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300 available technologies

A Method for Regulating Glucokinase by Reaction With Nitric Oxide

Vanderbilt researchers have discovered a novel mechanism through which the insulin regulating enzyme glucokinase is regulated. This discovery provides a powerful way to screen for activators of glucokinase, which may lead to therapies for diabetes.

Easy-to-Fabricate, Cost-Effective, and Stable Surface Enhanced Raman Scattering (SERS) substrates

Vanderbilt researchers have developed a Surface Enhanced Raman Scattering (SERS) substrate with demonstrated signal amplification over one order of magnitude greater than commercially available SERS substrates. Very significantly, the newly developed substrates utilize a simple inexpensive imprinting process on nanoporous gold and are thus amenable for high-volume production.

Diamond Triode Devices with a Diamond Microtip Emitter

This technology is a diamond triode for micro and power electronics. Diamond microtip field emitters are used in triode vacuum electronic devices, sensors and displays. Diamond triode devices having integral anode and grid structures are fabricated using a patented process. Ultra-sharp tips are formed on the emitters in the fabrication process in which diamond is deposited into mold cavities in a two-step deposition sequence. During deposition of the diamond, the carbon graphite content is carefully controlled to enhance emission performance. The tips or the emitters are treated by post-fabrication processes to further enhance performance.

Ultrasonic Sensor for Non-intrusive Local Temperature, Transient Temperature and Heat Flux Measurements

An apparatus for measuring the temperature and heat flux of materials through the use of an ultrasonic sensor has been developed at Vanderbilt University. The sensor uses acoustic measurement techniques to determine the heat flux and temperature of material surfaces otherwise inaccessible in particular during system operation in order to enhance monitoring capabilities and reduce unsafe or impaired function due to extreme temperatures.

Precision Pneumatic Robot for MRI-Guided Neurosurgery

At Vanderbilt University, a robotic steering mechanism for MRI-guided neurosurgical ablation has been developed. The small robot has submilimeter precision and is fully MRI compatible. It aims to replace current surgical practices with minimally invasive procedures in order to enhance the treatment of cancer and numerous neurological disorders such as epilepsy.

A peptide therapeutic for atherosclerosis that restores lipid and cholesterol homeostasis

Atherosclerosis is a serious health concern; leading to 1.5 million heart attacks in the US each year and 795,000 strokes. Vanderbilt researchers have developed a peptide therapeutic that reduces development of atherosclerosis by 63% in mice fed a Western diet. This peptide's unique mechanism attacks the problem at the level of gene expression, returning lipid synthesis to homeostatic control, while also reducing cholesterol and triglyceride levels and improving liver function.

cSN50.1 peptide protects islets and stops type 1 diabetes

Researchers at Vanderbilt have developed a peptide therapeutic that rendered non-obese diabetic (NOD) mice diabetes-free and insulin-independent for at least one year after only 2 days of treatment at the early stage of disease.

Cuffed Inner Cannula and Flexible Outer Cannula Tracheostomy Tube

This new tracheostomy tube design prevents the need for decannulation when changing from a cuffed to cuffless (or vice versa) tracheostomy. It also enables a comfortable and fit in patients with both large and small neck diameters. The tube enhances patient safety by maintaining the airway at all times when downsizing or upsizing.

Polar Liquid Crystals with High Dielectric Anisotropy

Vanderbilt inventors have developed a new class of liquid crystals with high dielectric anisotropy. A new class of liquid crystals containing boron in their structure has been developed with high dielectric anisotropy, which results in low threshold voltages.

Enhanced Cooling of Oil Based Transformers and Other Heat Generating Equipment with NanoParticle Suspensions

Nanometer-sized, low-cost, readily available, particulate nanodiamond is used as an additive to the mineral oil used in electrical power transformers and other oil-cooled electrical equipment to enhance the thermal conductivity [TC] and dielectric properties of the oil without compromising the oil's required electrical insulation, such that failures are suppressed, oil life is greatly extended and load boundaries are elevated. This could extend transformer life and allow increases to transformer MVA ratings.

Biohybrid, Photoelectrochemical Energy Conversion Device Based on Photosystem I Deposited Silicon Electrodes

Summary: Aresearch team at Vanderbilt University have developed a biohybrid, photoelectrochemical energy conversion device with multilayer films of Photosystem I (PSI) deposited on silicon electrodes, which yielded an average photocurrent density of 875 µA/cm2; one of the highest reported photocurrent densities for a film of PSI deposited onto an electrode of any material.

On Chip Polarimetry for HTS

Using microfluidic technology developed by the Bornhop Lab at Vanderbilt, this invention enables the rapid determination of the optical activity of compounds and solutions. Due to the nature of this invention, it is possible to screen a multitude of samples in a high throughput manner in less time with less material and greater accuracy than the industry standards.

Inhibition of Hyperacute Rejection in Pulmonary Xenograft

One of the several problems with organ transplantation is the actual procurement of needed organs. The number of patients requiring transplants far exceeds the number of available organs. Thus, tissues and organs from different species (xenografts) may offer help to many more potential organ donors, and consequently may help the organ shortage. However, many obstacles still remain with xenografts, with the major challenge being tissue/organ rejection. The need to reduce this rejection and the injury it can inflict upon the transplanted tissue/organ therefore remains high. Vanderbilt researchers have patented a technology that helps to prevent the rejection of transplanted tissues/organs and the injury that occurs to these tissues. This technology inhibits specific pathways that regulate platelet adhesion and aggregation, which have been linked to the rejection of transplanted tissues/organs.

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