in specific cells. This research tool allows an inactive nucleic acid to be delivered to a specific cell of interest and then the researcher can activate the nucleic acid by exposure to light. This system allows temporal controlled expression over exogenous nucleic acids only in targeted cells or selectively regulating endogenous gene expression.
Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.
The invention is a cell line (Human embryonic kidney 293) stably expressing a recombinant human cardiac voltage-gated sodium channel (hHl). The cells enable high throughput screening of compounds that modulate sodium channel activity.
Vanderbilt researchers and clinicians have developed a database and web application that tracks unborn fetuses as a separate patient population. Traditionally unborn fetuses are monitored and tracked for abnormalities and all of their information and documentation is placed within the mother's medical chart. This program creates a separate medical file for the unborn fetus that is linked to the maternal medical file. This system allows clinicians to easily sort and track unborn fetus abnormalities and easily identify treatment options that have shown to be beneficial to that patient population, ultimately improving clinical outcomes.
Vanderbilt researchers, led by Eric Skaar, Ph.D., have identified novel compounds that are antimicrobial. These compounds represent a first in class as they target a new bacterial pathway that has never been targeted as an antimicrobial strategy.
Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e.g., anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention.
This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these methods also are disclosed.