The mutant SERTs we have developed can provide for a platform to screen for novel modes/molecules interrupting SERT function. As SERT blockers are effective antidepressants, this strategy can lead to novel antidepressant medications. It may also be useful in development of animal models to test antidepressant action in vivo.
The only MMP-7-null mouse that has been generated. Used to determine biological function of MMP-7. Mice have been used in more than 10 publications at this point, and will be distributed by a commercial vendor in the near future.
The mutation allows for the first genetic test to be conducted for one form of chronic fatigue or mitral valve prolapse which we describe as orthostatic intolerance or postural tachycardia syndrome (POTS). The technology allows for the development of this test and the development of other tests in the same gene at other loci that may contribute to similar illnesses. The awareness of a phenotype associated with the mutation in the antidepressant-sensitive NET allows for evaluation of the role of the NET gene in mental illness and thus the development of genetic tests for increased susceptibility to mental and autonomic illnesses. This is the first neurotransmitter transporter gene defect that has been shown to be linked to a disorder. The precedent act opens the door for screening for other genetic mutations in genetically related transporters such as the serotonin transporter or dopamine transporter. These latter transporters have been implicated in depression anxiety, pscyhostimulant abuse (cocaine/amphetamine) and attention-deficit disorder. Our work allows for genetic inspection of transporter genes associated with these disorders. Our work may also allow for an examination of whether circulating antibodies against the NE transporter are contributory to OI or other chronic fatigue disorders.
In 2009 over 70,000 American were diagnosed with urinary bladder cancer, and in that same year over 14,000 Americans died of bladder cancer. Low funding for bladder cancer helps explain the slow progress in both the identification of biomarkers and the development of new treatments for metastatic bladder cancer. Nonetheless, novel diagnostic biomarkers are needed to aid in the early identification of patients with bladder cancer, and also to determine which patients are likely to progress. Vanderbilt researchers have identified such a biomarker whose expression is reduced and lost during progression of bladder cancer.
CORES™ is a highly configurable, enterprise-wide software solution for research institutions. CORES™ provides full central oversight while also allowing for flexible but consistent decentralized billing and usage functionality for core facilities. This software allows core managers and customers to enter orders using a variety of methods. The software also allows customers in product cores to scan their items at a self-service checkout terminal that provides full real-time inventory management. Orders are accumulated into electronic invoices and e-mailed to customers each month. An electronic upload file containing order information is also created for the finance department. Vanderbilt has approximately 90 internal cores using this software. In addition, the software is used by several other institutions to whom the software has been licensed.
The Patient Safety Screening Tool (PSST) for Sepsis solution is a tool to assist with the early detection of Sepsis and management of the administration of bundle packages as defined by the Institute for Healthcare Improvement (IHI). This web based application relies on integration with bedside medical equipment (BME) data as well as Lab and Registration data so that clinical workflow items can be automated in the fight against Sepsis.
Play Nicely is a video series developed by a professor of pediatrics for parents of and for teachers and day care providers who are responsible for pre-school age children. The video series offers advice on how to deal with anti-social and violent behavior among pre-school children and the best methods for modifying such behavior.
This technology relates to a mathematical model of a biological process having a complex spatial geometry. The methods of this invention can be employed to model many biological processes, such as cell signaling in general and vision in particular. These models can also be used to model the pathology underlying diseases characterized by disrupted signaling pathways, and to identify target proteins at an appropriate site in a signal transduction network such that modulation of the target proteins elicits therapeutic effects. Methods of modeling diffusion processes, as well as machine-readable products embodying the methods are also disclosed. Issued US Patent 7113898.
This technology utilizes a set of mathematical algorithms that permit fast and robust reconstruction of signals from digital samples without the need to resort to band limitations or uniform sampling. This allows a signal to be digitized in a more sophisticated way, sampling it at frequent intervals when it is rapidly changing, and less often when it is changing slowly. Band limits imposed by uniform sampling are eliminated.
Procoder for Digital Video (ProcoderDV) was developed at the John F. Kennedy Center at Vanderbilt University to facilitate the collection of different forms of observational data from digital media files. Media files can be any files that contain events of interest on digital video or audio files. Data files can be of two general types: event files or transcription files. Files can be exported into MOOSES (Tapp & Wehby, 1995) format or SALT (Miller & Chapman, 1993) format or can be read directly by many popular statistical or spreadsheet programs. A code file can be used in conjunction with ProcoderDV to guide the coder inmarking events for later quantification and analysis.
The FACT toolsuite assists engineers working with complex aerospace systems to design and implement control systems that can maintain control even when the controlled system "fails." The tool suite uses a model-based approach where the designer creates design models of the plant and its associated control system, and the tools automatically generate code that implements fault-detection, isolation and control reconfiguration functions.
Interval Manager (INTMAN) is a computer-assisted alternative to traditional paper and pencil methods for collecting fixed interval time sampled observational data. The INTMAN data collection software runs on Pocket PC hand held computers and includes a desktop application for Microsoft Windows that is used for data analysis. Standard analysis options include modified frequencies, percent of intervals, conditional probabilities, and Kappa agreement matrices and values.