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Medical Imaging

29 available technologies

Hyper-SHIELDED - Preserving Parahydrogen Spin Order by Efficient Transfer of Nuclear Singlet

Hyperpolarization of nuclear spin ensembles has increased NMR sensitivity to a level that is now enabling detection of metabolism in biological tissue on a time-scale of seconds. The present invention is a pulse sequence that efficiently transforms parahydrogen spin order into heteronuclear magnetization. This was achieved via a single streamlined sequence without recursive application, by finding sequential analytic solutions to the density matrix evolution for each of four independent intervals that collectively flank two proton inversions and one heteronuclear excitation. The name hyper-SHIELDED (Singlet to Heteronuclei by Interative Evolution Locks Dramatic Enhancement for Delivery) reflects the sequence's protective effect on PHIP hyperpolarization.

Two Dimensional Ultra Short Echo Time MRI via Slice Saturation

Novel saturation-based method for creating a 2D MR image of a slice of interest from an object is described. This method does not use gradients during excitation, which allows for the minimum echo time and greatly reduces sensitivity to gradient imperfections. Two signals are acquired -- one from the entire sample without spatial selection; the second from the entire sample following a slice saturation preparation. The difference between the two signals results in the signal only from the saturated 2D slice. The sequence has been implemented on both human (Philips) and animal (Agilent) scanners.

Molecular Image Fusion: Cross-Modality Modeling and Prediction Software for Molecular Imaging

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