Available Technologies

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292 available technologies

NanoBioReactor for Monitoring Small Cell Populations

NanoBioreactors recreate the microenvironments of normal tissue, non-adherent cells, tumor-infected tissue and wounded tissue in vitro. These microfabricated bioreactors provide independent control of chemokine and growth factor gradients, shear forces, cellular perfusion and the permeability of physical barriers to cellular migration. This fine control allows detailed optical and electrochemical observations of normal, immune and cancerous cells during activation, division, cell migration, intravasation, extravasation and angiogenesis.

High Bandwidth, Hot Gas and Liquid, Rotary Proportional Valves

Inventors at Vanderbilt University have developed a high performance rotary servo valve to be used with hot/cold liquids and gases. This valve can be directly actuated by a rotary servo motor, eliminating the need for linear actuating devices. It exhibits a compact design that allows for increased control, precision, and efficiency.

Gratings on Porous Silicon Structures for Sensing Applications

In this technology diffraction-based sensors made from porous materials are used for the detection of small molecules. The porous nature of the diffraction gratings that gives rise to an extremely large active sensing area enables a very high level of sensitivity. Specificity is achieved by functionalizing the porous gratings with selective binding species.

Direct Imprinting of Porous Substrates

This easily adoptable technology consists of an inexpensive and reproducible method to imprint micron and sub-micron features into porous materials by pressing a reusable stamp directly into the porous material. This method of direct imprinting (DIP™) has the potential to enable an entirely new class of low-cost porous nanomaterial based devices.

Free Standing Nanocrystal Thin Films

Vanderbilt researchers have developed a process that creates free standing nanocrystalline thin films using a simple, robust and cost- efficient process. This paves the way for manufacturing conformal films of nanocrystals at a fraction of the cost as compared to techniques currently used. The process could be applied in the manufacture of a number of end products such as solar cells supercapacitors, magnetic storage, semiconductor devices and catalysis.

Synthetic Beam Chopper

A new system of signal modulation and lock-in amplification has been developed at Vanderbilt University. The invention serves as a low cost alternative to current mechanical beam choppers and lock-in amplifiers, with lower limits of detection, decreased need for mechanical precision, and improved accuracy.

Novel Target Regulating Angiogenesis

Vanderbilt scientists have discovered that the receptor tyrosine phosphatase DEP-1 plays a significant role in angiogenesis and that modulation of the DEP-1 receptor with certain agents can affect endothelial cell growth. The research team has developed antibodies that bind to the ectodomain of a mammalian transmembrane protein known as DEP-1 (for density enhanced protein) or CD148. CD148 (also named DEP-1/PTPn) is a receptor-like protein tyrosine phosphatase that is abundantly expressed in vascular endothelial cells, hematopoietic-cell lineages, duct epithelia of thyroid, mammary and gastrointestinal tissues.

A Method for Regulating Glucokinase by Reaction With Nitric Oxide

Vanderbilt researchers have discovered a novel mechanism through which the insulin regulating enzyme glucokinase is regulated. This discovery provides a powerful way to screen for activators of glucokinase, which may lead to therapies for diabetes.

Easy-to-Fabricate, Cost-Effective, and Stable Surface Enhanced Raman Scattering (SERS) substrates

Vanderbilt researchers have developed a Surface Enhanced Raman Scattering (SERS) substrate with demonstrated signal amplification over one order of magnitude greater than commercially available SERS substrates. Very significantly, the newly developed substrates utilize a simple inexpensive imprinting process on nanoporous gold and are thus amenable for high-volume production.

cSN50.1 peptide protects islets and stops type 1 diabetes

Researchers at Vanderbilt have developed a peptide therapeutic that rendered non-obese diabetic (NOD) mice diabetes-free and insulin-independent for at least one year after only 2 days of treatment at the early stage of disease.

Cuffed Inner Cannula and Flexible Outer Cannula Tracheostomy Tube

This new tracheostomy tube design prevents the need for decannulation when changing from a cuffed to cuffless (or vice versa) tracheostomy. It also enables a comfortable and fit in patients with both large and small neck diameters. The tube enhances patient safety by maintaining the airway at all times when downsizing or upsizing.

Polar Liquid Crystals with High Dielectric Anisotropy

Vanderbilt inventors have developed a new class of liquid crystals with high dielectric anisotropy. A new class of liquid crystals containing boron in their structure has been developed with high dielectric anisotropy, which results in low threshold voltages.

Enhanced Cooling of Oil Based Transformers and Other Heat Generating Equipment with NanoParticle Suspensions

Nanometer-sized, low-cost, readily available, particulate nanodiamond is used as an additive to the mineral oil used in electrical power transformers and other oil-cooled electrical equipment to enhance the thermal conductivity [TC] and dielectric properties of the oil without compromising the oil's required electrical insulation, such that failures are suppressed, oil life is greatly extended and load boundaries are elevated. This could extend transformer life and allow increases to transformer MVA ratings.

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