Fluorescent labels having near-infrared (NIR) emission wavelengths have the ability to penetrate tissue deeper than other emission wavelengths, providing enormous potential for non-invasive imaging applications. However, advancement of optical imaging (particularly NIR imaging) is hindered by the limitation of narrow Stokes shift of most infrared dyes currently available in the market. Vanderbilt researchers have developed a novel NIR dye (4-Sulfonir) for multichannel imaging that enables in vivo imaging of multiple targets due to its large Stokes shift. 4-Sulfonir with its unique large Stokes shift (~150 nm) and wide excitation spectrum could be used in parallel with other NIR dyes for imaging two molecular events simultaneously in one target.
This technology eliminates the need to place cortical fiducial markers during image guided neurosurgery. As an additional and important feature, the technology is able to compensate for brain shift due to deformation of the brain during surgery.
Vanderbilt researchers have developed a device that allows for a more accurate and precise detection of brain tumor borders in real time. This allows neurosurgeons to remove all tumor tissue without removing critical normal tissue in surgical brain resections.
Vanderbilt researchers have developed a novel single-voxel localization technique for Magnetic Resonance Spectroscopy (MRS), termed ASSESS (Arbitrary Shape Selective Excitation Summed Spectroscopy). ASSESS can measure spectra from regions of arbitrary shape allowing the user to customize the region of interest.
Vanderbilt inventors have developed and tested a device (C-in) and method that would shift the current invasive, risky surgical procedure of cochlear implantation to a less invasive outpatient procedure.
Vanderbilt presents an intraoperative device for taking the guesswork out of whether or not a threaded component is securely affixed to bone. This device is an anchor driver that automatically releases upon proper seating of the anchor on the bone of interest.
PK11195 is a high-affinity ligand of the peripheral benzodiazepine receptor (PBR). By linking lanthanide chelates to the PK11195 targeting moiety, Vanderbilt researchers have generated a range of PBR-targeted imaging probes capable of visualizing a number of disease states at cellular levels using a variety of imaging modalities (fl uorescence, PET and SPECT, MRI, electron microscopy).
An apparatus for evaluating a target of interest of a living subject. In one embodiment, the apparatus has a first light source for generating a broadband light, a second light source for generating a monochromatic light, a beamsplitter optically coupled to the first light source for receiving the broadband light and splitting it into a reference light and a sample light, a reference arm optically coupled to the beamsplitter for receiving the reference light and returning it into the beamsplitter, and a probe having a working end placed proximal to a target of interest of a living subject, optically coupled to the beamsplitter and the second light source for receiving the sample light and the monochromatic light, delivering them from the working end to the target of interest, collecting from the working end a backscattering light and a Raman scattering light that are obtained from interaction of the sample light and the monochromatic light with the target of interest, respectively, and returning the backscattering light into the beamsplitter so as to generate an interference signal between the returned backscattering light and the returned reference light in the beamsplitter.
A flexible endoscope for ophthalmic orbital surgery is presented. The endoscope has illuminating fiber, image fiber and a free conduit to deliver purge gas/fluid in addition to instruments such as ablation instruments, coagulating instrument or a medication delivery instrument.
This technology is fundamentally a new way to align a patient in an image-guided surgery system (registration) without the use of fiducial markers on the cranium exterior. The system utilizes laser range scanning technology, the natural features on the cortical surface, and the corresponding natural features derived from the patient's preoperative magnetic resonance tomograms. In addition, the technology is amenable to measuring deformation (brain shift) for use within a mathematical model-based strategy for shift compensation.
Elastography is the direct imaging of tissue elasticity parameters. The invention is a method of modeling of tissue called Modality Independent Elastography (MIE), within the context of dermoscopy imaging, for the purpose of optimizing the similarity between model-created images and the patient acquired images.
This technology relates to a device and method for non-invasive evaluation of a target of interest of a living subject, and in particular to devices and methods that integrate confocal imaging with confocal Raman spectroscopy, for non-invasive evaluation of the biochemical compositions and morphological details of normal and cancerous skin lesions of a living subject.